INT93886

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2011
Negated 4
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 15.78
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
stromal cells 4
epithelium 2
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 4 100.00 Very High Very High Very High
Gabapentin 3 96.58 Very High Very High Very High
carbamazepine 12 96.14 Very High Very High Very High
withdrawal 4 95.60 Very High Very High Very High
tolerance 2 95.60 Very High Very High Very High
Pain 8 94.88 High High
endometriosis 13 92.00 High High
pain pelvic 6 85.96 High High
Dismenorea 3 85.36 High High
agonist 6 83.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 524 100.00 Very High Very High Very High
Breast Cancer 521 100.00 Very High Very High Very High
Stress 12 100.00 Very High Very High Very High
Endometriosis (extended) 11 100.00 Very High Very High Very High
Fibrosis 5 100.00 Very High Very High Very High
Hyperplasia 4 100.00 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 38 99.64 Very High Very High Very High
Carcinoma 39 98.88 Very High Very High Very High
Endometriosis 19 98.80 Very High Very High Very High
Inflammatory Breast Neoplasms 126 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tamoxifen induced endometrial polyps, cystic hyperplasia, stromal fibrosis, and PR expression but not Ki-67 expression.
Positive_regulation (induced) of Gene_expression (expression) of PR associated with fibrosis, endometriosis (extended) and hyperplasia
1) Confidence 0.52 Published 2001 Journal Toxicol Pathol Section Abstract Doc Link 11215689 Disease Relevance 0.58 Pain Relevance 0.14
We also observed that 8 d of MPA increased PR expression.
Positive_regulation (increased) of Gene_expression (expression) of PR
2) Confidence 0.52 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12050207 Disease Relevance 0.34 Pain Relevance 0.16
The inability of endometriotic stromal cells to produce progesterone-induced paracrine factors that stimulate 17beta-HSD-2 may be due to the lack of PR-B and very low levels of progesterone receptor A (PR-A) observed in vivo in endometriotic tissue.
Positive_regulation (due) of Neg (lack) Gene_expression (lack) of progesterone receptor in stromal cells associated with endometriosis
3) Confidence 0.49 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 0.92 Pain Relevance 0.41
PR expression was significantly higher in secondary post-surgical IC (p = 0.04).
Positive_regulation (higher) of Gene_expression (expression) of PR associated with carcinoma
4) Confidence 0.39 Published 2003 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 12725414 Disease Relevance 1.57 Pain Relevance 0.16
Overexpression of the PR indicates that the ER pathway is intact, even if the tumor is reported as ER-negative.51,52 When biochemical ligand-binding assays indicate concentrations of 10 fmol/mg cytosol protein or more, the tumors are generally considered ER-positive and PR-positive for clinical purposes.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PR associated with cancer
5) Confidence 0.38 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.83 Pain Relevance 0
Cotransfection of endometrial stromal cells with PR enhanced the effects mediated by endogenous PR.
Positive_regulation (Cotransfection) of Gene_expression (Cotransfection) of PR in stromal cells
6) Confidence 0.37 Published 2002 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12050207 Disease Relevance 0.33 Pain Relevance 0.21
/PR negative breast cancer.50 Further studies will be required to establish the value of ER?
Positive_regulation (required) of Neg (negative) Gene_expression (negative) of PR associated with breast cancer
7) Confidence 0.27 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.84 Pain Relevance 0
In many breast tumor cell lines—and in normal tissues containing ER, such as the endometrium and brain—PR expression is induced by estrogen.51,52 It is still not known whether ER regulates PR in normal human mammary epithelium in precisely the same subpopulation of ductal and lobular luminal cells, although this assumption is considered to be likely.
Positive_regulation (induced) of Gene_expression (expression) of PR in epithelium associated with breast cancer
8) Confidence 0.25 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.84 Pain Relevance 0
Although the time to progression was similar for IBC tumors with either low or high LI, those patients whose tumors had a lower LI and were PgR positive survived longer (31 months) than did those whose tumors were PgR negative with a high LI (18 months).
Positive_regulation (tumors) of Neg (negative) Gene_expression (negative) of PgR associated with inflammatory breast neoplasms and cancer
9) Confidence 0.25 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 2.64 Pain Relevance 0
Overexpression of the PR serves as a functional assay because it indicates that the ER pathway is intact, even if the tumor is reported as ER-negative.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PR associated with cancer
10) Confidence 0.16 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 0.50 Pain Relevance 0
Although all tumors were ER positive, levels of expression varied between patients and half of the tumors showed no PR expression.
Neg (no) Positive_regulation (showed) of Neg (no) Gene_expression (expression) of PR associated with cancer
11) Confidence 0.15 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 1.70 Pain Relevance 0
1 suppresses expression of progesterone receptor (PR) suggesting that TGF?
Positive_regulation (suggesting) of Gene_expression (expression) of PR
12) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.23 Pain Relevance 0.14
1 suppresses expression of progesterone receptor (PR) suggesting that TGF?
Positive_regulation (suggesting) of Gene_expression (expression) of progesterone receptor
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.23 Pain Relevance 0.14
Letrozole plus trastuzumab produced durable responses in about one in four patients with ER/PR+, HER2+ metastatic breast cancer, but early progression occurred in one in two patients [59].
Positive_regulation (responses) of Gene_expression (produced) of PR associated with advanced or metastatic breast cancer
14) Confidence 0.12 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.75 Pain Relevance 0.12
Evidence shows that one effect of estrogen is to increase the levels of both estrogen receptor (ER) and progesterone receptor (PR) [2].
Positive_regulation (increase) of Gene_expression (levels) of PR
15) Confidence 0.08 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.84 Pain Relevance 0.10
Evidence shows that one effect of estrogen is to increase the levels of both estrogen receptor (ER) and progesterone receptor (PR) [2].
Positive_regulation (increase) of Gene_expression (levels) of progesterone receptor
16) Confidence 0.08 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.84 Pain Relevance 0.10
Electrocardiogram parameters determined should include PR, QT, and QRS interval prolongation (?
Positive_regulation (include) of Gene_expression (prolongation) of PR
17) Confidence 0.03 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 1.32 Pain Relevance 0.05
From a pediatrician’s point of view, the lack of an influence of ESL on the clearance of sodium valproate, topiramate, phenobarbital, carbamazepine, clobazam, gabapentin, and levetiracetam, as well as no evidence of QT prolongation, is of importance (although the evaluation of electrocardiogram recordings during clinical trials showed an increase in PR interval in ESL-treated adults, which was highest in the 1200 mg dose group when compared with placebo).29

Drug interactions

Positive_regulation (increase) of Gene_expression (interval) of PR associated with gabapentin and carbamazepine
18) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.14 Pain Relevance 0.17
Pathogenesis-related proteins can also be induced in leaves and berries as part of a defensive response to the classical PR protein gene-inducers (wounding, chemical elicitors, pathogen attack, or abiotic stress) by the expression of specific PR genes (Jacobs et al. 1999; Robinson and Davies 2000).
Positive_regulation (induced) of Gene_expression (expression) of PR associated with stress
19) Confidence 0.02 Published 2009 Journal Phytochem Rev Section Body Doc Link PMC2928446 Disease Relevance 0.34 Pain Relevance 0

General Comments

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