INT93753

Context Info Confidence 0.57 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.31 Pain Relevance 2.21

transport (Tap2) endoplasmic reticulum (Tap2) ATPase activity (Tap2) plasma membrane (Tap2) nucleus (Tap2) protein complex assembly (Tap2)

Anatomy Link Frequency plasma 1 Tap2 (Mus musculus)

Pain Link Frequency Relevance Heat substance P 6 98.72 Analgesic 2 98.60 Inflammation 6 98.32 analgesia 2 97.64 Neuropathic pain 2 95.24 Pain 8 92.88 Hyperalgesia 2 90.68 Dorsal horn 2 75.20 Neuropeptide 4 75.00 antinociception 2 75.00

Disease Link Frequency Relevance Heat Neurogenic Inflammation 4 98.32 Neuropathic Pain 2 95.24 Hypersensitivity 2 94.52 Pain 6 92.88 Hyperalgesia 2 90.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the periphery, Y1 receptor activation is sufficient and required for substance P release and the subsequent development of neurogenic inflammation and plasma leakage.

Positive_regulation (activation) of Y1 in plasma associated with inflammation, neurogenic inflammation and substance p

1) Confidence 0.57 Published 2001 Journal Nature Section Abstract Doc Link 11206547 Disease Relevance 0.63 Pain Relevance 1.12

We conclude that the Y1 receptor is required for central physiological and pharmacological NPY-induced analgesia and that its activation is both sufficient and required for the release of substance P and initiation of neurogenic inflammation.

Positive_regulation (required) of Y1 associated with inflammation, neurogenic inflammation, substance p and analgesia

2) Confidence 0.41 Published 2001 Journal Nature Section Abstract Doc Link 11206547 Disease Relevance 0.68 Pain Relevance 1.09

General Comments

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