INT93843

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgir) plasma membrane (Ptgir) signal transducer activity (Ptgir)
Anatomy Link Frequency
spinal cord 2
Ptgir (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.78 Very High Very High Very High
Inflammation 4 99.40 Very High Very High Very High
Pain 2 99.14 Very High Very High Very High
cINOD 3 95.48 Very High Very High Very High
Hyperalgesia 1 94.88 High High
agonist 1 93.20 High High
intrathecal 1 91.88 High High
COX-2 inhibitor 2 86.80 High High
IPN 1 79.68 Quite High
antagonist 1 30.24 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 5 99.96 Very High Very High Very High
INFLAMMATION 3 99.40 Very High Very High Very High
Pain 2 99.14 Very High Very High Very High
Hyperalgesia 1 94.88 High High
Inflammatory Pain 1 79.68 Quite High
Nociception 1 75.00 Quite High
Pressure And Volume Under Development 1 74.88 Quite High
Vasculitis 1 58.88 Quite High
Syndrome 1 41.28 Quite Low
Increased Venous Pressure Under Development 1 34.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that PGI2 is involved in pain transmission at the spinal cord following expression of IP receptor mRNA induced by peripheral inflammation.
Positive_regulation (induced) of Gene_expression (expression) of IP receptor mRNA in spinal cord associated with pain, inflammation and spinal cord
1) Confidence 0.69 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924902 Disease Relevance 0.67 Pain Relevance 0.62
Although deletion of the prostacyclin receptor (the IP) accelerates atherogenesis in the mouse, retention of one copy of the IP is atheroprotective.
Positive_regulation (accelerates) of Gene_expression (deletion) of prostacyclin receptor associated with atherosclerosis
2) Confidence 0.20 Published 2000 Journal Ann. Med. Section Abstract Doc Link 11209977 Disease Relevance 0.47 Pain Relevance 0.23

General Comments

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