INT9385

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Context Info
Confidence 0.81
First Reported 1986
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 74
Total Number 81
Disease Relevance 31.67
Pain Relevance 10.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA)
cytoplasm (LDHA)
Anatomy Link Frequency
neutrophils 6
HeLa 3
chondrocytes 1
plasma 1
macrophages 1
LDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 47 99.58 Very High Very High Very High
diclofenac 80 99.32 Very High Very High Very High
Dopamine 14 98.68 Very High Very High Very High
abdominal pain 3 98.32 Very High Very High Very High
Glutamate receptor 4 97.32 Very High Very High Very High
local anesthetic 10 97.04 Very High Very High Very High
cytokine 416 96.40 Very High Very High Very High
Analgesic 21 95.92 Very High Very High Very High
methadone 14 94.96 High High
Morphine 57 94.40 High High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 5 100.00 Very High Very High Very High
Necrosis 169 99.96 Very High Very High Very High
Death 382 99.54 Very High Very High Very High
Aids-related Complex 147 99.36 Very High Very High Very High
Loss Of Sense Of Smell 30 99.36 Very High Very High Very High
Infection 248 99.16 Very High Very High Very High
Liver Cancer 1 99.14 Very High Very High Very High
Apoptosis 633 98.96 Very High Very High Very High
Syndrome 5 98.84 Very High Very High Very High
Parkinson's Disease 24 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 60 minutes of exposure, ioxaglate at the higher concentration (150 mg iodine per milliliter) significantly increased the LDH signal (ie, the percentage of LDH released), to 20%.
Localization (released) of LDH
1) Confidence 0.81 Published 2001 Journal Acad Radiol Section Body Doc Link 11227644 Disease Relevance 0.21 Pain Relevance 0
METHODS: The concentration- and time-dependent effects of lidocaine on retinoic acid-differentiated human neuroblastoma SH-SY5Y cells were quantified by trypan blue staining, the release of lactate dehydrogenase, immunocytochemistry and flow cytometry.
Localization (release) of lactate dehydrogenase in SH-SY5Y
2) Confidence 0.81 Published 2002 Journal Eur J Anaesthesiol Section Body Doc Link 12200945 Disease Relevance 0 Pain Relevance 0
RESULTS: The local anaesthetic caused a significant increase in the number of cells staining positive for trypan blue, a significant increase of LDH release into the incubation medium, and a significant increase of 7AAD and annexin V binding.
Localization (release) of LDH
3) Confidence 0.81 Published 2002 Journal Eur J Anaesthesiol Section Body Doc Link 12200945 Disease Relevance 0 Pain Relevance 0
Biochemical markers of viability (glucose utilization (CGU) and lactate dehydrogenase (LDH) release), vascular resistance (VR), venous arsenic flux, and morphological parameters (light and electron microscopy) were evaluated.
Localization (release) of LDH
4) Confidence 0.80 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1412463 Disease Relevance 0.29 Pain Relevance 0.08
Biochemical markers of viability (glucose utilization (CGU) and lactate dehydrogenase (LDH) release), vascular resistance (VR), venous arsenic flux, and morphological parameters (light and electron microscopy) were evaluated.
Localization (release) of lactate dehydrogenase
5) Confidence 0.80 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1412463 Disease Relevance 0.29 Pain Relevance 0.08
It was found that no fiber length or concentration induced significant cellular membrane damage as assessed by cytosolic LDH release into the cellular supernatant although a concentration-dependent trend was apparent (Figure 1).
Localization (release) of cytosolic LDH
6) Confidence 0.80 Published 2006 Journal Part Fibre Toxicol Section Body Doc Link PMC1459188 Disease Relevance 0 Pain Relevance 0
The FDVE-cysteine conjugates S-(1,1-difluoro-2-fluoromethoxy-2-(trifluoromethyl) ethyl)-L-cysteine (DFEC) and (Z)-S-(1-fluoro-2-fluoromethoxy-2-(trifluoromethyl) vinyl)-L-cysteine ((Z)-FFVC) caused significant differences in LDH release and MTT reduction only at 2.7 mM; (Z)-FFVC was slightly more cytotoxic.
Localization (release) of LDH
7) Confidence 0.79 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613716 Disease Relevance 0.12 Pain Relevance 0.05
Cytotoxicity was determined by lactate dehydrogenase (LDH) release, total LDH, and the ability of viable cells to reduce a tetrazolium-based compound (MTT).
Localization (release) of LDH
8) Confidence 0.79 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613716 Disease Relevance 0.15 Pain Relevance 0.07
Both S-(1,1-difluoro-2-fluoromethoxy-2-(trifluoromethyl) ethyl)-L-cysteine sulfoxide (DFEC-SO) and (Z)-N-acetyl-S-(1-fluoro-2-fluoromethoxy-2-(trifluoromethyl) vinyl)-L-cysteine sulfoxide ((Z)-N-Ac-FFVC-SO) caused slightly greater changes in LDH release or total LDH than the corresponding equimolar DFEC and (Z)-N-acetyl-S-(1-fluoro-2-fluoromethoxy-2-(trifluoromethyl) vinyl)-L-cysteine ((Z)-N-Ac-FFVC) conjugates.
Localization (release) of LDH
9) Confidence 0.79 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613716 Disease Relevance 0.05 Pain Relevance 0
No increase in LDH release was observed with either FDVE-GSH conjugate.
Localization (release) of LDH
10) Confidence 0.79 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613716 Disease Relevance 0.14 Pain Relevance 0.06
Cytotoxicity was determined by lactate dehydrogenase (LDH) release, total LDH, and the ability of viable cells to reduce a tetrazolium-based compound (MTT).
Localization (release) of LDH
11) Confidence 0.79 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613716 Disease Relevance 0.15 Pain Relevance 0.07
Both S-(1,1-difluoro-2-fluoromethoxy-2-(trifluoromethyl) ethyl)-L-cysteine sulfoxide (DFEC-SO) and (Z)-N-acetyl-S-(1-fluoro-2-fluoromethoxy-2-(trifluoromethyl) vinyl)-L-cysteine sulfoxide ((Z)-N-Ac-FFVC-SO) caused slightly greater changes in LDH release or total LDH than the corresponding equimolar DFEC and (Z)-N-acetyl-S-(1-fluoro-2-fluoromethoxy-2-(trifluoromethyl) vinyl)-L-cysteine ((Z)-N-Ac-FFVC) conjugates.
Localization (release) of LDH
12) Confidence 0.79 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613716 Disease Relevance 0.05 Pain Relevance 0
Rhabdomyolysis is a clinical and biochemical syndrome occurring when skeletal muscle cells erupt and result in release of creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and myoglobin into the interstitial space and plasma.
Localization (release) of LDH in skeletal muscle cells associated with disorders of creatine metabolism, syndrome and rhabdomyolysis
13) Confidence 0.72 Published 2007 Journal Hum Exp Toxicol Section Abstract Doc Link 17884958 Disease Relevance 1.15 Pain Relevance 0.05
In unexplained abdominal pain with insufficiently specific results of physical examination combined with a rapid rise of the LDH and sometimes of the serum creatinine, a kidney infarction should be considered in the differential diagnosis.
Localization (rise) of LDH in kidney associated with abdominal pain and infarction
14) Confidence 0.71 Published 1998 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 10028329 Disease Relevance 0.45 Pain Relevance 0.18
Mild decreases in CGU were noted with the higher concentrations of L, while generally increased responses in LDH release and VR were seen.
Localization (release) of LDH
15) Confidence 0.71 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1412463 Disease Relevance 0.43 Pain Relevance 0.06
Further, the production of albumin, lactate dehydrogenase release, lactate release, urea production, and glucose consumption were measured.
Localization (release) of lactate dehydrogenase
16) Confidence 0.63 Published 2010 Journal Tissue Eng Part A Section Abstract Doc Link 19778170 Disease Relevance 0.31 Pain Relevance 1.11
Cytotoxicity was assessed by monitoring cytosolic lactate dehydrogenase release and loss of function as indicated by a decrease in zymosan-stimulated chemiluminescence.


Localization (release) of lactate
17) Confidence 0.61 Published 2006 Journal Part Fibre Toxicol Section Abstract Doc Link PMC1459188 Disease Relevance 0.09 Pain Relevance 0
Cytosolic free calcium rose immediately to almost three times baseline and was associated with lactate dehydrogenase release at 24 hr, indicating significant cell injury.
Localization (release) of lactate dehydrogenase associated with injury
18) Confidence 0.60 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9579412 Disease Relevance 0.49 Pain Relevance 0.13
Blocking the N-methyl-D-aspartate glutamate receptor complex with dizocilipine maleate attenuated calcium increases by 45% in injured neurons and blocked a significant part (50%) of the lactate dehydrogenase release.
Localization (release) of lactate dehydrogenase in neurons associated with glutamate receptor
19) Confidence 0.60 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9579412 Disease Relevance 0.48 Pain Relevance 0.21
Further, the production of albumin, lactate dehydrogenase release, lactate release, urea production, and glucose consumption were measured.
Localization (release) of lactate dehydrogenase
20) Confidence 0.55 Published 2010 Journal Tissue Eng Part A Section Abstract Doc Link 19778170 Disease Relevance 0.32 Pain Relevance 1.11

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