INT93915

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 12.45
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
CD86 12
platelets 4
PDL-1 2
blood 2
endothelial cells 2
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 220 100.00 Very High Very High Very High
cytokine 69 100.00 Very High Very High Very High
tolerance 8 99.72 Very High Very High Very High
chemokine 41 98.80 Very High Very High Very High
rheumatoid arthritis 201 90.88 High High
Chronic pancreatitis 20 87.36 High High
Neuritis 2 86.60 High High
COX2 2 83.52 Quite High
Inflammatory response 9 81.64 Quite High
medulla 3 79.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 231 100.00 Very High Very High Very High
Adhesions 18 100.00 Very High Very High Very High
Adenocarcinoma 180 99.42 Very High Very High Very High
Hepatitis 2 98.32 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 97.68 Very High Very High Very High
Sepsis 49 97.52 Very High Very High Very High
Disease 74 96.92 Very High Very High Very High
Skin Diseases 2 93.20 High High
Infection 43 93.12 High High
Autoimmune Disease 7 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition they found the expression of CD40 to be increased.
Positive_regulation (increased) of Gene_expression (expression) of CD40
1) Confidence 0.44 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.08 Pain Relevance 0.15
Increased levels of pro-inflammatory cytokines (TNF and IL-6) and increased production of soluble CD40 ligand from activated platelets [15,16] are also thought to play an important role.
Positive_regulation (Increased) of Gene_expression (production) of CD40 in platelets associated with inflammation and cytokine
2) Confidence 0.42 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.54 Pain Relevance 0.19
The myeloid dendritic cells in CSF expressed higher levels of HLA-DR, CD86, CD80 and CD40 than those in blood, whereas expression of these molecules by plasmacytoid dendritic cells was equal in blood and CSF.
Positive_regulation (levels) of Gene_expression (expressed) of CD40 in blood
3) Confidence 0.39 Published 2001 Journal Brain Section Abstract Doc Link 11222448 Disease Relevance 1.01 Pain Relevance 0.43
We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR.
Positive_regulation (enhanced) of Gene_expression (expression) of CD40 in PDL-1 associated with adenocarcinoma
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 1.24 Pain Relevance 0.21
During these processes DCs undergo diverse phenotypical and functional changes such as reduced phagocytic ability, upregulated cell surface expression of co-stimulatory molecules and adhesion proteins, such as CD86, CD83, CD54, CD40, and MHC II antigens.
Positive_regulation (upregulated) of Gene_expression (expression) of CD40 in CD86 associated with adhesions
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.33 Pain Relevance 0.08
Both lipopolysaccharide (LPS) and proinflammatory cytokines induce the expression of CD40, vascular adhesion molecule-1 or intercellular adhesion molecule-1, and E-selectin on human brain microvessel endothelial cells [20-24].
Positive_regulation (induce) of Gene_expression (expression) of CD40 in endothelial cells associated with adhesions and cytokine
6) Confidence 0.29 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.84 Pain Relevance 0.33
Increased levels of pro-inflammatory cytokines (TNF and IL-6) and increased production of soluble CD40 ligand from activated platelets [15,16] are also thought to play an important role.
Positive_regulation (increased) of Gene_expression (production) of CD40 in platelets associated with inflammation and cytokine
7) Confidence 0.28 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.46 Pain Relevance 0.19
Translocation of RelB to the nucleus of myeloid DCs is associated with APC function, particularly through increased expression of MHC molecules CD86 and CD40 [26].
Positive_regulation (increased) of Gene_expression (expression) of CD40 in CD86
8) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.14 Pain Relevance 0.48
The loss of tolerance model due to CD40–CD40L activation signals
Positive_regulation (activation) of Gene_expression (signals) of CD40 associated with tolerance
9) Confidence 0.25 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.84 Pain Relevance 0.44
In addition, phlogogenic cytokines activate neutrophils to express CCR6, CD80, CD83, CD86, and CD40, an expression pattern that resembles a dendritic-like phenotype [10,11].
Positive_regulation (activate) of Gene_expression (express) of CD40 in CD86 associated with cytokine
10) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.21 Pain Relevance 0.55
Increased expression of costimulatory molecules, CD40 and CD86 [28] and changes in chemokine receptor expression was evident ex vivo on DCs isolated from HIV-1 infected individuals [29].
Positive_regulation (Increased) of Gene_expression (expression) of CD40 in CD86 associated with chemokine and acquired immune deficiency syndrome or hiv infection
11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.57 Pain Relevance 0.19
In this setting, HMB-PP-stimulated but not unstimulated co-cultures produced soluble factors that crossed the separating membrane and down-modulated CD14 as well as induced expression of CD40, CD86, and HLA-DR.
Positive_regulation (induced) of Gene_expression (expression) of CD40 in CD86
12) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.04
DCs maturation was evidenced by increased expression of CD83, CD80, CD86, HLA class I and II and CD40.
Positive_regulation (increased) of Gene_expression (expression) of CD40 in CD86
13) Confidence 0.18 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.18 Pain Relevance 0.05
B1 p50 oligonucleotide to HUVEC caused only a very small inhibition of the TNF-?
Positive_regulation (caused) of Gene_expression (oligonucleotide) of p50
14) Confidence 0.14 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0.03

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