INT93840

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2008
Negated 5
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.07
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNC1)
Anatomy Link Frequency
chest 1
TNNC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 27 97.84 Very High Very High Very High
agonist 10 95.92 Very High Very High Very High
beta blocker 10 93.36 High High
ischemia 11 92.48 High High
withdrawal 10 61.24 Quite High
Pain 10 55.64 Quite High
Analgesic 20 54.04 Quite High
Inflammation 10 45.28 Quite Low
addiction 10 32.56 Quite Low
Inflammatory marker 3 30.72 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 950 100.00 Very High Very High Very High
Acute Coronary Syndrome 11 99.84 Very High Very High Very High
Critical Illness 152 99.70 Very High Very High Very High
Emergencies 6 98.76 Very High Very High Very High
Death 66 98.56 Very High Very High Very High
Cv General 3 Under Development 14 97.84 Very High Very High Very High
Angina 18 97.52 Very High Very High Very High
Cv General 4 Under Development 7 96.80 Very High Very High Very High
Disease 10 96.60 Very High Very High Very High
Injury 26 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table 2 shows the morbidity and mortality outcomes of the patients with MI, elevated cTn only and no cTn elevation.
Neg (no) Gene_expression (elevation) of cTn associated with myocardial infarction
1) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.59 Pain Relevance 0
A total of 37 patients (35.9 per cent) had MI, 15 patients (14.6 per cent) had elevated cTn only (that is isolated cTn elevation), and 51 patients (49.5 per cent) had no cTn elevation.
Gene_expression (elevation) of cTn associated with myocardial infarction
2) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.58 Pain Relevance 0.03
We classified patients into three groups: MI (as defined above); elevated cTn only (one or more measurements of elevated cTn during ICU admission and all ECGs classified as having no ischemic changes supporting ESC/ACC criteria for MI); or no cTn elevation.


Neg (no) Gene_expression (elevation) of cTn associated with myocardial infarction
3) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.51 Pain Relevance 0
A total of 37 patients (35.9 per cent) had MI, 15 patients (14.6 per cent) had elevated cTn only (that is isolated cTn elevation), and 51 patients (49.5 per cent) had no cTn elevation.
Neg (no) Gene_expression (elevation) of cTn associated with myocardial infarction
4) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.60 Pain Relevance 0.03
Patients with elevated cTn had higher hospital mortality (26.7 per cent versus 2.0 per cent, p = 0.001) compared with patients without cTn elevation.
Gene_expression (elevation) of cTn
5) Confidence 0.50 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.56 Pain Relevance 0
Including MI identified by screening in the current study, we similarly found that patients with MI had significantly higher mortality in the ICU and hospital compared to patients without cTn elevation.
Gene_expression (elevation) of cTn associated with myocardial infarction
6) Confidence 0.50 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 1.14 Pain Relevance 0.11
We classified patients into three groups: MI (as defined above); elevated cTn only (one or more measurements of elevated cTn during ICU admission and all ECGs classified as having no ischemic changes supporting ESC/ACC criteria for MI); or no cTn elevation.


Neg (no) Gene_expression (elevation) of cTn associated with myocardial infarction
7) Confidence 0.50 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.70 Pain Relevance 0
Table 2 shows the morbidity and mortality outcomes of the patients with MI, elevated cTn only and no cTn elevation.
Neg (no) Gene_expression (elevation) of cTn associated with myocardial infarction
8) Confidence 0.50 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.60 Pain Relevance 0
Furthermore, the safety of these medications in critically ill patients with cTn elevation and ECG changes should be further explored since certain agents used widely in the ICU (such as beta-agonists) may be incompatible with cardiac medications (such as beta-blockers).
Gene_expression (elevation) of cTn associated with beta blocker, critical illness and agonist
9) Confidence 0.50 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.69 Pain Relevance 0.09
Whether these agents improve the outcome of patients with cTn elevation alone in the absence of ECG changes is unknown.
Gene_expression (elevation) of cTn
10) Confidence 0.50 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.68 Pain Relevance 0.08
Cardiac troponins (cTn) are frequently assessed in patients presenting at the emergency department (ED) with chest pain and various diseases in which myocardial injury may be involved.
Gene_expression (assessed) of cTn in chest associated with angina, emergencies, injury and disease
11) Confidence 0.43 Published 2008 Journal Am J Emerg Med Section Abstract Doc Link 18358946 Disease Relevance 0.59 Pain Relevance 0.10
[Experiences with determination of cardiac Troponin-I and CK-MB serum levels in acute coronary syndrome].
Gene_expression (levels) of cardiac Troponin associated with acute coronary syndrome
12) Confidence 0.02 Published 2001 Journal Orv Hetil Section Title Doc Link 11209507 Disease Relevance 0.51 Pain Relevance 0.14
Kaplan-Meier survival analysis showed that cTn-I elevation was not an important correlate of overall cardiac events (log-rank: 1.66, p=0.19).
Gene_expression (elevation) of cTn-I
13) Confidence 0.01 Published 2006 Journal Angiology Section Abstract Doc Link 16518523 Disease Relevance 0.54 Pain Relevance 0.36
During the prospective follow-up period for 21 +/-7.5 months, the incidence of major cardiac events including recurrent angina, acute myocardial infarction, death, and revascularization were not different in patients with and without cTn-I elevation.
Gene_expression (elevation) of cTn-I associated with angina, death and myocardial infarction
14) Confidence 0.01 Published 2006 Journal Angiology Section Abstract Doc Link 16518523 Disease Relevance 0.58 Pain Relevance 0.38
A number of cardiac biomarkers are now commonly used in the ICU; in particular, cTn, CRP, and CK-MB. cTn are known to be increased in intensive care patients, and are not confined to patients with cardiac injury or acute coronary syndromes [106-109].
Gene_expression (used) of cTn associated with acute coronary syndrome and injury
15) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.20 Pain Relevance 0.21

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