INT93739

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 11.17
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf1a) extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a)
plasma membrane (Tnfrsf1a) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)
Anatomy Link Frequency
tears 2
lymphocytes 2
nerve 2
neurons 2
brains 2
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 61 100.00 Very High Very High Very High
qutenza 183 99.72 Very High Very High Very High
Inflammation 186 99.50 Very High Very High Very High
agonist 34 99.36 Very High Very High Very High
Dopamine 7 99.12 Very High Very High Very High
dorsal root ganglion 150 98.52 Very High Very High Very High
Hyperalgesia 24 96.00 Very High Very High Very High
Nerve growth factor 4 95.40 Very High Very High Very High
Sciatic nerve 3 89.92 High High
spinal inflammation 6 84.24 Quite High
Disease Link Frequency Relevance Heat
Adhesions 11 100.00 Very High Very High Very High
Nervous System Injury 12 99.82 Very High Very High Very High
Neurodegenerative Disease 21 99.80 Very High Very High Very High
Coronary Artery Disease 20 99.68 Very High Very High Very High
INFLAMMATION 202 99.50 Very High Very High Very High
Disorders Of The Lacrimal System 61 99.48 Very High Very High Very High
Disease 292 98.88 Very High Very High Very High
Ganglion Cysts 154 98.52 Very High Very High Very High
Lymphatic System Cancer 95 98.24 Very High Very High Very High
Apoptosis 79 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat inflammation or nerve injury models, increases in TNFR1 expression are reported by several other researchers [15,17,28-30].
Positive_regulation (increases) of Gene_expression (expression) of TNFR1 in nerve associated with nervous system injury and inflammation
1) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.01 Pain Relevance 0.58
The TNFR1 staining increase after capsaicin (1 ?
Positive_regulation (increase) of Gene_expression (staining) of TNFR1 associated with qutenza
2) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.48 Pain Relevance 1.07
is released, and TNFR1 expression in neurons is increasing in proportion to the changes in TNF-?
Positive_regulation (increasing) of Gene_expression (expression) of TNFR1 in neurons
3) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.17 Pain Relevance 0.80
1-agonist on pure OGD and in hippocampal slices devoid of TNFR1 and TNFR2
Positive_regulation (slices) of Gene_expression (devoid) of TNFR1 associated with agonist
4) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.14 Pain Relevance 0.05
Whereas Sag exposure did not induce alterations in the expression of Bcl-2, TRAIL or TNFR1, interaction of Sags with the cognate V?
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of TNFR1
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.06 Pain Relevance 0
As in many other neurodegenerative diseases, TNF and solTNFR1 levels are elevated in cerebrospinal fluid and tissues of PD patients as well as in postmortem PD brains with the highest TNF levels present in areas that have the greatest loss of dopaminergic neurons [78-81].
Positive_regulation (elevated) of Gene_expression (levels) of solTNFR1 in brains associated with disease and neurodegenerative disease
6) Confidence 0.33 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.51 Pain Relevance 0.09
Selective expression of TNFRI on these cells seems to be sufficient to orchestrate the complete development of SpA-related pathologies at least in TNF(DeltaARE) mice.
Spec (seems) Positive_regulation (sufficient) of Gene_expression (expression) of TNFRI
7) Confidence 0.33 Published 2009 Journal Dig Dis Section Abstract Doc Link 19897967 Disease Relevance 1.04 Pain Relevance 0.47
-mediated signaling is TNFR1 and TRADD, a TNF receptor adaptor protein that allows for NF-?
Positive_regulation (mediated) of Gene_expression (signaling) of TNFR1
8) Confidence 0.31 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.68 Pain Relevance 0.28
Increased levels of TNFR1 and decreased levels of TNFR2 have been observed in AD brains and in peripheral lymphocytes from older adults compared with younger adults though others say that the receptors may not play a major role in the development of AD [129-131].
Positive_regulation (Increased) of Gene_expression (levels) of TNFR1 in lymphocytes associated with disease
9) Confidence 0.20 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.73 Pain Relevance 0.16
Furthermore, the levels of TNF-alpha receptor R1 (TNF-R1, p55), bcl-2, soluble Fas (sFas), and the activities of caspase-1 and caspase-3 were also elevated in the nigrostriatal DA regions in PD.
Positive_regulation (elevated) of Gene_expression (levels) of TNF-R1 associated with dopamine and disease
10) Confidence 0.07 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.16 Pain Relevance 0.63
Adenovirus-mediated transfer of the TNFRp55-Ig gene to the lacrimal gland resulted in expression of the transgene product and its secretion into tears.
Positive_regulation (transfer) of Gene_expression (transfer) of TNFRp55-Ig in tears associated with disorders of the lacrimal system
11) Confidence 0.01 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1187915 Disease Relevance 0.98 Pain Relevance 0
Interventional procedures resulted in suppression of both cytokine (TNF-alpha, sTNFR 2) and adhesion molecule (sE-selectin, sP-selectin) activation in the CAD group.
Positive_regulation (activation) of Gene_expression (suppression) of sTNFR 2 associated with coronary artery disease, adhesions and cytokine
12) Confidence 0.01 Published 2006 Journal Heart Vessels Section Abstract Doc Link 17151818 Disease Relevance 1.20 Pain Relevance 0.30

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