INT93844

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 12.12
Pain Relevance 7.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgir) plasma membrane (Ptgir) signal transducer activity (Ptgir)
Anatomy Link Frequency
spinal cord 2
fat 1
platelet 1
dorsal root ganglion 1
Ptgir (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
bradykinin 10 99.96 Very High Very High Very High
COX-2 inhibitor 100 99.92 Very High Very High Very High
Spinal cord 4 99.78 Very High Very High Very High
dorsal root ganglion 54 99.70 Very High Very High Very High
Pain 31 99.20 Very High Very High Very High
Inflammation 104 99.08 Very High Very High Very High
tail-flick 1 97.52 Very High Very High Very High
Analgesic 18 97.36 Very High Very High Very High
intrathecal 2 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 114 99.70 Very High Very High Very High
Pain 32 99.20 Very High Very High Very High
Atherosclerosis 10 99.12 Very High Very High Very High
INFLAMMATION 125 99.08 Very High Very High Very High
Targeted Disruption 68 99.04 Very High Very High Very High
Alzheimer's Dementia 1 98.88 Very High Very High Very High
Cancer 160 98.84 Very High Very High Very High
Nociception 24 97.44 Very High Very High Very High
Fever 4 97.04 Very High Very High Very High
Coronary Artery Disease 16 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that PGI2 is involved in pain transmission at the spinal cord following expression of IP receptor mRNA induced by peripheral inflammation.
Gene_expression (expression) of IP receptor mRNA in spinal cord associated with pain, inflammation and spinal cord
1) Confidence 0.77 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924902 Disease Relevance 0.67 Pain Relevance 0.62
Intraplantar injection of carrageenan markedly induced the expression of prostacyclin receptor (IP receptor) mRNA with the maximum at 6 h, coincidently induction of the inducible form of cyclooxygenase (COX-2), although IP receptor mRNA was weakly expressed in the spinal cord of naive mice.
Gene_expression (expressed) of IP receptor mRNA in spinal cord associated with spinal cord
2) Confidence 0.77 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924902 Disease Relevance 0.59 Pain Relevance 0.61
By studying the structural similarity of analgesic imidazolines and 2-phenylnitronyl nitroxides, 20 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines (2a-t) were newly synthesized as selective antagonists of prostacyclin receptor (IP receptor).
Gene_expression (synthesized) of prostacyclin receptor associated with antagonist and analgesic
3) Confidence 0.60 Published 2008 Journal Eur J Med Chem Section Abstract Doc Link 17804120 Disease Relevance 0.35 Pain Relevance 0.36
Sensitization of TRPV1 by IP receptors
Gene_expression (receptors) of IP
4) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 1.00 Pain Relevance 0.81
Although deletion of the prostacyclin receptor (the IP) accelerates atherogenesis in the mouse, retention of one copy of the IP is atheroprotective.
Gene_expression (deletion) of prostacyclin receptor associated with atherosclerosis
5) Confidence 0.26 Published 2000 Journal Ann. Med. Section Abstract Doc Link 11209977 Disease Relevance 0.47 Pain Relevance 0.23
Primary sensory neurons in dorsal root ganglion (DRG) are known to express mRNAs encoding several prostanoid receptor subtypes, IP, EP1, EP3 and EP4 [6,7].
Gene_expression (express) of IP in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
6) Confidence 0.24 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 1.22 Pain Relevance 1.18
In group of mice fed with high fat diet, Cox1, Cox2 genes as well prostaglandin synthase and prostacyclin receptor expression were activated, what may lead to synthesis of pro-inflammatory prostanoids [35].
Gene_expression (expression) of prostacyclin receptor in fat associated with inflammation
7) Confidence 0.19 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.37 Pain Relevance 0.08
Tumor growth, with and without provision of a classical cyclo-oxygenase inhibitor (indomethacin), was related to tumor content of COX-1/COX-2 protein as well as to EP1-EP4 and prostacyclin receptor expression.
Gene_expression (expression) of prostacyclin receptor associated with cancer
8) Confidence 0.19 Published 2005 Journal Int. J. Oncol. Section Abstract Doc Link 16142306 Disease Relevance 1.18 Pain Relevance 0.34
However, in the LPS-pretreated mice, not only PGI2 but also other PGs produced by COX-2 may be involved in pain induction.
Gene_expression (produced) of PGI2 associated with pain
9) Confidence 0.11 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11338374 Disease Relevance 0.90 Pain Relevance 0.63
PGE2 and PGI2 promote bradykinin-induced pain (Katori et al. 1986).
Gene_expression (promote) of PGI2 associated with pain and bradykinin
10) Confidence 0.06 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.96 Pain Relevance 0.39
Seminal experimental studies, including those with knockout mice, have demonstrated that the COX-2 isoform produces vascular PGI2, which is a pivotal biologic vasodilator and an inhibitor of platelet aggregation.
Gene_expression (produces) of PGI2 in platelet associated with targeted disruption
11) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.71 Pain Relevance 0.19
It has now been unequivocally demonstrated, however, that selective COX-2 inhibitors also decrease vascular prostacyclin (PGI2) production and may affect the homeostatic balance, leading to a prothrombotic state [5].
Gene_expression (production) of PGI2 associated with cox-2 inhibitor
12) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.75 Pain Relevance 0.82
By decreasing vasodilatory and antiplatelet aggregatory PGI2 production, COX-2 inhibitors may tip the balance in favor of prothrombotic eicosanoids (thromboxane A2 [TXA2]) and may lead to increased cardiovascular thrombotic events [6].


Gene_expression (production) of PGI2 associated with cox-2 inhibitor
13) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.60 Pain Relevance 0.58
Selective COX-2 inhibitors have no effect on TXA2 production but, by decreasing PGI2 production, they may affect the homeostatic balance between prothrombotic TXA2 and antithrombotic PGI2, and may lead to an increase in thrombotic cardiovascular events [20,21].
Gene_expression (production) of PGI2 associated with cox-2 inhibitor
14) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.70 Pain Relevance 0.18
However, septic insult increases production of superoxide that reacts with nitric oxide to form peroxynitrite that nitrates and inactivates endothelial PGI2 synthase, which can then no longer synthesize PGI2.
Neg (no) Gene_expression (synthesize) of PGI2
15) Confidence 0.02 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.27 Pain Relevance 0.08
Separate studies suggest that other products of the COX pathway, thromboxane A2 and PGI2 also promote angiogenesis [72,75,109,110].
Gene_expression (products) of PGI2
16) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.33 Pain Relevance 0.10
Although our data strongly implicate the ON-bipolar circuit in the light-evoked expression of Fos in M1 ipRGCs, the structural basis for this unusual circuit is currently unknown and the pathway could be either direct or indirect.
Gene_expression (expression) of ipRGCs
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.20 Pain Relevance 0
This seems reasonable since both the light-evoked extrinsic input and the intrinsic photo response both produce sustained depolarizations of the ipRGCs [4], [10].
Gene_expression (produce) of ipRGCs
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.15 Pain Relevance 0.06
Both COX enzymes catalyze the conversion of arachidonic acid to PGG2 and subsequently to PGH2, which acts as a substrate for multiple isomerases that are individually responsible for the generation of eicosanoid products, including PGE2, prostacyclin (PGI2), and thromboxane A2 (Figure 1).
Gene_expression (products) of prostacyclin
19) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.70 Pain Relevance 0.39

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