INT9381

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2011
Negated 15
Speculated 11
Reported most in Abstract
Documents 523
Total Number 544
Disease Relevance 187.40
Pain Relevance 276.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
nerve 22
sensory neurons 22
neurons 14
keratinocytes 14
dorsal root ganglia 10
TRPV1 (Homo sapiens)
TRPV1 - P91S (2) TRPV1 - I315M (2)
Pain Link Frequency Relevance Heat
qutenza 3458 100.00 Very High Very High Very High
Pain 2313 100.00 Very High Very High Very High
Inflammation 2267 100.00 Very High Very High Very High
spastic colon 1399 100.00 Very High Very High Very High
antagonist 960 100.00 Very High Very High Very High
agonist 924 100.00 Very High Very High Very High
substance P 653 100.00 Very High Very High Very High
Calcitonin gene-related peptide 387 100.00 Very High Very High Very High
TRP channel 373 100.00 Very High Very High Very High
dorsal root ganglion 326 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 2419 100.00 Very High Very High Very High
INFLAMMATION 2239 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1451 100.00 Very High Very High Very High
Nociception 695 100.00 Very High Very High Very High
Ganglion Cysts 482 100.00 Very High Very High Very High
Hyperalgesia 382 100.00 Very High Very High Very High
Inflammatory Pain 149 99.92 Very High Very High Very High
Injury 455 99.86 Very High Very High Very High
Esophageal Disease 245 99.86 Very High Very High Very High
Neuropathic Pain 472 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time PCR analysis also showed that the mRNA level of TRPV1 was augmented by 2.4-fold at 4 h after UV irradiation.
Positive_regulation (augmented) of TRPV1
1) Confidence 0.70 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.16 Pain Relevance 0.07
Transient receptor potential vanilloid type 1 (TRPV1) is activated by various stimuli including capsaicin, heat and acid.
Positive_regulation (activated) of TRPV1 associated with qutenza
2) Confidence 0.70 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.16 Pain Relevance 0.10
By contrast, we observed a dramatically elevated TRPV1-immunoreactivity in all layers of the epithelium both in precancerous and malignant samples.
Positive_regulation (elevated) of TRPV1-immunoreactivity in epithelium
3) Confidence 0.70 Published 2009 Journal Oral Dis Section Body Doc Link 19320840 Disease Relevance 0.26 Pain Relevance 0
Capsaicin activates the transient receptor potential vanilloid 1 receptor (TRPV1) on small sensory afferents, and capsaicin is commonly used to elucidate mechanisms of neuropathic pain.
Positive_regulation (activates) of TRPV1 associated with qutenza and neuropathic pain
4) Confidence 0.70 Published 2008 Journal Exp Brain Res Section Abstract Doc Link 18709364 Disease Relevance 0.31 Pain Relevance 0.79
In summary, our results identify a novel group of compounds that activate TRPV1 and, consequently, provide a molecular mechanism that may account for off tastes of sweeteners and metallic tasting salts.
Positive_regulation (activate) of TRPV1
5) Confidence 0.70 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17567713 Disease Relevance 0.25 Pain Relevance 0.04
Here, we show that exposure to oxidizing agents also enhances the heat-induced activation of TRPV1.
Positive_regulation (activation) of TRPV1
6) Confidence 0.70 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16614139 Disease Relevance 0 Pain Relevance 0
We have previously reported that the reducing agent dithiothreitol (DTT) strongly increases thermally induced activity of the transient receptor potential vanilloid receptor-1 (TRPV1) channel.
Positive_regulation (increases) of TRPV1
7) Confidence 0.70 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16614139 Disease Relevance 0 Pain Relevance 0
Hence, TRPV1 activation could be involved in the AS aftertaste or even contribute to the poorly understood metallic taste sensation.
Positive_regulation (activation) of TRPV1 associated with taste disorders
8) Confidence 0.70 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17567713 Disease Relevance 0.23 Pain Relevance 0.05
Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety.
Positive_regulation (activation) of VR1
9) Confidence 0.70 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 12166946 Disease Relevance 0 Pain Relevance 0.10
Our study results indicate that VR1 immunoreactivity is greatly increased in colonic nerve fibres of patients with active inflammatory bowel disease.
