INT93744

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.91
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Dpp4) extracellular region (Dpp4) cell adhesion (Dpp4)
Golgi apparatus (Dpp4) endoplasmic reticulum (Dpp4) plasma membrane (Dpp4)
Anatomy Link Frequency
dorsal root ganglia 2
livers 1
Dpp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 5 100.00 Very High Very High Very High
antagonist 1 98.22 Very High Very High Very High
Inflammation 2 96.80 Very High Very High Very High
cINOD 2 95.48 Very High Very High Very High
Dynorphin 7 93.72 High High
Hyperalgesia 6 78.72 Quite High
substance P 2 77.56 Quite High
Potency 1 76.32 Quite High
Antihyperalgesic 4 75.00 Quite High
Endogenous opioid 1 70.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 96.80 Very High Very High Very High
Hyperalgesia 6 78.72 Quite High
Nociception 4 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both monoclonal antibodies recognized DPP IV in livers from ZP- and vehicle-dosed rats.
DPP IV Binding (recognized) of in livers
1) Confidence 0.48 Published 2001 Journal Life Sci. Section Abstract Doc Link 11205870 Disease Relevance 0.15 Pain Relevance 0.11
Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac.
peptidase IV Binding (target) of associated with inflammation
2) Confidence 0.37 Published 2001 Journal Life Sci. Section Title Doc Link 11205870 Disease Relevance 0.19 Pain Relevance 0.14
We have found recently that membrane-bound dipeptidyl peptidase IV (DPP-IV) generated extracellularly immunoreactive endomorphin-2 from Tyr-Pro precursor in a depolarisation-sensitive manner in rat isolated L4,5 dorsal root ganglia when the enzyme was switched to synthase mode by the hydrolase inhibitor Ile-Pro-Ile.
DPP-IV Binding (bound) of in dorsal root ganglia
3) Confidence 0.34 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19695241 Disease Relevance 0.28 Pain Relevance 0.33
We have found recently that membrane-bound dipeptidyl peptidase IV (DPP-IV) generated extracellularly immunoreactive endomorphin-2 from Tyr-Pro precursor in a depolarisation-sensitive manner in rat isolated L4,5 dorsal root ganglia when the enzyme was switched to synthase mode by the hydrolase inhibitor Ile-Pro-Ile.
peptidase IV Binding (bound) of in dorsal root ganglia
4) Confidence 0.34 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19695241 Disease Relevance 0.28 Pain Relevance 0.30
DPPIV down-regulation was also resistent to KOR antagonist, NBI, suggesting that the mechanism underlying the observed phenomenon involves neither cointernalization of KOR and DPPIV.
DPPIV Neg (neither) Binding (cointernalization) of associated with antagonist and kappa opioid receptor
5) Confidence 0.21 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.72

General Comments

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