INT93728

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.11
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
T cells 4
lymphocyte 1
cytotoxic T lymphocytes 1
Cd28 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 99 98.60 Very High Very High Very High
cytokine 26 83.48 Quite High
Inflammation 34 83.08 Quite High
Central nervous system 1 58.36 Quite High
Angina 16 50.00 Quite Low
antagonist 11 30.00 Quite Low
headache 1 25.00 Low Low
Leflunomide 3 7.84 Low Low
methotrexate 3 6.72 Low Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 261 99.36 Very High Very High Very High
Alagille Syndrome 96 99.20 Very High Very High Very High
Rheumatoid Arthritis 99 98.60 Very High Very High Very High
Infection 68 94.04 High High
Chronic Fatigue Syndrome 11 93.44 High High
Communicable Diseases 19 91.80 High High
Herpes Simplex Virus 6 89.84 High High
Fatigue 3 85.68 High High
Rheumatic Diseases 9 83.28 Quite High
INFLAMMATION 45 83.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, CD28 expression was assessed and expressed as mean fluorescence intensity (geometric mean of the CD28 fluorescence value on all CD4+ T cells).
Gene_expression (expression) of CD28 in T cells
1) Confidence 0.35 Published 2006 Journal Circulation Section Body Doc Link 16682617 Disease Relevance 0.16 Pain Relevance 0
Analysis of CD28 mean fluorescence intensity showed that the expression of CD28 on cell surface significantly increased after incubation with increasing doses of infliximab (P for trend=0.03).
Gene_expression (expression) of CD28
2) Confidence 0.35 Published 2006 Journal Circulation Section Body Doc Link 16682617 Disease Relevance 0.13 Pain Relevance 0
In addition, CD28 expression was assessed and expressed as mean fluorescence intensity (geometric mean of the CD28 fluorescence value on all CD4+ T cells).
Gene_expression (value) of CD28 in T cells
3) Confidence 0.31 Published 2006 Journal Circulation Section Body Doc Link 16682617 Disease Relevance 0.15 Pain Relevance 0
In addition, CD28 expression was assessed and expressed as mean fluorescence intensity (geometric mean of the CD28 fluorescence value on all CD4+ T cells).
Gene_expression (expressed) of CD28 in T cells
4) Confidence 0.28 Published 2006 Journal Circulation Section Body Doc Link 16682617 Disease Relevance 0.16 Pain Relevance 0
There were also more cells expressing CD28, SLe(x), CD4, HLA-DR, and NU-B2 in H. pylori-positive ulcer patients than in non-ulcer patients and healthy volunteers.
Gene_expression (expressing) of CD28
5) Confidence 0.20 Published 2001 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 11204803 Disease Relevance 0.15 Pain Relevance 0
The high proportion of CMV-specific CD4pos T cells in the CD28neg population was reported earlier [17,26], but had not been studied in RA.
Gene_expression (population) of CD28neg in T cells associated with rheumatoid arthritis and cytomegalovirus infection
6) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945035 Disease Relevance 1.08 Pain Relevance 0.18
-secreting cells within the CD28neg CD4pos population in response to CMV Ags
Gene_expression (population) of CD28neg associated with alagille syndrome and cytomegalovirus infection
7) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945035 Disease Relevance 1.85 Pain Relevance 0.05
CD28 expression was evaluated.


Gene_expression (expression) of CD28
8) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945035 Disease Relevance 1.98 Pain Relevance 0.21
An increased number of CD8+ cytotoxic T lymphocytes and CD38 and HLA-DR activation markers have been reported, and a decrease in CD11b expression associated with an increased expression of CD28+ T subsets has been observed.
Gene_expression (expression) of CD28 in cytotoxic T lymphocytes
9) Confidence 0.11 Published 2009 Journal Autoimmun Rev Section Abstract Doc Link 18801465 Disease Relevance 0.77 Pain Relevance 0.15
However, the decrease of lymphocyte number was less marked than the large decrease of transcript levels of CD28, CD69 and LCK.
Gene_expression (levels) of CD28 in lymphocyte
10) Confidence 0.08 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.68 Pain Relevance 0

General Comments

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