INT93758

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.73
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (COX18) mitochondrion (COX18)
Anatomy Link Frequency
chondrocyte 1
COX18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 91.72 High High
Inflammation 22 75.00 Quite High
Osteoarthritis 44 37.68 Quite Low
COX2 6 25.00 Low Low
Pain 3 25.00 Low Low
cOX1 1 25.00 Low Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
licofelone 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 7 99.84 Very High Very High Very High
Metastasis 10 98.88 Very High Very High Very High
Reprotox - General 1 4 97.48 Very High Very High Very High
Apoptosis 7 96.16 Very High Very High Very High
INFLAMMATION 31 91.48 High High
Glioma 2 83.80 Quite High
Colon Cancer 5 83.32 Quite High
Esophageal Cancer 2 75.00 Quite High
Frailty 2 75.00 Quite High
Prostate Cancer 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diffuse cytoplasmic staining for COX-2 protein was detected in cancer cells in 100% of metastases (COX-2 score 1, n = 25; score 2, n = 29).
Transcription (detected) of COX-2 protein associated with cancer and metastasis
1) Confidence 0.34 Published 2000 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11206834 Disease Relevance 1.15 Pain Relevance 0.08
NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.
Transcription (levels) of COX-2 protein
2) Confidence 0.19 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.82 Pain Relevance 0.13
As described in our previous report [20], COX-2 protein and mRNA expression decreased gradually after 8 hours of chondrocyte incubation with single addition of 10 ?
Transcription (expression) of COX-2 protein in chondrocyte
3) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
In this report, we examine the expression of COX-2 protein and mRNA in prostate tissue containing various lesions and in prostate cancer cell lines.
Spec (examine) Transcription (expression) of COX-2 protein associated with reprotox - general 1
4) Confidence 0.11 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11751373 Disease Relevance 0.60 Pain Relevance 0.13
By immunoblotting and reverse-transcription polymerase chain reaction, we showed that gamma-mangostin concentration-dependently inhibited lipopolysaccharide (LPS)-induced expression of COX-2 protein and its mRNA, but not those of constitutive COX-1 cyclooxygenase.
Transcription (expression) of COX-2 protein
5) Confidence 0.02 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.16 Pain Relevance 0

General Comments

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