INT93738

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Context Info
Confidence 0.74
First Reported 2000
Last Reported 2010
Negated 4
Speculated 5
Reported most in Body
Documents 63
Total Number 71
Disease Relevance 57.66
Pain Relevance 23.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf1a) extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a)
plasma membrane (Tnfrsf1a) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)
Anatomy Link Frequency
neurons 13
blood 3
WBC 3
macrophages 2
plasma 2
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 644 100.00 Very High Very High Very High
cytokine 454 100.00 Very High Very High Very High
Sciatic nerve 18 99.72 Very High Very High Very High
Root ganglion neuron 13 99.56 Very High Very High Very High
qutenza 783 99.36 Very High Very High Very High
Hippocampus 93 99.28 Very High Very High Very High
Inflammation 989 99.24 Very High Very High Very High
agonist 166 99.22 Very High Very High Very High
ischemia 149 98.90 Very High Very High Very High
Neuropathic pain 8 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 727 100.00 Very High Very High Very High
Targeted Disruption 389 100.00 Very High Very High Very High
Cancer 226 100.00 Very High Very High Very High
Necrosis 147 100.00 Very High Very High Very High
Adhesions 27 100.00 Very High Very High Very High
Cytomegalovirus Infection 9 99.96 Very High Very High Very High
Nociception 103 99.92 Very High Very High Very High
Neurodegenerative Disease 127 99.80 Very High Very High Very High
Apoptosis 556 99.60 Very High Very High Very High
Nervous System Injury 48 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since TRAPS is an autosomal dominant disease, with patients generally carrying one wild-type allele and one mutant allele, it was important to test the effects of coexpression of mutant and wild-type TNFR1.
Gene_expression (coexpression) of TNFR1 associated with tumor necrosis factor receptor-associated periodic syndrome and disease
1) Confidence 0.74 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.92 Pain Relevance 0.04
receptors, TNFR1 and TNFR2, are expressed in peripheral nerves [16].
Gene_expression (expressed) of TNFR1 in peripheral nerves
2) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.86 Pain Relevance 0.80
In rat inflammation or nerve injury models, increases in TNFR1 expression are reported by several other researchers [15,17,28-30].
Gene_expression (expression) of TNFR1 in nerve associated with nervous system injury and inflammation
3) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.00 Pain Relevance 0.58
TNFR1 is expressed in dorsal root ganglion neurons and plays a potential role in nociception [13].
Gene_expression (expressed) of TNFR1 in neurons associated with nociception, ganglion cysts and root ganglion neuron
4) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.90 Pain Relevance 0.80
is released, and TNFR1 expression in neurons is increasing in proportion to the changes in TNF-?
Gene_expression (expression) of TNFR1 in neurons
5) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.17 Pain Relevance 0.80
This defect was also observed in cells from TNFR1 'knock-in' mice expressing the T50M mutation [56].
Gene_expression (expressing) of TNFR1 associated with targeted disruption
6) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.87 Pain Relevance 0.04
In the capsaicin treated group, TNFR1 was identified in 52.89 ± 2.89% of neurons with TRPV1 immunoreactivity (P < 0.05 compared with the untreated group), and TNFR1 was found in 73.63 ± 3.54% of TRPV1 neurons in the resiniferatoxin treated group (P < 0.01 compared with the untreated group; P < 0.05 compared with the capsaicin treated group).
Gene_expression (found) of TNFR1 in neurons associated with qutenza
7) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.26 Pain Relevance 0.83
Significantly decreased TNFR1 staining was also found in DRG neurons of the PBN plus resiniferatoxin treated group (11.08 ± 1.39%, n = 534, P < 0.01) compared that with resiniferatoxin treated group (16.5 ± 1.37%) (Fig. 3B).


Gene_expression (staining) of TNFR1 in neurons associated with dorsal root ganglion
8) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.62 Pain Relevance 1.10
The TNFR1 staining increase after capsaicin (1 ?
Gene_expression (staining) of TNFR1 associated with qutenza
9) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.48 Pain Relevance 1.06
Staining for TRPV1 and TNFR1 were both observed primarily in small size neurons.
Gene_expression (Staining) of TNFR1 in neurons
10) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.62 Pain Relevance 0.83
In present experiment, TNFR1 is positively immunostained in 10% of mouse DRG neurons and almost all of which were small size neurons which suggests a potential role of TNFR1 in transmission of nociception.
Gene_expression (immunostained) of TNFR1 in neurons associated with nociception and dorsal root ganglion
11) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.98 Pain Relevance 0.75
Dual staining for TRPV1 and TNFR1 was observed in 41.04 ± 3.94% of TRPV1 immunostaining positive neurons (Table 1, Fig. 1 Merge) (n = 592).
Gene_expression (staining) of TNFR1 in neurons
12) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.67 Pain Relevance 0.78
Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilateral crush or chronic constriction injury (CCI) of mouse sciatic nerves using enzyme-linked immunoassay.
Spec (investigated) Gene_expression (levels) of TNFR1 in sciatic nerves associated with eae, injury and sciatic nerve
13) Confidence 0.59 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.10 Pain Relevance 0.48
In these transgenic mice, TNFR1 deletion reduces Aß pathology, microglia activation, BACE1 activity, neuron loss, and memory deficits compared to transgenic APP23 mice expressing normal levels of TNFR1 [176].
Gene_expression (expressing) of TNFR1 in neuron associated with targeted disruption
14) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.20 Pain Relevance 0.22
TNFR1 is expressed in most cell types, and can be activated by binding of either solTNF or tmTNF, with a preference for solTNF; whereas TNFR2 is expressed primarily by cells of the immune system (including microglia) and by endothelial cells, and is preferentially activated by tmTNF [15,16].


Gene_expression (expressed) of TNFR1 in microglia
15) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0 Pain Relevance 0.06
In an attempt to mimic the accepted TRAPS 'phenotype' of impaired receptor shedding, Xanthoulea and colleagues created a knock-in mouse that expressed a nonsheddable form of TNFR1 [53].
Gene_expression (expressed) of TNFR1 associated with targeted disruption and tumor necrosis factor receptor-associated periodic syndrome
16) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.71 Pain Relevance 0.19
TNFR1 in mouse DRG neurons is detected after sciatic nerve injury but not in control mice [27].
Neg (not) Gene_expression (detected) of TNFR1 in sciatic nerve associated with dorsal root ganglion, nervous system injury and sciatic nerve
17) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.04 Pain Relevance 0.63
In order to explore expression of TNFR1 in mouse DRG neurons after capsaicin stimulation, we first examined the co-localization of TRPV1 with TNFR1.
Gene_expression (expression) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
18) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.73 Pain Relevance 0.74
Whereas Sag exposure did not induce alterations in the expression of Bcl-2, TRAIL or TNFR1, interaction of Sags with the cognate V?
Gene_expression (expression) of TNFR1
19) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.05 Pain Relevance 0
Exposure to specific bacterial Sags did not induced alterations in Bcl-2 expression or in the level of expression of TNFR1 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (data not shown).
Gene_expression (expression) of TNFR1 associated with necrosis, cancer and apoptosis
20) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.58 Pain Relevance 0

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