INT93734

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 76
Total Number 76
Disease Relevance 61.95
Pain Relevance 18.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
cerebral cortex 6
margin 4
spinal cord 4
endothelial cells 4
photoreceptors 4
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 26 100.00 Very High Very High Very High
rheumatoid arthritis 17 100.00 Very High Very High Very High
Morphine 37 99.98 Very High Very High Very High
tricyclic antidepressant 2 99.96 Very High Very High Very High
Glutamate 11 99.84 Very High Very High Very High
dexamethasone 43 99.76 Very High Very High Very High
ischemia 399 99.74 Very High Very High Very High
Hippocampus 52 99.68 Very High Very High Very High
Sciatic nerve 11 99.68 Very High Very High Very High
fluoxetine 39 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1339 100.00 Very High Very High Very High
Cancer 90 100.00 Very High Very High Very High
Rheumatoid Arthritis 18 100.00 Very High Very High Very High
Lymphatic System Cancer 14 100.00 Very High Very High Very High
Stress 214 99.98 Very High Very High Very High
Hepatotoxicity 31 99.98 Very High Very High Very High
Herpes Simplex Virus 2 99.98 Very High Very High Very High
Convulsion 19 99.96 Very High Very High Very High
Cv Unclassified Under Development 317 99.74 Very High Very High Very High
Ulcers 11 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that 20 microM FL treatment can significantly increase the proliferation rate of NSCs (p<0.05), and up-regulate the mRNA and protein expressions of Bcl-2 in Day-7 FL-treated NSCs (p<0.01).
Positive_regulation (up-regulate) of Gene_expression (expressions) of Bcl-2 in NSCs associated with fluoxetine
1) Confidence 0.70 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.40 Pain Relevance 0.95
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Positive_regulation (increases) of Gene_expression (expression) of bcl-2 associated with ischemia
2) Confidence 0.69 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.61 Pain Relevance 0.15
These findings suggest that morphine exposure during the first embryonic days may enhance the susceptibility of neuroblasts to apoptosis by upregulating the ratio of Bax to Bcl-2 protein expression and increasing downstream caspase-3 activity.
Positive_regulation (upregulating) of Gene_expression (expression) of Bcl-2 protein in neuroblasts associated with apoptosis and morphine
3) Confidence 0.69 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.15 Pain Relevance 0.69
Mechanism(s) implicated in at least some types of preconditioning include increased Bcl2 and Cyp2C11 expression (Koerner and Alkayed 2007).
Positive_regulation (increased) of Gene_expression (expression) of Bcl2
4) Confidence 0.68 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.57 Pain Relevance 0.06
We observed increased Bcl2 expression in males at the protective developmental A1254 exposure (1.0 mg/kg/day), but it was also increased at the nonprotective developmental A1254 exposure (0.1 mg/kg/day), suggesting that Bcl2 up-regulation alone does not mediate the neuroprotective effects of developmental PCB exposure.
Positive_regulation (increased) of Gene_expression (expression) of Bcl2
5) Confidence 0.68 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.49 Pain Relevance 0.03
Developmental PCB exposure modulates systemic (Meerts et al. 2004) and brain (Colciago et al. 2006) levels of estrogen, increases Bcl2 expression in adult testes (Hsu et al. 2007), and increases expression and activity of hepatic Cyp2C11 (Chen et al. 1992; Kramer et al. 1999).
Positive_regulation (increases) of Gene_expression (expression) of Bcl2 in brain
6) Confidence 0.68 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 1.10 Pain Relevance 0.16
Group 1 had increased bcl-2 and bax protein expression in hippocampal CA1 region at 6 h after CPB (bcl-2, 0.18 +/- 0.05 versus 0.09 +/- 0.01; P = 0.02; bax, 0.20 +/- 0.06 versus 0.04 +/- 0.02; P = 0.01; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of Gene_expression (expression) of bcl-2
7) Confidence 0.66 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.29 Pain Relevance 0.21
In contrast, chronic administration of clinically effective antidepressants from four different classes, ie fluoxetine, reboxetine, tranylcypromine, and electroconvulsive seizures (ECS) upregulated Bcl-2 mRNA expression in the Cg, Fr, and CeA.
