INT93926

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ece1) peptidase activity (Ece1) Golgi apparatus (Ece1)
plasma membrane (Ece1)
Anatomy Link Frequency
myocardium 1
Ece1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 92.76 High High
Inflammation 16 90.80 High High
cytokine 10 84.36 Quite High
Inflammatory response 2 71.04 Quite High
fibrosis 20 52.24 Quite High
imagery 1 43.68 Quite Low
ischemia 6 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 99.18 Very High Very High Very High
Sprains And Strains 11 98.60 Very High Very High Very High
Disease 76 97.80 Very High Very High Very High
Infection 26 97.06 Very High Very High Very High
Natriuresis 1 93.80 High High
Heart Disease 12 92.64 High High
INFLAMMATION 16 90.80 High High
Cognitive Disorder 3 86.44 High High
Adhesions 4 85.16 High High
Chagas Cardiomyopathy 34 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
peptide, NEP [14], IDE [15], plasmin [33], and endothelin converting enzyme (ECE-1) [34] originate from a variety of cell types, degrade A?
Gene_expression (peptide) of endothelin converting enzyme
1) Confidence 0.27 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.74 Pain Relevance 0
The infection of CD1 mice with the Brazil strain and C57BL/6 mice with the Tulahuen strain caused an intense vasculitis, high plasma ET-1 levels, and increased expression of mRNAs for the precursor molecule preproET-1, endothelin converting enzyme (ECE), and ET-1 in the myocardium [76].
Gene_expression (expression) of endothelin converting enzyme in myocardium associated with increased venous pressure under development, sprains and strains and infection
2) Confidence 0.12 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 1.31 Pain Relevance 0.24
Other related mammalian NEP-like enzymes include the endothelin-converting enzymes (ECE-1 and ECE-2), KELL and PEX.
Gene_expression (include) of ECE-1
3) Confidence 0.07 Published 2001 Journal Bioessays Section Abstract Doc Link 11223883 Disease Relevance 0.27 Pain Relevance 0.18

General Comments

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