INT93854

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Context Info
Confidence 0.19
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
lung 2
afferent neurons 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 99.10 Very High Very High Very High
ketamine 1 98.70 Very High Very High Very High
COX2 3 98.64 Very High Very High Very High
substance P 8 98.60 Very High Very High Very High
dorsal root ganglion 7 93.00 High High
COX-2 inhibitor 1 49.28 Quite Low
Inflammation 3 25.56 Quite Low
Hyperalgesia 1 25.04 Quite Low
Pain 2 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 92.52 High High
Glioma 2 84.16 Quite High
Pressure And Volume Under Development 1 25.00 Low Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE AND DESIGN: The purpose of the present study was to evaluate the effect of urethane, pentobarbital sodium and ketamine-xylazine anesthesia upon constitutive and inducible cyclooxygenase (COX-1; COX-2) and nitric oxide synthase (eNOS; iNOS) mRNA levels in the lung.
Positive_regulation (inducible) of Transcription (levels) of cyclooxygenase in lung associated with anesthesia and ketamine
1) Confidence 0.19 Published 2000 Journal Inflamm. Res. Section Abstract Doc Link 11211925 Disease Relevance 0 Pain Relevance 0.15
Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms.
Positive_regulation (increase) of Transcription (levels) of cyclooxygenase in afferent neurons associated with cox2 and substance p
2) Confidence 0.07 Published 2002 Journal Neuropharmacology Section Title Doc Link 12384172 Disease Relevance 0.38 Pain Relevance 0.52
By immunoblotting and reverse-transcription polymerase chain reaction, we showed that gamma-mangostin concentration-dependently inhibited lipopolysaccharide (LPS)-induced expression of COX-2 protein and its mRNA, but not those of constitutive COX-1 cyclooxygenase.
Positive_regulation (-induced) of Transcription (expression) of COX-1 cyclooxygenase
3) Confidence 0.07 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.16 Pain Relevance 0

General Comments

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