INT93777

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.50
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rgs2) plasma membrane (Rgs2) nucleus (Rgs2)
cell cycle (Rgs2) cytoplasm (Rgs2)
Anatomy Link Frequency
blood 2
Rgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 2 99.76 Very High Very High Very High
Opioid 12 98.00 Very High Very High Very High
antinociception 2 97.72 Very High Very High Very High
analgesia 2 97.24 Very High Very High Very High
Morphine 12 96.08 Very High Very High Very High
tolerance 8 89.84 High High
mu opioid receptor 4 89.76 High High
agonist 17 74.48 Quite High
opioid receptor 2 51.84 Quite High
antagonist 3 51.64 Quite High
Disease Link Frequency Relevance Heat
Ocular Hypertension 210 100.00 Very High Very High Very High
Aggression 3 98.34 Very High Very High Very High
Anxiety Disorder 3 98.10 Very High Very High Very High
Congenital Anomalies 3 97.50 Very High Very High Very High
Targeted Disruption 11 94.44 High High
Glaucoma 24 94.08 High High
Ganglion Cysts 84 72.96 Quite High
Aging 12 50.96 Quite High
Stress 6 43.36 Quite Low
Open-angle Glaucoma 3 12.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, in the published work, although these mice have been shown to exhibit abnormalities in T-cell activation, anxiety, aggression, and blood pressure, there are no known developmental changes associated with the deficiency of RGS2 [13].
Negative_regulation (deficiency) of RGS2 in blood associated with congenital anomalies, aggression and anxiety disorder
1) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2650719 Disease Relevance 1.03 Pain Relevance 0.03
Moreover, this decreased IOP in the RGS2?
Negative_regulation (decreased) of RGS2 associated with ocular hypertension
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2650719 Disease Relevance 1.09 Pain Relevance 0.05
Because TM and CM are smooth muscle-like, we hypothesized that regulator of G-protein signaling 2 (RGS2), a regulatory protein that promotes vascular smooth muscle relaxation and blood pressure homeostasis [12-15], might control IOP.
Negative_regulation (regulator) of RGS2 in blood associated with ocular hypertension
3) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2650719 Disease Relevance 0.19 Pain Relevance 0.07
In mice with impaired RGS9, but not impaired RGS2, the potency and, in particular, the duration of opioid antinociception increased.
Negative_regulation (impaired) of RGS2 associated with antinociception, opioid and potency
4) Confidence 0.38 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11207815 Disease Relevance 0.09 Pain Relevance 1.33
In mice with impaired RGS9, but not impaired RGS2, the potency and, in particular, the duration of opioid antinociception increased.
Negative_regulation (impaired) of RGS2 associated with antinociception, opioid and potency
5) Confidence 0.38 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11207815 Disease Relevance 0.09 Pain Relevance 1.33

General Comments

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