INT93914

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 70
Total Number 72
Disease Relevance 36.35
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80) intracellular (CD80) cell-cell signaling (CD80)
Anatomy Link Frequency
CD86 24
T-cells 10
B-cells 7
blood 4
GIM 2
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 158 100.00 Very High Very High Very High
tolerance 120 100.00 Very High Very High Very High
cytokine 665 99.50 Very High Very High Very High
Inflammation 498 98.52 Very High Very High Very High
Central nervous system 41 96.28 Very High Very High Very High
abatacept 262 95.68 Very High Very High Very High
rheumatoid arthritis 324 94.68 High High
Potency 15 94.48 High High
psoriasis 16 93.26 High High
Inflammatory marker 1 87.96 High High
Disease Link Frequency Relevance Heat
Cancer 2180 99.84 Very High Very High Very High
Cold Sores 1421 99.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 590 99.02 Very High Very High Very High
Skin Cancer 106 98.56 Very High Very High Very High
INFLAMMATION 558 98.52 Very High Very High Very High
Disease 325 98.52 Very High Very High Very High
Breast Cancer 19 98.08 Very High Very High Very High
Renal Cancer 47 97.90 Very High Very High Very High
Helminth Infection 12 97.88 Very High Very High Very High
Infection 1406 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They do not depend on the B7/CD28 pathway for activation, do not express the CD80 receptor, are incapable of activating B cells, have significant cytolytic activity, and express high levels of IFN-?
Neg (not) Gene_expression (express) of CD80 in B cells
1) Confidence 0.75 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165060 Disease Relevance 0.37 Pain Relevance 0.13
We have recently observed that O3 exposure can also result in increased expression of CD11b, CD14, CD16, CD80, CD86, and HLA-DR on airway dendritic cells (DCs), monocytes, and macrophages (Alexis et al. 2004b).
Gene_expression (expression) of CD80 in macrophages
2) Confidence 0.75 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 1.12 Pain Relevance 0.14
In the T-cell activation process, CD4+ T-cells are engaged by antigenic peptide fragments in a complex with HLA class II molecules, in addition to co-stimulatory molecules, such as CD80/CD86, expressed on the surface of professional antigen presenting cells.
Gene_expression (expressed) of CD80 in T-cells
3) Confidence 0.75 Published 2007 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 17977483 Disease Relevance 1.29 Pain Relevance 0.43
Freshly isolated human islet ECs constitutively expressed CD86 (B7-2) and ICOS ligand but not CD80 (B7-1) or CD40 costimulatory molecules.
Neg (not) Gene_expression (expressed) of CD80 in ECs
4) Confidence 0.75 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18941200 Disease Relevance 0.46 Pain Relevance 0.09
There is no longer a unique role for professional antigen-presenting cells that express CD80/CD86, but other cell types can be T-cell stimulatory.
Gene_expression (express) of CD80 in T-cell
5) Confidence 0.75 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 1.23 Pain Relevance 0.38
The myeloid dendritic cells in CSF expressed higher levels of HLA-DR, CD86, CD80 and CD40 than those in blood, whereas expression of these molecules by plasmacytoid dendritic cells was equal in blood and CSF.
Gene_expression (expressed) of CD80 in blood
6) Confidence 0.62 Published 2001 Journal Brain Section Abstract Doc Link 11222448 Disease Relevance 1.01 Pain Relevance 0.43
RESULTS: When maintained in an alginate matrix, chondrocytes isolated from the femoral heads of patients with AS constitutively expressed type II collagen and CD80.
Gene_expression (expressed) of CD80 in heads
7) Confidence 0.62 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19479861 Disease Relevance 0.07 Pain Relevance 0
T cell activation requires antigen recognition by the T cell receptor, referred to as signal 1, as well as a co-stimulatory signal, referred to as signal 2.2 One of the best characterised co-stimulatory pathways involves the interaction of CD28 expressed on T cells with CD80 and CD86 expressed on antigen-presenting cells.
Gene_expression (expressed) of CD80 in CD86
8) Confidence 0.58 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2569144 Disease Relevance 0.52 Pain Relevance 0.42
This signal is mediated by CD80 and CD86, which is expressed on antigen-presenting cells, and by CD28, which is expressed on T cells.
Gene_expression (expressed) of CD80 in CD86
9) Confidence 0.51 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906816 Disease Relevance 0.16 Pain Relevance 0.68
The inhibition of the CD80/CD86:CD28 co-stimulatory signal may also potentially prevent the T-cell 'help' needed for optimal differentiation of CD80/CD86-expressing B cells into plasma cells, which ultimately secrete antibodies.
Gene_expression (expressing) of CD80 in B cells
10) Confidence 0.51 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906816 Disease Relevance 0.16 Pain Relevance 0.43
The lack of expression of B7-1 and B7-2 on the surface of effector cells results in lower susceptibility to suppression exerted by CD4+CD25+ T-cells.
Gene_expression (expression) of B7 in T-cells
11) Confidence 0.48 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.06
In vivo suppression also requires B7 expression on effector cells.
Gene_expression (expression) of B7
12) Confidence 0.48 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.04
The lack of expression of B7-1 and B7-2 on the surface of effector cells results in lower susceptibility to suppression exerted by CD4+CD25+ T-cells.
Gene_expression (expression) of B7 in T-cells
13) Confidence 0.48 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.06
However, here we demonstrated that hookworm ES products may be partially responsible for the alternative differentiation of DC, as observed by the reduction of CD11c and CD86 expression and increase of CD80 expression on the DC surface.
Gene_expression (expression) of CD80 in CD86 associated with hookworm infection
14) Confidence 0.48 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.48 Pain Relevance 0.12
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Gene_expression (levels) of CD80 in dendritic cells
15) Confidence 0.46 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
Similarly, in NHP models, when recipient splenic T-cells are cocultured with irradiated donor splenocytes in the presence of both anti-human CD80 and CD86 mAbs and re-injected into recipient, graft survival was indefinite in 50% of cases (Bashuda et al 2005).
Gene_expression (mAbs) of CD80 in CD86
16) Confidence 0.42 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.09 Pain Relevance 0
CD40 stimulation triggers important signals for antibody production by B cells and strongly induces B7 and MHC expression on APCs.
Gene_expression (expression) of B7 in B cells
17) Confidence 0.42 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
Monocyte-derived dendritic cells differentiated in the presence of N. americanus excreted-secreted products both from adult worm (ESAw) and L3 larvae (ESL3) showed a significant decreased expression of CD11c and CD86 while presented higher expression of CD80 (Fig 2).
Gene_expression (expression) of CD80 in CD86 associated with helminth infection
18) Confidence 0.42 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0
As in humans, macaque memory B-cells can express CD80 and CD86 co-stimulatory molecules: most peripheral memory B-cells (SIgD?
Gene_expression (express) of CD80 in memory B-cells
19) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.31 Pain Relevance 0
While CD80 expression was consistent in each culture condition, CD83 expression was much more sensitive to the differing conditions.
Gene_expression (expression) of CD80
20) Confidence 0.38 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.40 Pain Relevance 0

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