INT93887

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 14
Disease Relevance 2.63
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESRRA) nucleus (ESRRA) DNA binding (ESRRA)
Anatomy Link Frequency
myoblasts 1
mammary gland 1
ESRRA (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 5 89.92 High High
ischemia 123 84.88 Quite High
Somatostatin 7 79.04 Quite High
fibrosis 1 76.80 Quite High
agonist 29 74.92 Quite High
Dismenorea 1 60.00 Quite High
addiction 2 44.32 Quite Low
antagonist 20 28.32 Quite Low
depression 5 20.28 Low Low
Angina 22 8.80 Low Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 26 94.88 High High
Reprotox - General 1 98 92.64 High High
Cancer 12 87.24 High High
Cytomegalovirus Infection 22 85.76 High High
Coronary Artery Disease 44 84.88 Quite High
Hyperplasia 3 84.40 Quite High
Diabetes Mellitus 533 83.52 Quite High
Disease 47 81.00 Quite High
Fibrosis 1 76.80 Quite High
Myocardial Infarction 25 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, based on the characteristic nucleotide sequence [32], [33], on known similarities in tissue expression between ERR and PPAR?
Gene_expression (expression) of ERR
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
PPARA promoter-reporter constructs were cotransfected with empty expression vector or vector expressing ERR?
Gene_expression (expressing) of ERR
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.16 Pain Relevance 0
We previously found that ERR?
Gene_expression (found) of ERR
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.79 Pain Relevance 0.08
PPARA promoter-reporter constructs were cotransfected with empty expression vector or vector expressing ERR?
Gene_expression (cotransfected) of ERR
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.16 Pain Relevance 0
When co-transfected with an ERR?
Gene_expression (transfected) of ERR
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
Both ERR?
Gene_expression (Both) of ERR
6) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
Again, the results were similar with co-transfection of ERR?
Gene_expression (transfection) of ERR
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.16 Pain Relevance 0.04
54,642 A was observed with ERR?
Gene_expression (observed) of ERR
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
in C2C12 myoblasts was masking PPARA/TK A promoter-reporter activation by transfected ERR?
Gene_expression (transfected) of ERR in myoblasts
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.05 Pain Relevance 0
PPARA promoter-reporter constructs were cotransfected with empty expression vector or vector expressing ERR?
Gene_expression (expression) of ERR
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.16 Pain Relevance 0
, we repeated the experiments in CV1 cells that are null for endogenous ERR?
Gene_expression (null) of ERR
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.11 Pain Relevance 0.03
We evaluated endometrial and mammary gland histopathology and morphometry and used immunohistochemistry to evaluate cell proliferation and expression of estrogen receptor alpha and progesterone receptor (PR).
Gene_expression (expression) of estrogen receptor alpha in mammary gland
12) Confidence 0.12 Published 2001 Journal Toxicol Pathol Section Abstract Doc Link 11215689 Disease Relevance 0.48 Pain Relevance 0.10
Compared to E2 administration alone, testosterone reduced E2-induced proliferation by approximately 40% and entirely abolished E2-induced augmentation of estrogen receptor alpha expression [36].
Gene_expression (expression) of estrogen receptor alpha
13) Confidence 0.08 Published 2010 Journal J Cancer Surviv Section Body Doc Link PMC2921487 Disease Relevance 0.41 Pain Relevance 0
Gastric ghrelin-secreting cells express estrogen receptor-alpha [103], thus potentially mediating some sex-steroid effects.
Gene_expression (express) of estrogen receptor-alpha
14) Confidence 0.06 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.16 Pain Relevance 0.12

General Comments

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