INT93789

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Context Info
Confidence 0.76
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 28
Total Number 36
Disease Relevance 17.30
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscles 7
blood 1
cardiac myocytes 1
neurons 1
extracellular matrix 1
Tnnc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 207 99.00 Very High Very High Very High
Inflammatory response 38 97.12 Very High Very High Very High
Angina 119 95.92 Very High Very High Very High
Opioid 10 95.52 Very High Very High Very High
ischemia 156 93.60 High High
Percutaneous transluminal coronary angioplasty 5 91.72 High High
depression 6 86.76 High High
cva 93 82.96 Quite High
isoflurane 21 76.96 Quite High
cytokine 99 75.68 Quite High
Disease Link Frequency Relevance Heat
Reperfusion Injury 371 99.98 Very High Very High Very High
Pyometra 340 99.70 Very High Very High Very High
Acute Coronary Syndrome 42 99.16 Very High Very High Very High
Necrosis 26 99.16 Very High Very High Very High
INFLAMMATION 222 99.00 Very High Very High Very High
Myocardial Infarction 113 98.92 Very High Very High Very High
Cv General 3 Under Development 34 98.68 Very High Very High Very High
Fatigue 64 98.62 Very High Very High Very High
Hypertension 24 97.92 Very High Very High Very High
Systemic Inflammatory Response Syndrome 340 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lower limit of detection of cTnI in our assay is 0,2 ?
Gene_expression (detection) of cTnI
1) Confidence 0.76 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.36 Pain Relevance 0
Two (13%) of the control dogs had increased cTnI concentrations the day after surgery (0.4 and 3 ?
Gene_expression (concentrations) of cTnI
2) Confidence 0.66 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.66 Pain Relevance 0
Thirteen (28%) of the dogs had increased cTnI concentrations (> 0.2 ?
Gene_expression (concentrations) of cTnI
3) Confidence 0.66 Published 2008 Journal Acta Vet Scand Section Abstract Doc Link PMC2546406 Disease Relevance 1.01 Pain Relevance 0.17
Comparison of cTnI concentrations and clinical parameters
Gene_expression (concentrations) of cTnI
4) Confidence 0.66 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.89 Pain Relevance 0
Thus, in total, 20 dogs (43%) with pyometra had increased cTnI concentrations before or after surgery, and 7 dogs had pre- or postoperative cTnI concentrations of 1.0 ?
Gene_expression (concentrations) of cTnI associated with pyometra
5) Confidence 0.66 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.47 Pain Relevance 0
When cardiac myocytes are damaged, cTnI leaks into the bloodstream and can be detected in serum [1,3].
Gene_expression (detected) of cTnI in cardiac myocytes
6) Confidence 0.59 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.89 Pain Relevance 0.19
Seven dogs (15%) had pre-or postoperative concentrations of cTnI of 1.0 ?
Gene_expression (concentrations) of cTnI
7) Confidence 0.57 Published 2008 Journal Acta Vet Scand Section Abstract Doc Link PMC2546406 Disease Relevance 0.49 Pain Relevance 0.03
Haematology, cTnI analysis and blood biochemistry
Gene_expression (analysis) of cTnI in blood
8) Confidence 0.57 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.07 Pain Relevance 0.23
Preoperative cTnI-concentrations
Gene_expression (Preoperative) of cTnI
9) Confidence 0.57 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.65 Pain Relevance 0
Postoperative cTnI concentrations
Gene_expression (concentrations) of cTnI
10) Confidence 0.57 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.67 Pain Relevance 0
Although increased cTnI or cTnT values always indicate myocardial tissue damage, a positive test is not able to identify the mechanism responsible for that cardiac damage (which could be not due to ischemia).
Gene_expression (values) of cTnI associated with ischemia
11) Confidence 0.57 Published 2009 Journal Adv Clin Chem Section Abstract Doc Link 19947353 Disease Relevance 0.82 Pain Relevance 0.14
The aim of this study was to determine the prognostic implications of intermediate serum cTnI levels in patients without ACS in the intensive care unit (ICU).
Gene_expression (levels) of cTnI associated with acute coronary syndrome
12) Confidence 0.54 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18721503 Disease Relevance 0.62 Pain Relevance 0.10
AIM: To determine whether our use of troponin I (cTnI) in routine clinical practice conforms to ideal standards.
Spec (whether) Gene_expression (use) of cTnI
13) Confidence 0.49 Published 2005 Journal QJM Section Body Doc Link 15820972 Disease Relevance 0 Pain Relevance 0
There were 2 cases with acute blunt cardiac trauma and intracranial hemorrhage, respectively, that produced cTnI results that were initially low (<0.04 and 0.05 microg/l, respectively), but significantly increased with serial testing thereby producing false positive Delta cTnI results for AMI.
Gene_expression (producing) of cTnI
14) Confidence 0.41 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 19135041 Disease Relevance 0 Pain Relevance 0
There were 2 cases with acute blunt cardiac trauma and intracranial hemorrhage, respectively, that produced cTnI results that were initially low (<0.04 and 0.05 microg/l, respectively), but significantly increased with serial testing thereby producing false positive Delta cTnI results for AMI.
Gene_expression (produced) of cTnI
15) Confidence 0.41 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 19135041 Disease Relevance 0.05 Pain Relevance 0
Since endogenous TnC, unlike calmodulin, is not expressed in neurons, TnC-based sensors may show reduced interference with endogenous signal transduction processes in neurons [21].
Neg (not) Gene_expression (expressed) of TnC in neurons
16) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262942 Disease Relevance 0.07 Pain Relevance 0.03
DESIGN AND METHODS: The cardiac troponin I forms released in the bloodstream of 25 patients suffering from unstable angina were examined by using three immunoenzymatic assays: the total cTnI assay for detection of free and complexed cTnI, the IC-TIC assay for detection of the IC and TIC troponin complexes, and the IT-TIC assay for detection of the IT and TIC troponin complexes.
Gene_expression (detection) of cTnI
17) Confidence 0.20 Published 2002 Journal Clin. Biochem. Section Body Doc Link 11983345 Disease Relevance 0.09 Pain Relevance 0
DESIGN AND METHODS: The cardiac troponin I forms released in the bloodstream of 25 patients suffering from unstable angina were examined by using three immunoenzymatic assays: the total cTnI assay for detection of free and complexed cTnI, the IC-TIC assay for detection of the IC and TIC troponin complexes, and the IT-TIC assay for detection of the IT and TIC troponin complexes.
Gene_expression (detection) of cTnI
18) Confidence 0.20 Published 2002 Journal Clin. Biochem. Section Body Doc Link 11983345 Disease Relevance 0.09 Pain Relevance 0
Both myoglobin and hFABP also performed poorly in those patients who were cTnI negative on admission.
Neg (negative) Gene_expression (negative) of cTnI
19) Confidence 0.14 Published 2004 Journal Ann. Clin. Biochem. Section Body Doc Link 15333191 Disease Relevance 0.06 Pain Relevance 0
None of the patients had abnormal cTnI or cTnT levels, CK activity, or CKMB levels before the procedures.
Gene_expression (levels) of cTnI
20) Confidence 0.12 Published 2000 Journal Med. Sci. Monit. Section Abstract Doc Link 11208396 Disease Relevance 0.45 Pain Relevance 0.29

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