INT93753

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.31
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Tap2) endoplasmic reticulum (Tap2) ATPase activity (Tap2)
plasma membrane (Tap2) nucleus (Tap2) protein complex assembly (Tap2)
Anatomy Link Frequency
plasma 1
Tap2 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 6 98.72 Very High Very High Very High
Analgesic 2 98.60 Very High Very High Very High
Inflammation 6 98.32 Very High Very High Very High
analgesia 2 97.64 Very High Very High Very High
Neuropathic pain 2 95.24 Very High Very High Very High
Pain 8 92.88 High High
Hyperalgesia 2 90.68 High High
Dorsal horn 2 75.20 Quite High
Neuropeptide 4 75.00 Quite High
antinociception 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 4 98.32 Very High Very High Very High
Neuropathic Pain 2 95.24 Very High Very High Very High
Hypersensitivity 2 94.52 High High
Pain 6 92.88 High High
Hyperalgesia 2 90.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the periphery, Y1 receptor activation is sufficient and required for substance P release and the subsequent development of neurogenic inflammation and plasma leakage.
Positive_regulation (activation) of Y1 in plasma associated with inflammation, neurogenic inflammation and substance p
1) Confidence 0.57 Published 2001 Journal Nature Section Abstract Doc Link 11206547 Disease Relevance 0.63 Pain Relevance 1.12
We conclude that the Y1 receptor is required for central physiological and pharmacological NPY-induced analgesia and that its activation is both sufficient and required for the release of substance P and initiation of neurogenic inflammation.
Positive_regulation (required) of Y1 associated with inflammation, neurogenic inflammation, substance p and analgesia
2) Confidence 0.41 Published 2001 Journal Nature Section Abstract Doc Link 11206547 Disease Relevance 0.68 Pain Relevance 1.09

General Comments

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