INT9383

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2011
Negated 3
Speculated 5
Reported most in Body
Documents 98
Total Number 103
Disease Relevance 33.23
Pain Relevance 46.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
sensory neurons 9
nerves 6
sensory nerve 4
epithelial cells 4
neurons 4
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 951 100.00 Very High Very High Very High
Inflammation 485 100.00 Very High Very High Very High
Pain 479 100.00 Very High Very High Very High
substance P 141 100.00 Very High Very High Very High
Calcitonin gene-related peptide 129 100.00 Very High Very High Very High
dorsal root ganglion 129 100.00 Very High Very High Very High
cytokine 96 100.00 Very High Very High Very High
nociceptor 72 100.00 Very High Very High Very High
Inflammatory mediators 70 100.00 Very High Very High Very High
potassium channel 43 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 514 100.00 Very High Very High Very High
INFLAMMATION 489 100.00 Very High Very High Very High
Ganglion Cysts 220 100.00 Very High Very High Very High
Nociception 146 100.00 Very High Very High Very High
Cough 114 100.00 Very High Very High Very High
Injury 108 99.82 Very High Very High Very High
Dysmenorrhea 6 99.32 Very High Very High Very High
Headache 30 98.84 Very High Very High Very High
Neurogenic Inflammation 23 98.68 Very High Very High Very High
Heat Stress Disorders 22 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While TRPV1 has been localized in the epidermis, little is known about the physiological role of TRPV1 in the skin, especially in skin ageing.
Localization (localized) of TRPV1 in skin associated with aging
1) Confidence 0.81 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.17 Pain Relevance 0.10
The localization of TRPV1, 2, 3, and 4 in the laryngeal epithelium was investigated by immunohistochemistry.
Spec (investigated) Localization (localization) of TRPV1 in epithelium
2) Confidence 0.81 Published 2009 Journal Acta Otolaryngol. Section Body Doc Link 18629672 Disease Relevance 0 Pain Relevance 0
However, a description of VR1 localization in other cutaneous compartments in particular cutaneous nerve fibers is still lacking.
Localization (localization) of VR1 in nerve associated with vanilloid receptor subtype 1
3) Confidence 0.81 Published 2004 Journal Exp. Dermatol. Section Abstract Doc Link 14987252 Disease Relevance 0.29 Pain Relevance 0.73
Therefore, TRPV1 might modulate chlorhydropeptic secretion in the human stomach through more complex pathways than previously thought.
Localization (secretion) of TRPV1 in stomach
4) Confidence 0.81 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041554 Disease Relevance 0 Pain Relevance 0.14
While the corneal epithelium elicits such responses to a variety of challenges, it remains unknown whether TRPV1 mediates pro-inflammatory cytokine secretion.
Localization (secretion) of TRPV1 in corneal epithelium associated with inflammation and cytokine
5) Confidence 0.79 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17508360 Disease Relevance 0.27 Pain Relevance 0.37
It was found that the capacitation promoted the translocation of TRPV1 from the post-acrosomal to the apical region of sperm head.
Localization (translocation) of TRPV1 in head
6) Confidence 0.78 Published 2010 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 20219627 Disease Relevance 0 Pain Relevance 0.30
Microscopic evaluation assessed the presence and localization of OTR and TRPV1 throughout the menstrual cycle in both eutopic endometrial and endometriotic tissues of women with adenomyosis and compared them with normal endometrium.
Localization (localization) of TRPV1 in endometrium
7) Confidence 0.77 Published 2010 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 20096818 Disease Relevance 0.09 Pain Relevance 0
TRPV1-induced release of inflammatory mediators in the human esophagus
Localization (release) of TRPV1 in esophagus associated with inflammatory mediators
8) Confidence 0.77 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.28 Pain Relevance 0.64
Thus, consistent with presynaptic VR1 localization, CAP selectively activates a subset of ST axons to release glutamate that acts on non-NMDA receptors.
Localization (localization) of VR1 associated with glutamate and nmda receptor
9) Confidence 0.76 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223576 Disease Relevance 0.05 Pain Relevance 0.42
As an indicator of TRPV1 mediated ROS released into the supernatant, ROS metabolites 2,5-DHBA and 2,3-DHBA were trapped with salicylic acid [50] and the samples analyzed by high performance liquid chromatography with electrochemical detection (HPLC-ECD).
Localization (released) of TRPV1
10) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0 Pain Relevance 0.11
The cultures were then incubated overnight (37°C, 5% CO2) prior to removal of supernatant for Western blot analysis of ROS metabolites and immunocytochemical localization of TRPV1, COX-2, and TNF?.


Localization (localization) of TRPV1
11) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0 Pain Relevance 0.12
Mediators secreted by inflammatory cells activate sensory nerves via transient receptor potential vanilloid receptor 1 (TRPV1) and lead to the release of neuropeptides.
Localization (secreted) of TRPV1 in sensory nerves associated with inflammation and neuropeptide
12) Confidence 0.75 Published 2010 Journal Neuroimmunomodulation Section Abstract Doc Link 19923855 Disease Relevance 0.64 Pain Relevance 0.19
Double immunostaining for the regenerative neuronal marker Gap43 and the capsaicin receptor TRPV1 showed that the normal membrane-bound localisation of TRPV1 was absent in neurons with Ara C treatment, and as expected there was massive diminution of dividing non-neuronal cells.
Localization (localisation) of TRPV1 in neurons
13) Confidence 0.75 Published 2008 Journal J. Neurooncol. Section Body Doc Link 18414789 Disease Relevance 0.09 Pain Relevance 0
VR1 was mainly located in serous acinar and ductal cells, but not in mucous acinar cells.
Neg (not) Localization (located) of VR1 in acinar cells
14) Confidence 0.75 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20371865 Disease Relevance 0 Pain Relevance 0.25
We show that access to the pore of TRPV1 is gated by S6 in response to both capsaicin binding and increases in temperature, that the pore-forming S6 segments are helical structures and that two constrictions are present in the pore: one that impedes the access of large molecules and the other that hampers the access of smaller ions and constitutes an activation gate of these channels.
Localization (pore) of TRPV1 in pore associated with qutenza
15) Confidence 0.75 Published 2009 Journal Nat. Struct. Mol. Biol. Section Abstract Doc Link 19561608 Disease Relevance 0.17 Pain Relevance 0.23
We detected the presence of both TRPV1 and the dominant negative TRPV1b transcripts by real-time RT-PCR using primers and TaqMan probes specific either to TRPV1 or TRPV1b transcripts.
Localization (presence) of TRPV1
16) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0 Pain Relevance 0.50
The abundance of TRPV1 compared to TRPV1b was obvious as it was detected in other tissues [31].
Localization (abundance) of TRPV1b
17) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0 Pain Relevance 0.46
We detected the presence of both TRPV1 and the dominant negative TRPV1b transcripts by real-time RT-PCR using primers and TaqMan probes specific either to TRPV1 or TRPV1b transcripts.
Localization (presence) of TRPV1b
18) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0 Pain Relevance 0.50
The abundance of TRPV1 compared to TRPV1b was obvious as it was detected in other tissues [31].
Localization (abundance) of TRPV1
19) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0 Pain Relevance 0.46
Sensitization of TRPV1 during chronic pain is believed to contribute to the transduction of noxious signaling for normally innocuous stimuli and consequently the search for novel TRPV1 therapeutics is intense.
Localization (Sensitization) of TRPV1 associated with lasting pain
20) Confidence 0.75 Published 2006 Journal Semin. Cell Dev. Biol. Section Abstract Doc Link 17196854 Disease Relevance 0.37 Pain Relevance 0.43

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