INT93936

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 3.43
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp) carbohydrate metabolic process (Pgp) molecular_function (Pgp)
cellular_component (Pgp)
Anatomy Link Frequency
nerve 2
brain 2
epidermis 1
Pgp (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 168 100.00 Very High Very High Very High
antidepressant 6 99.70 Very High Very High Very High
Opioid 13 99.56 Very High Very High Very High
Morphine 25 98.68 Very High Very High Very High
analgesia 2 98.32 Very High Very High Very High
Bioavailability 40 97.36 Very High Very High Very High
tolerance 21 97.36 Very High Very High Very High
dorsal root ganglion 108 97.24 Very High Very High Very High
Analgesic 1 96.16 Very High Very High Very High
Neurotransmitter 6 89.84 High High
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 15 99.76 Very High Very High Very High
Ganglion Cysts 111 97.24 Very High Very High Very High
Disease 47 96.52 Very High Very High Very High
Death 15 96.28 Very High Very High Very High
Apoptosis 40 95.84 Very High Very High Very High
Inflammatory Bowel Disease 5 94.88 High High
Cancer 114 92.16 High High
Increased Venous Pressure Under Development 14 89.72 High High
Primary Sclerosing Cholangitis 15 87.88 High High
Hypoxia 12 84.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
St John's Wort used as an antidepressant increases the expression of Pgp, so it could significantly lower the serum concentration of indinavir or cyclosporin [166].
Gene_expression (expression) of Pgp associated with antidepressant
1) Confidence 0.59 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.25 Pain Relevance 0.18
On the contrary, some drugs could increase the expression of Pgp.
Gene_expression (expression) of Pgp
2) Confidence 0.59 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.27 Pain Relevance 0.18
Lowering Pgp expression significantly enhanced systemic morphine analgesia and prevented tolerance, but diminished the analgesic activity of centrally administered morphine, implying that supraspinal analgesia resulted from a combination of central and peripheral mechanisms activated by morphine transported from the brain to the blood.
Gene_expression (expression) of Pgp in brain associated with analgesic, tolerance, analgesia and morphine
3) Confidence 0.57 Published 2001 Journal Nat. Neurosci. Section Abstract Doc Link 11224543 Disease Relevance 0 Pain Relevance 1.10
MDR1 polymorphism could be not only associated with alteration of Pgp expression and/or function, drug disposition and treatment outcome but also increase the risk of diseases such as Parkinson's disease and ulcerative colitis [159].
Gene_expression (expression) of Pgp associated with inflammatory bowel disease and disease
4) Confidence 0.51 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.48 Pain Relevance 0.18
Overexpression of ABC transporters such as Pgp, MRP and BCRP has been shown to be responsible for the major portion of MDR.
Gene_expression (Overexpression) of Pgp
5) Confidence 0.45 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.31 Pain Relevance 0
Pgp is mainly present in the apical membrane of intestinal mucosal membrane and lowers bioavailability of drugs by preventing the absorption of the drugs.
Gene_expression (present) of Pgp associated with bioavailability
6) Confidence 0.45 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.38 Pain Relevance 0.20
A recent study reported a decrease in the expression of cerebovascular Pgp in a CJD patient, suggesting a possible role for Pgp in prion pathogenesis [25].
Gene_expression (expression) of Pgp associated with creutzfeldt jakob disease
7) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.10 Pain Relevance 0
Binding in the brain, measured by Vu,brain, was not different and the cetirizine enantiomers had similar Kp,uu values, indicating that Pgp in the BBB handles the enantiomers similarly.
Gene_expression (handles) of Pgp in brain
8) Confidence 0.18 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.37
Overexpression of Pgp, MDR-associated-protein 1 (MRP1/ABCC1) or ABCG2 has been positively correlated with the evolution of MDR as well as cross-resistance to structurally unrelated anti-neoplastic drugs in a clinical tumor burden [96].
Gene_expression (Overexpression) of Pgp associated with cancer
9) Confidence 0.07 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.73 Pain Relevance 0.04
In the small nerve bundles of PGP 9.5-positive fibers within dermis immediately subjacent to epidermis, NaV1.1 labeling was not detectable (Figure 5), consistent with limited NaV1.1 expression that has been reported within small DRG neurons [20].
Gene_expression (bundles) of PGP in epidermis associated with dorsal root ganglion
10) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.39 Pain Relevance 0.32
As anticipated, NaV1.1 immunolabeling was not detectable in the PGP 9.5-positive free nerve endings (Figure 6).
Neg (not) Gene_expression (detectable) of PGP in nerve
11) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.42 Pain Relevance 0.25
For assessment of the percentage of free nerve endings expressing NCX2 or sodium channel isoforms, PGP 9.5-positive free nerve endings were identified (blindly with respect to the sodium channel/NCX2 immunosignal) with the green channel and then the sodium channel or NCX2 labeling was visualized in the red channel.
Gene_expression (expressing) of PGP in nerve associated with sodium channel
12) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.11 Pain Relevance 0.23

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