INT9389

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 14
Total Number 19
Disease Relevance 2.23
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
hypothalamus 1
adrenal medulla 1
brain 1
midbrain 1
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 93 100.00 Very High Very High Very High
Enkephalin 47 100.00 Very High Very High Very High
headache 13 100.00 Very High Very High Very High
narcan 10 100.00 Very High Very High Very High
midbrain 4 99.68 Very High Very High Very High
aspirin 3 98.40 Very High Very High Very High
Migraine 6 98.16 Very High Very High Very High
Neuropeptide 16 98.04 Very High Very High Very High
substance P 2 97.88 Very High Very High Very High
medulla 14 97.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 13 100.00 Very High Very High Very High
Paroxysmal Hemicrania 11 100.00 Very High Very High Very High
Alcohol Addiction 2 100.00 Very High Very High Very High
Headache 8 98.16 Very High Very High Very High
Insulin Coma 4 95.60 Very High Very High Very High
Pain 1 90.88 High High
Disease 9 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Drug Dependence 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reflex splanchnic stimulation of the rat adrenal medulla, which has previously been found to substantially increase enkephalin mRNA and enkephalin peptide levels, was examined for an influence on CPE mRNA and enzymatic activity.
Spec (examined) Regulation (influence) of CPE in adrenal medulla associated with medulla and enkephalin
1) Confidence 0.61 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2370548 Disease Relevance 0.06 Pain Relevance 0.53
Our case report is the first to demonstrate complete control of CPH in a 9 year-old child using small dose aspirin prophylaxis.
Regulation (control) of CPH associated with aspirin and headache
2) Confidence 0.61 Published 1989 Journal Headache Section Abstract Doc Link 2745065 Disease Relevance 0.37 Pain Relevance 0.55
Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing.
Regulation (Regulation) of carboxypeptidase H associated with neuropeptide and enkephalin
3) Confidence 0.60 Published 1988 Journal Cell. Mol. Neurobiol. Section Title Doc Link 3135937 Disease Relevance 0 Pain Relevance 0.28
The time course of the change in CPE mRNA levels is similar to that previously found for proenkephalin mRNA.
Regulation (change) of CPE
4) Confidence 0.45 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2370548 Disease Relevance 0.10 Pain Relevance 0.51
The changes in CPE mRNA and enzymatic activity are consistent with the proposal that CPE is not a rate-limiting enzyme in the biosynthesis of enkephalin.
Regulation (changes) of CPE associated with enkephalin
5) Confidence 0.45 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2370548 Disease Relevance 0.09 Pain Relevance 0.49
[Effect of an enkephalin-like tetrapeptide on the food instrumental behavior of rats].
Regulation ([Effect) of enkephalin-like tetrapeptide associated with narcan and enkephalin
6) Confidence 0.44 Published 1983 Journal Biull Eksp Biol Med Section Title Doc Link 6616049 Disease Relevance 0 Pain Relevance 0.28
Because of the importance of posttranslational processing as a regulatory step for the production of active peptides, recent studies investigating control mechanisms for carboxypeptidase H (CPH) are reviewed. 3.
Spec (investigating) Regulation (control) of CPH
7) Confidence 0.44 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 3135937 Disease Relevance 0 Pain Relevance 0.17
Because of the importance of posttranslational processing as a regulatory step for the production of active peptides, recent studies investigating control mechanisms for carboxypeptidase H (CPH) are reviewed. 3.
Spec (investigating) Regulation (control) of carboxypeptidase H
8) Confidence 0.44 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 3135937 Disease Relevance 0 Pain Relevance 0.17
[The effect of naloxone on the activation, inducible by chronic alcoholic intoxication, of the membrane-bound form of enkephalin convertase in the midbrain and hypothalamus of rats].
Regulation (effect) of enkephalin convertase in midbrain associated with alcohol addiction, narcan, midbrain and enkephalin
9) Confidence 0.39 Published 1992 Journal Biull Eksp Biol Med Section Title Doc Link 1467484 Disease Relevance 0.10 Pain Relevance 0.74
[Effect of stress factors on carboxypeptidase H activity in areas of the rat brain].
Regulation (Effect) of carboxypeptidase H in brain associated with stress
10) Confidence 0.27 Published 1992 Journal Ukr. Biokhim. Zh. Section Title Doc Link 1413117 Disease Relevance 0.38 Pain Relevance 0.09
The time course of the changes in CPE activity is different from those of the changes in epinephrine levels and the previously reported changes in enkephalin peptide levels.
Regulation (changes) of CPE associated with enkephalin
11) Confidence 0.23 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2370548 Disease Relevance 0.09 Pain Relevance 0.50
Treatment with indomethacin had a dramatic effect on the CPH attacks but did not modify the course of the migraine.
Regulation (effect) of CPH associated with migraine and headache
12) Confidence 0.23 Published 1992 Journal Headache Section Abstract Doc Link 1551791 Disease Relevance 0.96 Pain Relevance 1.16
Inhibition by amidated peptide products (vasopressin, oxytocin, luteinizing hormone-releasing hormone, substance P, and thyrotropin-releasing hormone) show that the final products of the precursor processing pathway can regulate carboxypeptidase H.
Regulation (regulate) of carboxypeptidase H associated with substance p
13) Confidence 0.22 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2887569 Disease Relevance 0 Pain Relevance 0.72
Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A.
Regulation (regulated) of carboxypeptidase E associated with enkephalin
14) Confidence 0.21 Published 1998 Journal Endocrinology Section Title Doc Link 9529003 Disease Relevance 0 Pain Relevance 0.20
Taken together, these data indicated that the binding of DAT-CT tail583–620 sequences to CPE was both sufficient and necessary for the expression of CPE- mediated functional regulation of the DA translocation process.


Regulation (regulation) of CPE associated with dopamine
15) Confidence 0.16 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.25
Regulation of dopamine transporter activity by carboxypeptidase E

Background

Regulation (Regulation) of carboxypeptidase E associated with dopamine
16) Confidence 0.16 Published 2009 Journal Mol Brain Section Title Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.19
The present finding highlighted the importance of CPE in trafficking and metabolic processing of DAT.
Regulation (importance) of CPE
17) Confidence 0.14 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.12
[The effect of naloxone on the activation, inducible by chronic alcoholic intoxication, of the membrane-bound form of enkephalin convertase in the midbrain and hypothalamus of rats].
Regulation (effect) of enkephalin convertase in hypothalamus associated with alcohol addiction, narcan, midbrain and enkephalin
18) Confidence 0.13 Published 1992 Journal Biull Eksp Biol Med Section Title Doc Link 1467484 Disease Relevance 0.10 Pain Relevance 0.74
Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor.
Regulation (regulated) of carboxypeptidase E associated with enkephalin
19) Confidence 0.05 Published 1999 Journal Mol. Endocrinol. Section Title Doc Link 10194759 Disease Relevance 0 Pain Relevance 0.10

General Comments

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