INT9387

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 3.99
Pain Relevance 8.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 4
striatum 2
adrenal glands 2
midbrain 2
hypophysis 2
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 60 100.00 Very High Very High Very High
headache 16 100.00 Very High Very High Very High
midbrain 9 100.00 Very High Very High Very High
tail-flick 1 100.00 Very High Very High Very High
alcohol 14 99.72 Very High Very High Very High
Pain 23 99.34 Very High Very High Very High
Pyramidal cell 2 98.68 Very High Very High Very High
Deafferentation 1 98.20 Very High Very High Very High
medulla 6 98.08 Very High Very High Very High
Hippocampus 4 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paroxysmal Hemicrania 8 100.00 Very High Very High Very High
Alcohol Addiction 2 99.98 Very High Very High Very High
Insulin Coma 2 99.68 Very High Very High Very High
Stress 23 99.48 Very High Very High Very High
Urological Neuroanatomy 2 99.48 Very High Very High Very High
Cluster Headache 12 95.60 Very High Very High Very High
Convulsion 6 91.28 High High
Pain 3 89.60 High High
Headache 9 70.92 Quite High
Body Weight 1 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is established that carboxypeptidase H activity increases as affected by various stress factors in the rat brain departments.
Positive_regulation (increases) of carboxypeptidase H in brain associated with stress
1) Confidence 0.70 Published 1992 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 1413117 Disease Relevance 0.35 Pain Relevance 0.09
Reflex splanchnic nerve stimulation increases levels of carboxypeptidase E mRNA and enzymatic activity in the rat adrenal medulla.
Positive_regulation (increases) of carboxypeptidase E in adrenal medulla associated with medulla and enkephalin
2) Confidence 0.69 Published 1990 Journal J. Neurochem. Section Title Doc Link 2370548 Disease Relevance 0.06 Pain Relevance 0.60
Emotional-painful stress and alcohol intoxication activated carboxypeptidase H in the rat pituitary gland.
Positive_regulation (activated) of carboxypeptidase H in pituitary gland associated with stress, pain and alcohol
3) Confidence 0.68 Published 1994 Journal Vopr. Med. Khim. Section Abstract Doc Link 8122415 Disease Relevance 0.52 Pain Relevance 0.44
In blood serum carboxypeptidase H-like activity was increased after the single emotional-painful stress, while it decreased in chronic stress.
Positive_regulation (increased) of carboxypeptidase H-like in blood associated with stress and pain
4) Confidence 0.68 Published 1994 Journal Vopr. Med. Khim. Section Abstract Doc Link 8122415 Disease Relevance 0.62 Pain Relevance 0.45
Evidence is discussed which illustrates how CPH can be inhibited and activated.
Positive_regulation (activated) of CPH
5) Confidence 0.67 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 3135937 Disease Relevance 0 Pain Relevance 0.17
The carboxypeptidase H activity was elevated in midbrain, striatum, hypophysis and adrenal glands, while the ACE activity was increased in hypophysis and striatum.
Positive_regulation (elevated) of carboxypeptidase H in striatum associated with midbrain
6) Confidence 0.60 Published 1991 Journal Vopr. Med. Khim. Section Abstract Doc Link 1661050 Disease Relevance 0 Pain Relevance 0.27
With ethanol consumption, activity of carboxypeptidase H was increased in all the brain regions of rats with chronic emotional-painful stress.
Positive_regulation (increased) of carboxypeptidase H in brain associated with stress and pain
7) Confidence 0.56 Published 1993 Journal Vopr. Med. Khim. Section Abstract Doc Link 8511888 Disease Relevance 0.17 Pain Relevance 0.25
The highest levels of CPE mRNA were found to be present in the pyramidal cells of the hippocampus, the pituitary anterior and intermediate lobes, the ependymal cells of the lateral ventricle, the endopiriform nucleus, the basolateral amygdala, the supraoptic nucleus, and the paraventricular nucleus.
Positive_regulation (levels) of CPE mRNA in lateral ventricle associated with pyramidal cell, hippocampus and amygdala
8) Confidence 0.50 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0 Pain Relevance 0.36
CPE mRNA is also influenced by the insulin shock, with levels increasing to 155% of the control level after 6 h and 170% after 2 days.