Positive_regulation (increased) of VR1 in bowel associated with inflammation
10) Confidence 0.70 Published 2001 Journal Lancet Section Abstract Doc Link 11343743 Disease Relevance 0.47 Pain Relevance 0.40
The association of increased keratinocyte TRPV1 in human conditions with pain has recently been demonstrated in women with breast pain, in patients with rectal hypersensitivity and faecal urgency, as well as in pruritic skin of patients with prurigo nodularis.8,23,24 We recently described a patient with steroid-responsive small nerve fibre symptoms of burning feet and hands, where keratinocytes showed strong TRPV1 expression.25 On follow-up skin biopsy after steroid administration, keratinocyte TRPV1 expression was drastically reduced in parallel with remission of clinical symptoms (manuscript in preparation).
Positive_regulation (increased) of TRPV1 in keratinocytes associated with pain and pruritus
11) Confidence 0.70 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 0.96 Pain Relevance 0.68
A statistically significant increase in TRPV1 immunoreactivity was observed in keratinocytes of patients with idiopathic small nerve fibre disease.
Positive_regulation (increase) of TRPV1 in nerve associated with disease
12) Confidence 0.70 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 0.89 Pain Relevance 0.07
To our knowledge, only one study has demonstrated increased TRPV1 immunoreactivity in a patient with painful neuropathy (postherpetic neuralgia).22 It is interesting to note that although the authors report a somewhat patchy increase of IENF with increased TRPV1, the immunofluorescence also seems clearly to show increased keratinocyte expression in the skin afflicted with neuropathy.
Positive_regulation (increased) of TRPV1 in keratinocyte associated with pain, neuropathic pain and postherpetic neuralgia
13) Confidence 0.70 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 1.13 Pain Relevance 0.72
Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons.
Positive_regulation (activating) of capsaicin receptor in sensory neurons associated with pain and qutenza
14) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14550768 Disease Relevance 0.53 Pain Relevance 0.71
Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons.
Positive_regulation (activating) of VR1 in sensory neurons associated with pain and qutenza
15) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14550768 Disease Relevance 0.47 Pain Relevance 0.70
A positive immunoreactivity of the VR1 was observed both on fibroblasts and on HaCaT cells by Western blotting analysis.
Positive_regulation (immunoreactivity) of VR1 in fibroblasts
16) Confidence 0.70 Published 2006 Journal Exp. Dermatol. Section Abstract Doc Link 16630076 Disease Relevance 0.08 Pain Relevance 0.21
Activation of vanilloid receptor 1 (VR1) by eugenol.
Positive_regulation (Activation) of VR1 associated with qutenza
17) Confidence 0.70 Published 2003 Journal J. Dent. Res. Section Title Doc Link 14514756 Disease Relevance 0.23 Pain Relevance 0.82
Activation of vanilloid receptor 1 (VR1) by eugenol.
Positive_regulation (Activation) of vanilloid receptor 1 associated with qutenza
18) Confidence 0.70 Published 2003 Journal J. Dent. Res. Section Title Doc Link 14514756 Disease Relevance 0.23 Pain Relevance 0.82
Moreover, there is also evidence that various inflammatory mediators such as adenosine triphosphate (ATP), bradykinin, nerve growth factor (NGF) or prostaglandin E(2) (PGE(2)) may indirectly lead to activation of the TRPV1 channel via activation of their respective receptors.
Positive_regulation (activation) of TRPV1 in nerve associated with adenocard, inflammatory mediators, nerve growth factor and bradykinin
19) Confidence 0.70 Published 2009 Journal Pulm Pharmacol Ther Section Abstract Doc Link 19141328 Disease Relevance 1.44 Pain Relevance 0.80
By contrast, TRPV1 appears to be upregulated during inflammatory conditions.
Spec (appears) Positive_regulation (upregulated) of TRPV1 associated with inflammation
20) Confidence 0.70 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15128291 Disease Relevance 0.64 Pain Relevance 0.42

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