INT93918

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 0.89
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Amph) cytoplasm (Amph)
Anatomy Link Frequency
striatum 3
blood 1
plasma 1
Amph (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 731 100.00 Very High Very High Very High
amygdala 3 94.16 High High
Serotonin 3 93.20 High High
imagery 35 88.64 High High
Ventral tegmentum 21 77.52 Quite High
tetrodotoxin 1 69.60 Quite High
Nucleus accumbens 7 66.56 Quite High
Glutamate 1 53.04 Quite High
addiction 14 52.24 Quite High
Neurotransmitter 14 38.80 Quite Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 2 99.96 Very High Very High Very High
Hyperglycemia 7 97.92 Very High Very High Very High
Congenital Anomalies 7 96.00 Very High Very High Very High
Fever 5 86.92 High High
Convulsion 3 81.00 Quite High
Attention Deficit Hyperactivity Disorder 9 60.08 Quite High
Drug Dependence 14 52.64 Quite High
Diabetes Mellitus 42 46.96 Quite Low
Amphetamine Dependence 7 25.00 Low Low
Decapitation 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies are necessary to determine the impact of these differences in release on AMPH neurotoxicity.
Localization (release) of AMPH associated with drug induced neurotoxicity
1) Confidence 0.62 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11222877 Disease Relevance 0.48 Pain Relevance 0.50
It is possible that factors other than PI3K signaling (e.g., altered blood glucose levels) might contribute to the blunted AMPH-induced DA release caused by STZ treatment.
Localization (release) of AMPH-induced in blood associated with dopamine
2) Confidence 0.53 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.55
Importantly, others have reported decreases in AMPH-induced DA release in NAc dialysates collected in freely moving rats [65].
Localization (release) of AMPH-induced associated with dopamine
3) Confidence 0.53 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.17 Pain Relevance 0.21
Figure 3 shows the effect of LY294002 pretreatment on AMPH-induced DA release.
Localization (release) of AMPH-induced associated with dopamine
4) Confidence 0.53 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.44
Therefore, it is conceivable that PI3K signaling and ultimately Akt, by fine-tuning DAT expression at the plasma membrane [13,29], regulate the ability of AMPH to cause DAT-mediated DA efflux.
Localization (cause) of AMPH in plasma associated with dopamine
5) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.32
Because hyperglycemia has been shown to not significantly influence BOLD signals [66], our data suggest that blunting of the AMPH-induced BOLD response in the DAT-dense striatum of insulin-depleted rats (Figure 5) is not due to STZ-mediated metabolic abnormalities.
Localization (response) of AMPH-induced in striatum associated with hyperglycemia and congenital anomalies
6) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.19 Pain Relevance 0.22
Finally, local infusion of insulin into the striatum of STZ-treated animals significantly recovers the ability of AMPH to stimulate DA release as measured by high-speed chronoamperometry.
Localization (release) of AMPH in striatum associated with dopamine
7) Confidence 0.49 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.21
To further elucidate the links between the PI3K signaling pathway, DAT function and AMPH action, we activated the PI3K pathway pharmacologically within the striatum of STZ-treated, hypoinsulinemic animals by locally infusing insulin just before the delivery of a brief AMPH pulse in this region.
Localization (pulse) of AMPH in striatum
8) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.05 Pain Relevance 0.28

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