Positive_regulation (influenced) of CPE associated with insulin coma
9) Confidence 0.50 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2370548 Disease Relevance 0.10 Pain Relevance 0.54
If the aforementioned grouping of CPH is correct, then the CPH subdivision with mechanical precipitation of attacks should also be closely akin to cluster headache.
Positive_regulation (grouping) of CPH associated with cluster headache
10) Confidence 0.49 Published 1991 Journal Acta Neurol (Napoli) Section Abstract Doc Link 1805550 Disease Relevance 0.67 Pain Relevance 0.73
The localized sweating increase in the forehead during attacks of CPH may possibly be a result of direct sympathetic stimulation.
Positive_regulation (increase) of CPH in sympathetic associated with headache
11) Confidence 0.49 Published 1983 Journal Cephalalgia Section Abstract Doc Link 6627383 Disease Relevance 0.72 Pain Relevance 0.65
The percentage of cultured astrocytes expressing high levels of CPE mRNA was 42% for frontal cortex astrocytes and 23% for cerebellar astrocytes.
Positive_regulation (levels) of CPE mRNA in astrocytes associated with urological neuroanatomy
12) Confidence 0.46 Published 1992 Journal Brain Res. Section Abstract Doc Link 1540832 Disease Relevance 0.17 Pain Relevance 0.08
CONCLUSIONS: Attack duration is the clinical feature that best distinguishes CPH from other trigeminal autonomic cephalgias.
Positive_regulation (distinguishes) of CPH in autonomic
13) Confidence 0.43 Published 2002 Journal Headache Section Body Doc Link 12390632 Disease Relevance 0.06 Pain Relevance 0
The carboxypeptidase H activity was elevated in midbrain, striatum, hypophysis and adrenal glands, while the ACE activity was increased in hypophysis and striatum.
Positive_regulation (increased) of carboxypeptidase H in striatum associated with midbrain
14) Confidence 0.41 Published 1991 Journal Vopr. Med. Khim. Section Abstract Doc Link 1661050 Disease Relevance 0 Pain Relevance 0.27
RESULTS: Most of the study patients reported that their CPH was unchanged.
Neg (unchanged) Positive_regulation (unchanged) of CPH
15) Confidence 0.40 Published 2008 Journal Acta Med Croatica Section Body Doc Link 18710079 Disease Relevance 0.07 Pain Relevance 0
An increase in the activity of the processing enzyme carboxypeptidase E was observed at day 15, which may contribute to the developmental fall in the adrenal proenkephalin to free ME ratio.
Positive_regulation (increase) of carboxypeptidase E associated with enkephalin
16) Confidence 0.38 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8432002 Disease Relevance 0 Pain Relevance 0.86
While these results demonstrate the presence of the DAT: CPE protein complex in rat striatal tissue, it does not clarify whether the DAT: CPE protein complex is formed through a direct interaction or is mediated indirectly by an accessory binding protein.
Spec (whether) Positive_regulation (mediated) of CPE
17) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
The present finding highlighted the importance of CPE in trafficking and metabolic processing of DAT.
Positive_regulation (importance) of CPE
18) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.12
The central enzymatic stability of des-enkephalin-gamma-endorphin and its synthetic analogs [cycloN alpha 6, C delta 11]beta-endorphin-[6-17] and [Pro7, Lys(Ac)9]-beta-endorphin[6-17] was studied in vitro using a newly developed, regionally dissected rat brain slice, time course incubation procedure.
Positive_regulation (stability) of des-enkephalin-gamma-endorphin in brain associated with enkephalin
19) Confidence 0.24 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2140132 Disease Relevance 0 Pain Relevance 0.14
The carboxypeptidase H activity was elevated in midbrain, striatum, hypophysis and adrenal glands, while the ACE activity was increased in hypophysis and striatum.
Positive_regulation (elevated) of carboxypeptidase H in hypophysis associated with midbrain
20) Confidence 0.21 Published 1991 Journal Vopr. Med. Khim. Section Abstract Doc Link 1661050 Disease Relevance 0 Pain Relevance 0.27

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