Positive_regulation (upregulated) of Gene_expression (expression) of Bcl-2 mRNA in CeA associated with antidepressant, convulsion, amygdala and fluoxetine
8) Confidence 0.62 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 1.05 Pain Relevance 0.63
Furukawa et al. (23) showed that cycloheximide treatment at low levels insufficient to fully inhibit protein synthesis enhances Bcl-2 expression.
Positive_regulation (enhances) of Gene_expression (expression) of Bcl-2
9) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729957 Disease Relevance 1.36 Pain Relevance 0.03
Overall, given the prevalence of Bcl-2 overexpression in diverse cancers, nonclinical findings suggest that oblimersen may function in tumors from a broad range of genetic backgrounds.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with cancer
10) Confidence 0.56 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.99 Pain Relevance 0
HBO-PC enhanced activities of Mn-superoxide dismutase (Mn-SOD) and catalase, as well as the expression of Bcl-2 in the mitochondria in the normal spinal cord at 24 h after the last pretreatment (before spinal cord ischemia), and retained higher levels throughout the early reperfusion in the ischemic spinal cord.
Positive_regulation (after) of Gene_expression (expression) of Bcl-2 in spinal cord associated with ischemia and spinal cord
11) Confidence 0.50 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19196076 Disease Relevance 0.82 Pain Relevance 0.71
Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion.
Positive_regulation (vector-mediated) of Gene_expression (expression) of Bcl-2 in motor neurons associated with sciatica
12) Confidence 0.50 Published 2001 Journal Exp. Neurol. Section Title Doc Link 11259110 Disease Relevance 0.92 Pain Relevance 0.45
Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos.
Positive_regulation (increases) of Gene_expression (ratio) of Bcl-2 in embryos associated with morphine
13) Confidence 0.50 Published 2010 Journal J. Mol. Neurosci. Section Title Doc Link 19936637 Disease Relevance 0.17 Pain Relevance 0.52
Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3.
Positive_regulation (activation) of Gene_expression (expression) of Bcl2
14) Confidence 0.50 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.20 Pain Relevance 0.67
Group 1 had increased bcl-2 and bax protein expression in hippocampal CA1 region at 6 h after CPB (bcl-2, 0.18 +/- 0.05 versus 0.09 +/- 0.01; P = 0.02; bax, 0.20 +/- 0.06 versus 0.04 +/- 0.02; P = 0.01; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of Gene_expression (expression) of bcl-2
15) Confidence 0.47 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.29 Pain Relevance 0.21
Reboxetine, tranylcypromine, and ECS selectively increased Bcl-xl, but not Bcl-2 mRNA expression in the hippocampus.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Bcl-2 mRNA in hippocampus associated with convulsion and hippocampus
16) Confidence 0.45 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 1.04 Pain Relevance 0.67
Chemical ADT but not ECS, robustly enhanced Bcl-2 expression in the medial amygdaloid nucleus and ventromedial hypothalamus.
Positive_regulation (enhanced) of Gene_expression (expression) of Bcl-2 in nucleus associated with convulsion
17) Confidence 0.45 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 1.01 Pain Relevance 0.67
Recent studies indicate that overexpression of Bcl-2 gene could reduce heaptocellular apoptosis after reperfusion and protect against hepatic I/R injury.[17] Bcl-2 homodimers inhibit cell death.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with injury, apoptosis and death
18) Confidence 0.45 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 1.44 Pain Relevance 0.07
Therefore, increase in the expression of Bcl-2 may determine survival following apoptotic stimuli and attenuate the antiapoptotic effect of Bcl-2 gene by reducing postischemic apoptosis.[16] However, attempts to protect against hepatic I/R injury by alleviating the possible detrimental effects of portal venous congestion have not achieved satisfactory results.
Positive_regulation (increase) of Gene_expression (expression) of Bcl-2 associated with hyperemia, injury and apoptosis
19) Confidence 0.45 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 1.39 Pain Relevance 0.04
These data are consistent with a previous study finding that overexpression of Bcl-2 reduced ischemia/reperfusion injury.[16] In addition, this study provides a new insight into the mechanism by which L-arginine mediates hepatoprotective.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with reperfusion injury and ischemia
20) Confidence 0.45 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 1.42 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox