INT93912

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 7.01
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80) intracellular (CD80) cell-cell signaling (CD80)
Anatomy Link Frequency
CD86 5
T-cell 3
blood 2
monocytes 1
dendritic cells 1
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 23 99.46 Very High Very High Very High
cytokine 66 98.44 Very High Very High Very High
chemokine 35 98.34 Very High Very High Very High
Inflammation 29 97.84 Very High Very High Very High
rheumatoid arthritis 10 97.12 Very High Very High Very High
Central nervous system 19 96.92 Very High Very High Very High
methotrexate 1 95.28 Very High Very High Very High
Neuritis 2 85.92 High High
Inflammatory mediators 1 71.12 Quite High
agonist 20 70.24 Quite High
Disease Link Frequency Relevance Heat
Infection 455 98.72 Very High Very High Very High
INFLAMMATION 47 97.84 Very High Very High Very High
Rheumatoid Arthritis 10 97.12 Very High Very High Very High
Chlamydia Infection 88 94.24 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 167 89.44 High High
Neurocysticercosis 30 89.36 High High
Neurological Disease 4 88.48 High High
Body Weight 7 87.44 High High
Influenza Virus Infection 69 86.24 High High
Optic Neuritis 2 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The myeloid dendritic cells in CSF expressed higher levels of HLA-DR, CD86, CD80 and CD40 than those in blood, whereas expression of these molecules by plasmacytoid dendritic cells was equal in blood and CSF.
Positive_regulation (levels) of CD80 in blood
1) Confidence 0.56 Published 2001 Journal Brain Section Abstract Doc Link 11222448 Disease Relevance 1.00 Pain Relevance 0.43
Abatacept is a recombinant soluble fusion protein that inhibits the CD80/CD86:CD28 costimulatory signal required for T cell activation and has demonstrated efficacy in the treatment of rheumatoid arthritis.
Positive_regulation (required) of CD80 in T cell associated with rheumatoid arthritis and abatacept
2) Confidence 0.49 Published 2007 Journal J Clin Pharmacol Section Abstract Doc Link 17962428 Disease Relevance 0.34 Pain Relevance 0.39
Abatacept selectively modulates the CD80/CD86:CD28 co-stimulatory signal required for full T-cell activation, and has been approved for the treatment of rheumatoid arthritis (RA) in combination with methotrexate in a number of countries, including the United States, Canada, and the European Union.
Positive_regulation (required) of CD80 in T-cell associated with rheumatoid arthritis, abatacept and methotrexate
3) Confidence 0.49 Published 2007 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 17977488 Disease Relevance 0.38 Pain Relevance 0.53
In normal immunologic responses, TLR activation of monocytes and DCs results in activation of costimulatory molecules CD80 and CD86.
Positive_regulation (activation) of CD80 in monocytes
4) Confidence 0.25 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.44 Pain Relevance 0.04
Mature DCs express high levels of Class I and Class II molecules, altered chemokine and galectin family (Dietz et al 2000; Bax et al 2007) expression, co-stimulatory markers CD80 and CD86, and the immunoglobulin CD83 (Zhou and Tedder 1995).
Positive_regulation (markers) of CD80 in CD86 associated with chemokine
5) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.29 Pain Relevance 0.09
The increase in CD80 at week 32 suggested mDC were again activated during the period of ART discontinuation, although no increase in CCR7 or CD86 expression was noted at this time (Figure 3A–C).
Positive_regulation (increase) of CD80 in CD86
6) Confidence 0.21 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.72 Pain Relevance 0.04
At day 7 of treatment, the elevated CD80 expression by PDCs (Fig.
Positive_regulation (elevated) of CD80
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0.25 Pain Relevance 0
Expression of the costimulatory molecules CD80 and CD86 was markedly increased in all animals at 2 weeks post infection indicative of rapid mDC activation (Figure 3A–D).
Positive_regulation (increased) of CD80 in CD86 associated with infection
8) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.94 Pain Relevance 0.04
The 12-week course ART was effective at reducing blood mDC activation, particularly with respect to CD80, and in animals in the stable group expression of all markers of activation returned to preinfection levels during ART (Figure 3A–C).
Positive_regulation (activation) of CD80 in blood
9) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.82 Pain Relevance 0.04
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Positive_regulation (upregulated) of CD80 in dendritic cells
10) Confidence 0.16 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
Likewise, dendritic cells stimulated with helminth components show limited upregulation of CD80, CD86 and MHC-II expression in comparison to the expression induced by bacterial antigens [37].
Positive_regulation (upregulation) of CD80 in CD86
11) Confidence 0.10 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.61 Pain Relevance 0.08
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
Positive_regulation (required) of CD80 in T lymphocytes associated with cytokine
12) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.25 Pain Relevance 0.08
After 7 days of cultivation in vitro, the cells turned into DCs, as indicated by the loss of CD14 receptors and the upregulation of HLA-DR, CD80 and CD86 receptors (data not shown).
Positive_regulation (upregulation) of CD80 in CD86
13) Confidence 0.09 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.97 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox