INT9372

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 86
Total Number 88
Disease Relevance 46.54
Pain Relevance 41.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lbp) transport (Lbp) extracellular space (Lbp)
extracellular region (Lbp)
Anatomy Link Frequency
sciatic nerve 2
spine 2
spinal 1
shoulder 1
hip 1
Lbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 2051 100.00 Very High Very High Very High
shoulder pain 4 99.70 Very High Very High Very High
Pain 440 99.58 Very High Very High Very High
Sciatic nerve 12 99.46 Very High Very High Very High
unmyelinated 3 99.42 Very High Very High Very High
Analgesic 18 97.92 Very High Very High Very High
qutenza 9 97.36 Very High Very High Very High
cINOD 16 96.96 Very High Very High Very High
imagery 37 94.08 High High
Lasting pain 48 93.76 High High
Disease Link Frequency Relevance Heat
Low Back Pain 2114 100.00 Very High Very High Very High
Nicotine Addiction 84 99.90 Very High Very High Very High
Shoulder Pain 4 99.70 Very High Very High Very High
Pain 464 99.46 Very High Very High Very High
Fatigue 12 99.24 Very High Very High Very High
Injury 28 99.08 Very High Very High Very High
Obesity 4 96.96 Very High Very High Very High
Recurrence 25 96.92 Very High Very High Very High
Back Injuries 7 92.84 High High
Osteoporosis 7 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The types of PA to attain the effects mentioned above are known except in the case of prevention of LBP, but dose-response relationships are poorly known; at best, semiquantitatively on the basis of just a few studies.
Negative_regulation (prevention) of LBP
1) Confidence 0.58 Published 2001 Journal Med Sci Sports Exerc Section Body Doc Link 11427782 Disease Relevance 0.10 Pain Relevance 0
The main route to prevention of LBP among nurses is likely to lie in improved ergonomics and psychological health in their work place.
Negative_regulation (prevention) of LBP
2) Confidence 0.58 Published 2001 Journal J Adv Nurs Section Body Doc Link 11903709 Disease Relevance 0 Pain Relevance 0
SUMMARY OF BACKGROUND DATA: Improving the control of lumbar NZ and enhancing muscle activation patterns ensuring spinal stability have been proposed as means for secondary prevention of LBP and disability.
Negative_regulation (prevention) of LBP in spinal
3) Confidence 0.51 Published 2006 Journal Spine Section Body Doc Link 16915076 Disease Relevance 0 Pain Relevance 0
This is the first randomized trial to show positive influence on LBP beliefs in a primary prevention setting, and these findings have potentially important public health implications for prevention of LBP.
Negative_regulation (prevention) of LBP associated with backache
4) Confidence 0.51 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19418075 Disease Relevance 0.37 Pain Relevance 0.37
An improvement of these conditions must be taken into account in order to prevent LBP.
Negative_regulation (prevent) of LBP associated with backache
5) Confidence 0.51 Published 2004 Journal Folia Med (Plovdiv) Section Abstract Doc Link 15819458 Disease Relevance 0.78 Pain Relevance 0.78
This article suggests reasons for the difficulty in understanding and preventing low-back pain (LBP), provides a framework for understanding the causes of reported LBP, and highlights an important new direction in research that could accelerate progress in reducing LBP.
Negative_regulation (reducing) of LBP associated with backache
6) Confidence 0.51 Published 2002 Journal AIHA J (Fairfax, Va) Section Abstract Doc Link 11843428 Disease Relevance 0.97 Pain Relevance 0.77
Regular participation in aerobics correlated with a reduced lifetime risk for LBP.
Negative_regulation (reduced) of LBP associated with backache
7) Confidence 0.51 Published 2002 Journal J South Orthop Assoc Section Abstract Doc Link 12539937 Disease Relevance 0.84 Pain Relevance 0.74
Physical and mental readiness to cope with changes in voluntary motions is a prerequisite for the prevention of LBP in daily work, which constitutes time-sequential changes in posture and motion under various environmental conditions.
Negative_regulation (prevention) of LBP associated with backache
8) Confidence 0.51 Published 1997 Journal Ind Health Section Abstract Doc Link 9127549 Disease Relevance 0.71 Pain Relevance 0.71
This study provides evidence that attribution theory is useful in the study of LBP, including in future interventions in the prevention of LBP.
Negative_regulation (prevention) of LBP associated with backache
9) Confidence 0.50 Published 2002 Journal Appl Occup Environ Hyg Section Abstract Doc Link 12419103 Disease Relevance 0.86 Pain Relevance 0.79
Job modification is often effective for prevention of LBP, but employee selection is generally risky, unreliable, and (increasingly) illegal.
Negative_regulation (prevention) of LBP
10) Confidence 0.50 Published 1992 Journal Occup Med Section Abstract Doc Link 1411853 Disease Relevance 0.07 Pain Relevance 0.07
CONCLUSION: Improvement of sagittal deviation of apical lumbar vertebra, instrumentation of third or fourth vertebrae, male gender, and fusion success were correlated with postoperative improvement of LBP after posterior decompression and pedicle screw fixation for symptomatic degenerative lumbar spine disease.This research suggests that the methods directed at the improvement in sagittal spinal balance of the lumbar spine, careful selection of fusion levels, and improvement of fusion rate might be beneficial for decreasing LBP after surgery in degenerative lumbar spine disease.


Negative_regulation (decreasing) of LBP in spine
11) Confidence 0.50 Published 2010 Journal Spine Section Body Doc Link 20354466 Disease Relevance 0 Pain Relevance 0
Following sciatic nerve constriction, the 110/140 LBP-I was downregulated in the ipsilateral L4-5 DRG.
Negative_regulation (downregulated) of LBP in sciatic nerve associated with sciatic nerve
12) Confidence 0.49 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8350386 Disease Relevance 0.07 Pain Relevance 0.40
To prevent LBP, it may be worth considering adjusting the working height of equipment in kitchens used for school lunch services to suit the male and female cooks.
Negative_regulation (prevent) of LBP associated with backache
13) Confidence 0.48 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1971070 Disease Relevance 0.57 Pain Relevance 0.57
These findings indicate the need to improve conditions of materials handling to help prevent LBP among cooks.
Negative_regulation (prevent) of LBP associated with backache
14) Confidence 0.48 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1971070 Disease Relevance 0.56 Pain Relevance 0.56
The ergonomic organization of the workplace should represent a major element of future strategies to prevent LBP.
Negative_regulation (prevent) of LBP associated with backache
15) Confidence 0.45 Published 1994 Journal Eur Spine J Section Abstract Doc Link 7874536 Disease Relevance 0.90 Pain Relevance 0.90
These preliminary results support that a relationship may exist between flexed spinal postures, reduced back muscle endurance, physical inactivity and LBP in subjects with a history of flexion injury and pain.
Negative_regulation (reduced) of LBP in back muscle associated with pain, injury and backache
16) Confidence 0.43 Published 2006 Journal Man Ther Section Abstract Doc Link 15953751 Disease Relevance 0.85 Pain Relevance 0.75
The resulting relief of LBP is confirmed by drivers who used this type of seat.


Negative_regulation (relief) of LBP
17) Confidence 0.43 Published 2001 Journal J Manipulative Physiol Ther Section Body Doc Link 11753332 Disease Relevance 0.06 Pain Relevance 0
The aim of this study was to examine the persistence of LBP among a cohort of industrial employees studied in four successive surveys during a total of 28 years.
Spec (examine) Negative_regulation (persistence) of LBP associated with backache
18) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16360271 Disease Relevance 0.86 Pain Relevance 0.86
Naturally, strategies aiming at effectively preventing or treating LBP are urgently needed [14].
Negative_regulation (preventing) of LBP associated with backache
19) Confidence 0.43 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2831827 Disease Relevance 1.14 Pain Relevance 0.97
Low back support had no effect on low back and neck-shoulder subjective fatigue and neck-shoulder pain but tended to limit the LBP increase during driving.
Negative_regulation (limit) of LBP in shoulder associated with fatigue, shoulder pain and backache
20) Confidence 0.42 Published 2005 Journal Pathophysiology Section Abstract Doc Link 16223576 Disease Relevance 1.55 Pain Relevance 1.32

General Comments

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