INT93778

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.32
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gnptab) Golgi apparatus (Gnptab) nucleus (Gnptab)
transcription factor binding (Gnptab)
Anatomy Link Frequency
brain 1
Gnptab (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
opioid receptor 1 98.30 Very High Very High Very High
mu opioid receptor 2 98.00 Very High Very High Very High
tolerance 4 93.28 High High
agonist 1 89.68 High High
Opioid 6 88.60 High High
antinociception 1 74.76 Quite High
Potency 1 72.40 Quite High
analgesia 1 67.68 Quite High
Hsan 1 41.20 Quite Low
Disease Link Frequency Relevance Heat
Stress 9 100.00 Very High Very High Very High
Ataxia 1 81.68 Quite High
Dystonia 1 74.44 Quite High
Targeted Disruption 4 64.88 Quite High
Clinical Trials And Case Reports 1 50.00 Quite Low
Hereditary Sensory And Autonomic Neuropathies 1 41.20 Quite Low
Neuropathic Pain 1 33.44 Quite Low
Shock 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To reduce the impact of the chronic morphine acting on opioid receptors, other RGS proteins presumably substitute the GTPase-activating function of RGS9 on morphine-activated G-alpha-GTP subunits.
Positive_regulation (morphine-activated) of subunits associated with opioid receptor and morphine
1) Confidence 0.02 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11207815 Disease Relevance 0.06 Pain Relevance 1.47
In general, these genes are uniformly expressed across brain regions (Figure 8) and are either abundantly expressed (6 of 14 in the top 20th percentile) or poorly expressed (6 of 14 in the bottom 20th percentile); Cct subunits are not stress inducible.
Neg (not) Positive_regulation (inducible) of subunits in brain associated with stress
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.26 Pain Relevance 0

General Comments

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