INT93913

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 35
Disease Relevance 23.47
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
CD86 9
plasma 2
chest 2
dendritic cells 1
platelet 1
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 138 99.56 Very High Very High Very High
Inflammation 655 99.36 Very High Very High Very High
Angina 5 98.36 Very High Very High Very High
chemokine 150 97.40 Very High Very High Very High
cva 2 96.84 Very High Very High Very High
rheumatoid arthritis 100 88.56 High High
Neuritis 2 85.92 High High
Chronic pancreatitis 150 80.24 Quite High
Multiple sclerosis 3 72.08 Quite High
Inflammatory mediators 22 70.68 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 1350 99.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 99.66 Very High Very High Very High
INFLAMMATION 688 99.36 Very High Very High Very High
Hyperlipidemia 4 99.24 Very High Very High Very High
Acute Coronary Syndrome 6 99.16 Very High Very High Very High
Chronic Lymphoid Leukemia 4 98.62 Very High Very High Very High
Hepatitis C Virus Infection 30 98.52 Very High Very High Very High
Cv General 3 Under Development 4 98.36 Very High Very High Very High
Peripheral Arterial Disease 6 98.04 Very High Very High Very High
Apoptosis 136 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The myeloid dendritic cells in CSF expressed higher levels of HLA-DR, CD86, CD80 and CD40 than those in blood, whereas expression of these molecules by plasmacytoid dendritic cells was equal in blood and CSF.
Positive_regulation (levels) of CD40 in blood
1) Confidence 0.58 Published 2001 Journal Brain Section Abstract Doc Link 11222448 Disease Relevance 1.00 Pain Relevance 0.43
T cell surface molecules, some of them upregulated on activation, such as CD69 [2,3], CD23 [4,5], integrins [6], CD40-CD40 ligand [7], LAG-3 [8], CD45 [9], LFA-1 and ICAM-1 [10] and membrane-bound cytokines [11] have all been implicated in this activation.
Positive_regulation (upregulated) of CD40 in T cell associated with cytokine
2) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 1.02 Pain Relevance 0.42
The combined plasma induced upregulation of CD40 (median 118, median 98), and CD86, (median 105, median 112), in both MDCs and PDCs.
Positive_regulation (upregulation) of CD40 in plasma
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.57 Pain Relevance 0.03
The DCs in the HIV patients showed increased CD40 on MDCs and decreased CD86 on PDCs [42].
Positive_regulation (increased) of CD40 in CD86 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.51 Pain Relevance 0.21
The CD83, CD40 and CD86 are upregulated as a step in the maturation process and have a role in immune modulation [38].
Positive_regulation (upregulated) of CD40 in CD86
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.16 Pain Relevance 0.16
CD83 is a glycoprotein that is upregulated together with costimulatory molecules, such as CD40 and CD86, thus suggesting a role in the induction of immune responses [38].
Positive_regulation (upregulated) of CD40 in CD86
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.85 Pain Relevance 0.04
When MDCs and PDCs undergo phenotypic maturation certain factors, for instance CD83, CD40, HLA DR, B7H3 (CD276) and CCR7 are upregulated, whereas DCIR, ICOSL (CD275) [18], and several tissue retaining chemokine receptors (CCR1, CCR2, CCR3, CCR5 and, CCR8) are down modulated and as a consequence the DCs will migrate to the local lymphatic tissue [19], [20], [21].
Positive_regulation (upregulated) of CD40 associated with chemokine
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.58 Pain Relevance 0.15
Patients infected with gram-negative bacteria or EBV showed a marked increase in monocyte CD40, while this effect was less pronounced for tuberculosis, borrelia and influenza.
Positive_regulation (increase) of CD40 in monocyte
8) Confidence 0.32 Published 2010 Journal BMC Infect. Dis. Section Body Doc Link 20626864 Disease Relevance 0.06 Pain Relevance 0
Thus, targeting CD40 rather than its ligand was considered as an alternative, so as to avoid these thromboembolic complications.
Positive_regulation (targeting) of CD40 associated with cva
9) Confidence 0.30 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.18 Pain Relevance 0.09
In addition, the CD40 gene and its transduction factor TRAF-3, as well as the nuclear factor (NF)-kB activator Ripk2 gene, were up-regulated, suggesting an inflammatory activation of tubular cells (Figure 4F).
Positive_regulation (regulated) of CD40 gene associated with inflammation
10) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.81 Pain Relevance 0.09
In addition, the CD40 gene and its transduction factor TRAF-3, as well as the nuclear factor (NF)-kB activator Ripk2 gene, were up-regulated, suggesting an inflammatory activation of tubular cells (Figure 4F).
Positive_regulation (up) of CD40 gene associated with inflammation
11) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.81 Pain Relevance 0.09
Up-regulation of CD40 was confirmed by FACS analysis (Figure 4G).
Positive_regulation (regulation) of CD40
12) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.66 Pain Relevance 0.09
One hypothesis is that with the loss of binding of muramyl dipeptide to NOD2, there is a compensatory response with failure to inhibit the activation of c-Rel and p50 by binding of peptidoglycan to the toll-like receptor 2.58 This results in the downstream activation of IL-12 and consequent inflammation.
Positive_regulation (activation) of p50 associated with inflammation
13) Confidence 0.28 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780674 Disease Relevance 0.63 Pain Relevance 0.09
Of note, induction of mRNAs for CD40, CD86, and HLA-DR in ??
Positive_regulation (induction) of CD40 in CD86
14) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0
We also measured the level of CD40, i.e. a costimulatory molecule important for the activation and survival of DCs and found significantly increased levels of CD40 on MDCs and PDCs both before (median 432; median 584) and after tumor resection (median 524, median 656), compared to those expressed on control MDCs (median 322) and PDCs (median 349) (Figure 2B).
Positive_regulation (increased) of CD40 associated with cancer
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.85 Pain Relevance 0.03
The TLR9 ligation on PDCs induced a mature phenotype with upregulation of CD40, CD83, CD86, CCR7, PDL-1, ICOSL and CCR5 and decreased B7H3 and DCIR (Figure 9).
Positive_regulation (upregulation) of CD40 in PDL-1
16) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.30 Pain Relevance 0.03
RESULTS: The levels of soluble CD40 ligand were increased in 57.8% patients with ACS (>8.0 ng/ml) and in 35 patients with acute chest pain (>8.0 ng/ml), respectively.
Positive_regulation (increased) of CD40 in chest
17) Confidence 0.25 Published 2004 Journal Clin. Chim. Acta Section Body Doc Link 15115688 Disease Relevance 0.18 Pain Relevance 0
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (enhanced) of CD40 in CD86
18) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Spec (clear) Positive_regulation (activation) of CD40 in CD86
19) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.72 Pain Relevance 0.06
Increased levels of CD40 and CD83 were observed on PDCs from HCV infected patients [13], whereas MDCs were less affected [13].
Positive_regulation (Increased) of CD40 associated with hepatitis c virus infection
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.15 Pain Relevance 0.18

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