INT9377

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 43
Total Number 44
Disease Relevance 15.81
Pain Relevance 24.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
keratinocytes 8
neurons 4
sensory nerve 4
dorsal root ganglia 4
C16 2
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 196 100.00 Very High Very High Very High
substance P 75 100.00 Very High Very High Very High
agonist 37 100.00 Very High Very High Very High
Kinase C 24 100.00 Very High Very High Very High
Calcitonin gene-related peptide 22 100.00 Very High Very High Very High
nociceptor 11 100.00 Very High Very High Very High
vanilloid receptor subtype 1 9 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
burning pain 2 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 58 100.00 Very High Very High Very High
Pain 58 100.00 Very High Very High Very High
Neurogenic Inflammation 10 99.96 Very High Very High Very High
Hyperalgesia 30 99.92 Very High Very High Very High
Esophageal Disease 44 99.86 Very High Very High Very High
Ganglion Cysts 14 99.72 Very High Very High Very High
Neuropathic Pain 26 99.64 Very High Very High Very High
Increased Venous Pressure Under Development 8 99.56 Very High Very High Very High
Shock 24 99.42 Very High Very High Very High
Inflammatory Pain 4 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that exposure to oxidizing agents also enhances the heat-induced activation of TRPV1.
Positive_regulation (enhances) of Positive_regulation (activation) of TRPV1
1) Confidence 0.70 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16614139 Disease Relevance 0 Pain Relevance 0
Our findings suggest that topical application of capsaicin to the airway induces IL-6 production from respiratory epithelial cells via activation of TRPV1.
Positive_regulation (induces) of Positive_regulation (activation) of TRPV1 in respiratory associated with qutenza
2) Confidence 0.69 Published 2007 Journal Life Sci. Section Abstract Doc Link 17306835 Disease Relevance 0.11 Pain Relevance 0.51
On the other hand, no activation of TRPV1 was induced by MGs having C16 and C18 saturated FA, di- or triacylglycerols of C18:1 FA.
Positive_regulation (induced) of Neg (no) Positive_regulation (activation) of TRPV1 in C16
3) Confidence 0.69 Published 2008 Journal Lipids Section Abstract Doc Link 18481133 Disease Relevance 0.09 Pain Relevance 0.74
To our knowledge, only one study has demonstrated increased TRPV1 immunoreactivity in a patient with painful neuropathy (postherpetic neuralgia).22 It is interesting to note that although the authors report a somewhat patchy increase of IENF with increased TRPV1, the immunofluorescence also seems clearly to show increased keratinocyte expression in the skin afflicted with neuropathy.
Positive_regulation (increase) of Positive_regulation (increased) of TRPV1 in keratinocyte associated with pain, neuropathic pain and postherpetic neuralgia
4) Confidence 0.50 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 1.14 Pain Relevance 0.72
Furthermore, direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased MMP-1 expression.
Positive_regulation (increased) of Positive_regulation (activation) of TRPV1 associated with qutenza, metalloproteinase and agonist
5) Confidence 0.50 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.69 Pain Relevance 0.53
Taken together, our results suggest that heat-shock-induced MMP-1 expression is mediated by activation of TRPV1 and is dependent on a calcium-dependent signaling process in human epidermal keratinocytes.
Positive_regulation (mediated) of Positive_regulation (activation) of TRPV1 in keratinocytes associated with shock and metalloproteinase
6) Confidence 0.50 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.65 Pain Relevance 0.49
Transient receptor potential vanilloid-1 (TRPV1), a heat-gated channel, was recently found on human keratinocytes and the activation of epidermal TRPV1 was known to induce release of proinflammatory mediators.
Positive_regulation (induce) of Positive_regulation (activation) of TRPV1 in keratinocytes
7) Confidence 0.50 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.28 Pain Relevance 0.18
The results from this study provide the first evidence indicating that activation of TRPV1 receptors increases the neuronal activity of the dl-PAG through selective potentiation of glutamatergic synaptic inputs.
Positive_regulation (increases) of Positive_regulation (activation) of TRPV1 in neuronal associated with urological neuroanatomy
8) Confidence 0.50 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17065246 Disease Relevance 0.55 Pain Relevance 0.49
Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation?
Positive_regulation (Surfactant-induced) of Positive_regulation (induced) of TRPV1 in eye associated with qutenza
9) Confidence 0.50 Published 2007 Journal Toxicol. Sci. Section Title Doc Link 17575321 Disease Relevance 0.43 Pain Relevance 0.64
Activation of TRPV1 in nociceptive neurons results in the release of neuropeptides and transmitters, leading to the generation of action potentials that will be sent to higher CNS areas, where they will often be perceived as pain.
Positive_regulation (results) of Positive_regulation (Activation) of TRPV1 in neurons associated with nociception, pain, action potential and neuropeptide
10) Confidence 0.50 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20336426 Disease Relevance 0.72 Pain Relevance 0.58
PDBu was antagonized by bisindolylmaleimide, a PKC inhibitor, and ruthenium red, a VR1 ionophore blocker, but not capsazepine, a vanilloid antagonist indicating that catalytic activity of PKC is required for PDBu activation of VR1 ion conductance, and is independent of the vanilloid site.
Positive_regulation (required) of Positive_regulation (activation) of VR1 associated with kinase c and antagonist
11) Confidence 0.50 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12095983 Disease Relevance 0.17 Pain Relevance 0.58
The ensuing research established that the neuropharmacological properties of capsaicin are due to its activation of the transient receptor potential ion channel of the vanilloid type 1 (TRPV1).
Positive_regulation (due) of Positive_regulation (activation) of TRPV1 associated with qutenza
12) Confidence 0.50 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464036 Disease Relevance 0.47 Pain Relevance 0.70
This process is initiated by TRPV1 receptor activation and the subsequent entry of extracellular Ca(2+) through the channel into sensory neurones.
Positive_regulation (initiated) of Positive_regulation (activation) of TRPV1 receptor
13) Confidence 0.49 Published 2007 Journal Neuroscience Section Abstract Doc Link 17869438 Disease Relevance 0.20 Pain Relevance 0.25
Additionally, activation of VR-1 at its optimal temperature of 46 degrees C caused a significant increase in virus titres, which could be attenuated with the VR-1 antagonist, capsazepine.
Positive_regulation (increase) of Positive_regulation (activation) of VR-1 associated with antagonist
14) Confidence 0.49 Published 2003 Journal J. Gen. Virol. Section Abstract Doc Link 12692270 Disease Relevance 0.66 Pain Relevance 0.56
In rat dorsal root ganglia slices, AEA-induced release of substance P, an effect mediated by VR1 activation, was enhanced three-fold by FRSK (10 nM).
Positive_regulation (mediated) of Positive_regulation (activation) of VR1 in dorsal root ganglia associated with substance p
15) Confidence 0.49 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11413249 Disease Relevance 0 Pain Relevance 0.26
TRPV1 is now believed to function as a molecular integrator of noxious stimuli, including acids, heat, pollutants with negative electric charge and endogenous pro-inflammatory substances.16 Up-regulated TRPV1 expression has been demonstrated in disease states of the gastrointestinal tract such as inflammatory bowel disease,17 irritable bowel syndrome18 and, more recently, esophagitis.19,20 TRPV1 activation in primary afferent neurons evokes the sensation of burning pain and induces neurogenic inflammation by the release of substance P (SP) and calcitonin-gene-related peptide (CGRP).17,21

2.

Positive_regulation (induces) of Positive_regulation (activation) of TRPV1 in bowel associated with calcitonin gene related peptide, esophageal disease, inflammation, neurogenic inflammation, disease, substance p and burning pain
16) Confidence 0.48 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.09 Pain Relevance 0.85
Production of PAF in esophageal epithelial cells, in response to TRPV1 activation has been confirmed in the human esophageal epithelial cell line HET-1A, where the sequential steps beginning with TRPV1 receptor activation and resulting in PAF production has been elucidated.56

6.

Positive_regulation (response) of Positive_regulation (activation) of TRPV1 in epithelial cells
17) Confidence 0.48 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0 Pain Relevance 0.11
ROS activation of TRPV1 on vascular membranes also increases local blood flow [15].
Positive_regulation (increases) of Positive_regulation (activation) of TRPV1 in blood
18) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.68 Pain Relevance 0.56
The TRPV1 induced increase in COX-2 staining was reduced by pre-treatment with either TRPV1 antagonist capsazepine (5 ?
Positive_regulation (induced) of Positive_regulation (increase) of TRPV1 associated with antagonist
19) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.21 Pain Relevance 0.25
In conclusion, CB1 and TRPV1 activation induces increases in HCEC proliferation and migration through EGFR transactivation leading to global MAPK and Akt/PI-3K pathway stimulation.
Positive_regulation (increases) of Positive_regulation (activation) of TRPV1 in HCEC associated with cannabinoid receptor
20) Confidence 0.47 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.06 Pain Relevance 0.50

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