INT93911

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 4.94
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COX5A) small molecule metabolic process (COX5A)
Anatomy Link Frequency
neurons 1
ureter 1
platelet 1
astrocytes 1
HSG 1
COX5A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 99.98 Very High Very High Very High
cINOD 30 99.96 Very High Very High Very High
tetrodotoxin 3 99.72 Very High Very High Very High
diclofenac 8 99.52 Very High Very High Very High
aspirin 15 99.48 Very High Very High Very High
Pain 22 98.80 Very High Very High Very High
Opioid 61 98.48 Very High Very High Very High
Lasting pain 14 97.92 Very High Very High Very High
COX-2 inhibitor 9 97.84 Very High Very High Very High
colic 3 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 26 99.98 Very High Very High Very High
INFLAMMATION 22 99.98 Very High Very High Very High
Rheumatoid Arthritis 6 99.38 Very High Very High Very High
Pain 39 98.80 Very High Very High Very High
Fever 1 97.92 Very High Very High Very High
Cancer Pain 6 97.24 Very High Very High Very High
Renal Colic 3 97.04 Very High Very High Very High
Ovarian Cancer 4 96.00 Very High Very High Very High
Malignant Neoplastic Disease 2 94.60 High High
Skin Cancer 1 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the hypothesis that natural agents capable of modulating both lipoxygenase and COX may advance the efficacy of cancer therapy, an overview and discussion is presented of dietary modifications and selected nutritional and botanical agents (notably, omega-3 fatty acids, antioxidants, boswellia, bromelain, curcumin, and quercetin) that favorably influence eicosanoid production.
Regulation (modulating) of COX associated with cancer
1) Confidence 0.60 Published 2002 Journal Integr Cancer Ther Section Abstract Doc Link 14664746 Disease Relevance 0.95 Pain Relevance 0.27
Therefore, we studied the influence of the non-selective cyclooxygenase (COX) inhibitor diclofenac, a NSAID drug customarily used in the treatment of renal colic, and of NS-398, a selective COX-2 inhibitor, on induced contractions of the pig ureter.
Regulation (influence) of COX in ureter associated with colic, cinod, cox-2 inhibitor, diclofenac and renal colic
2) Confidence 0.44 Published 2000 Journal Urol. Res. Section Abstract Doc Link 11221916 Disease Relevance 0.35 Pain Relevance 0.72
The effects of a nonselective COX inhibitor or specific inhibitors of COX-1 or COX-2 following oral administration on the content of ectopic bone and PGE(2) were also measured.
Regulation (effects) of COX
3) Confidence 0.44 Published 2008 Journal Arch Orthop Trauma Surg Section Body Doc Link 18034350 Disease Relevance 0.07 Pain Relevance 0
In this study, we examined the anti-tumor effects of the non-specific cyclooxygenase (COX) inhibitors aspirin and piroxicam, and the selective COX-2 inhibitor meloxicam on xenotransplanted ovarian cancer.
Spec (examined) Regulation (effects) of COX associated with aspirin, cancer, ovarian cancer and cox-2 inhibitor
4) Confidence 0.44 Published 2007 Journal Pathol. Oncol. Res. Section Abstract Doc Link 18158574 Disease Relevance 1.17 Pain Relevance 0.50
In addition, the effects of the NSAID sulindac and other cyclooxygenase (COX) inhibitors on Stat3 and survivin expression and on cell proliferation and apoptosis of HSY and HSG cells were analyzed.
Spec (analyzed) Regulation (effects) of COX in HSG
5) Confidence 0.44 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19272804 Disease Relevance 0.18 Pain Relevance 0
Silencing of NRF-1 with small interference RNA prevented the depolarization-stimulated up-regulation of Gria2 and COX, and over-expression of NRF-1 rescued neurons from tetrodotoxin-induced down-regulation of Gria2 and COX transcripts.
Regulation (regulation) of COX in neurons associated with tetrodotoxin
6) Confidence 0.44 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.18
These differences include the effects on the cyclooxygenase (COX)-1 isoenzyme, local effects on the gastroduodenal mucosa specific to ASA and a reduction in platelet aggregation.
Regulation (effects) of COX in platelet
7) Confidence 0.26 Published 2009 Journal Curr Med Res Opin Section Body Doc Link 19788350 Disease Relevance 0 Pain Relevance 0
We hypothesized that the coupling existed at the transcriptional level by having the same transcription factor to regulate a marker of energy metabolism, cytochrome c oxidase (COX) and an important subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors, GluR2 (Gria2).
Regulation (regulate) of COX associated with glutamate receptor
8) Confidence 0.26 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.14
Nuclear respiratory factor 1 (NRF-1) was a viable candidate because it regulates all COX subunits and potentially activates Gria2.
Regulation (regulates) of COX in respiratory
9) Confidence 0.26 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.15
Numerous in vitro assay systems have been developed for testing and comparing the relative inhibitory activities of nonsteroidal anti-inflammatory drugs (NSAIDs) against cyclooxygenase (COX)- 1 and COX-2, the two COX isoforms responsible for prostaglandin biosynthesis.
Regulation (responsible) of COX associated with inflammation and cinod
10) Confidence 0.26 Published 1998 Journal J Clin Rheumatol Section Abstract Doc Link 19078321 Disease Relevance 0.10 Pain Relevance 0.40
RA counteracted the inflammatory regulation of cyclooxygenase (COX)-2 mRNA and protein in astrocytes and thereby reduced the synthesis of PGE(2) by approximately 60%.
Regulation (regulation) of COX in astrocytes associated with inflammation and rheumatoid arthritis
11) Confidence 0.26 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18394023 Disease Relevance 0.86 Pain Relevance 0.29
Non-steroidal anti-inflammatory drugs (NSAID) target the enzyme cyclooxygenase (COX) thus affording relieve from pain, inflammation or fever.
Regulation (target) of COX associated with pain, inflammation, cinod and fever
12) Confidence 0.26 Published 2006 Journal Mini Rev Med Chem Section Abstract Doc Link 17168811 Disease Relevance 0.80 Pain Relevance 0.76
To operationalize the 2003 VA/DOD 'Clinical Practice Guideline for Opioid Therapy for Chronic Non-Cancer Pain', the KM, the medical director, and clinical nurse specialist who direct the VA Palo Alto Health Care System Pain Management Clinic worked collaboratively to create a draft of the guideline knowledge to be encoded in Protégé and specify concepts that were not clearly defined.
Regulation (operationalize) of VA associated with pain, cancer pain and opioid
13) Confidence 0.01 Published 2010 Journal Implement Sci Section Body Doc Link PMC2868045 Disease Relevance 0.47 Pain Relevance 0.65

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