INT9390

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.31
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
NG108-15 2
vas deferens 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 13 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
Morphine 5 100.00 Very High Very High Very High
antagonist 18 99.98 Very High Very High Very High
opioid receptor 29 99.74 Very High Very High Very High
Paracetamol 2 99.28 Very High Very High Very High
Immobilon 6 98.24 Very High Very High Very High
Inflammation 4 97.52 Very High Very High Very High
cytokine 2 97.36 Very High Very High Very High
Hyperalgesia 1 96.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 97.52 Very High Very High Very High
Hyperalgesia 1 96.62 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 96.32 Very High Very High Very High
Cancer 1 86.40 High High
Necrosis 1 85.92 High High
Neuroblastoma 1 75.00 Quite High
Glioma 1 75.00 Quite High
Nociception 5 55.96 Quite High
Pain 7 41.76 Quite Low
Inflammatory Pain 3 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the hyperalgesia, as a consequence of peripheral inflammation induced by a variety of agents, is associated with increased dynorphin expression [18-20], and opioid receptor antagonists reversed the decrease in dynorphin level induced by paracetamol [21].
Negative_regulation (reversed) of Negative_regulation (decrease) of dynorphin associated with paracetamol, hyperalgesia, dynorphin, inflammation, antagonist and opioid receptor
1) Confidence 0.42 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.32 Pain Relevance 1.77
The hypothalamic isolation prevented both the inhibitory effect of Leu-enkephalin on the rumen motility and the drug induced psychosedative action.
Negative_regulation (prevented) of Negative_regulation (inhibitory) of Leu-enkephalin associated with enkephalin
2) Confidence 0.42 Published 1992 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 1414089 Disease Relevance 0 Pain Relevance 0.55
The presence of a vas deferens tissue prevented the current-induced loss of activity of Leu-enkephalin but had no effect on the loss of activity of Met-enkephalin.
Negative_regulation (prevented) of Negative_regulation (loss) of Leu-enkephalin in vas deferens associated with enkephalin
3) Confidence 0.20 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7215438 Disease Relevance 0 Pain Relevance 0.58
Pretreatment for 30 min with the kappa receptor antagonist nor-binaltorphimine completely blocked the stimulatory effect of dynorphin and U50,488.
Negative_regulation (blocked) of Negative_regulation (effect) of dynorphin associated with dynorphin and antagonist
4) Confidence 0.06 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7669075 Disease Relevance 0.84 Pain Relevance 0.68
Exposure to 100 microM morphine for 72 hr produced a complete loss of morphine and levorphanol but not Leu5-enkephalin activity in NG108-15 hybrid cells.
Negative_regulation (produced) of Negative_regulation (loss) of Leu5-enkephalin in NG108-15 associated with enkephalin and morphine
5) Confidence 0.01 Published 1982 Journal Mol. Pharmacol. Section Abstract Doc Link 6126803 Disease Relevance 0.15 Pain Relevance 0.96

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox