INT93817

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.99
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Elk1) DNA binding (Elk1)
Anatomy Link Frequency
striatum 1
HSF 1
Elk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 14 98.86 Very High Very High Very High
Intracerebroventricular 4 94.40 High High
cytokine 35 93.68 High High
sodium channel 2 91.20 High High
Inflammation 41 91.12 High High
tetrodotoxin 2 89.28 High High
Inflammatory response 6 52.56 Quite High
Central nervous system 31 50.00 Quite Low
metalloproteinase 1 35.96 Quite Low
Hippocampus 10 25.52 Quite Low
Disease Link Frequency Relevance Heat
Cancer 78 99.52 Very High Very High Very High
INFLAMMATION 48 91.12 High High
Hepatocellular Cancer 36 86.84 High High
Apoptosis 42 80.48 Quite High
Metastasis 4 75.80 Quite High
Aging 39 68.84 Quite High
Natriuresis 2 67.60 Quite High
Disease 16 65.52 Quite High
Carcinoma 1 62.12 Quite High
Targeted Disruption 4 59.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of NK1R, the matrix _02 had a predominant participation driving 8 transcripts, which includes those involved in cancer (EYA1, Trail, HSF, and ELK-1), smooth-to-skeletal muscle trans-differentiation, and Z01, a tight-junction protein, expression (Table 3, [additional file 3]).
Gene_expression (expression) of ELK-1 in HSF associated with cancer
1) Confidence 0.22 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.32 Pain Relevance 0.05
In the coding region, putative regulatory factors include AHR/ARNT, USF, ELK1, HSF1, HSF2, ARP1, RFX1, GATA1, AP4, E2F, and ARP1.
Gene_expression (include) of ELK1
2) Confidence 0.17 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.13 Pain Relevance 0
These data indicate that cyclic AMP and mitogen-activated protein kinase signalling cascades are necessary for glutamate to induce cyclic AMP response-element binding protein and Elk-1 phosphorylation and Fos expression in the striatum.
Gene_expression (expression) of Elk-1 in striatum associated with glutamate
3) Confidence 0.15 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.43
MAPK can phosphorylate a variety of transcription factors, for example, ATF2, ELK1, CREB, MEF2C, CHOP/GADD153, and C/EBP?
Gene_expression (/) of ELK1
4) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.11 Pain Relevance 0.25
Activation of MAPK regulates the activities of a number of substrates including transcription factor p62TCF (Elk-1), c-myc, ATF2 and AP-1 components, c-Jun and c-fos [20].
Gene_expression (components) of Elk-1
5) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.42 Pain Relevance 0
The role of cyclic AMP and mitogen-activated protein kinase signalling cascades in glutamate-induced cyclic AMP response-element binding protein and Elk-1 phosphorylation and Fos expression was investigated using semiquantitative immunocytochemistry in vivo.
Gene_expression (expression) of Elk-1 associated with glutamate
6) Confidence 0.08 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.38

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox