INT93941

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 5.32
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SCP 1
nerve 1
SSX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 94.72 High High
pain flank 1 46.40 Quite Low
Sciatica 6 10.00 Low Low
Neuritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Testicular Cancer 20 100.00 Very High Very High Very High
Pancreatic Cancer 10 99.90 Very High Very High Very High
Synovial Sarcoma 42 98.48 Very High Very High Very High
Cancer 13 98.32 Very High Very High Very High
Solid Tumor 1 97.44 Very High Very High Very High
Melanoma 2 96.28 Very High Very High Very High
Lymphatic System Cancer 1 95.84 Very High Very High Very High
Leukemia 3 95.40 Very High Very High Very High
Adenocarcinoma 4 95.12 Very High Very High Very High
Pancreatitis 10 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The molecular assay of the detection of the SYT/SSX fusion gene is useful to make a definite diagnosis of monophasic synovial sarcoma.


Gene_expression (detection) of SSX
1) Confidence 0.75 Published 2001 Journal Spine Section Body Doc Link 11224869 Disease Relevance 0 Pain Relevance 0
SYT-SSX2 transcripts were detected in all 3 cases.
Gene_expression (detected) of SSX2
2) Confidence 0.65 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 15105652 Disease Relevance 1.01 Pain Relevance 0
have shown that the SYT partner of the SYT-SSX fusion oncoprotein interacts
Gene_expression (partner) of SSX
3) Confidence 0.65 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.03 Pain Relevance 0
The authors diagnosed the tumor arising within the S1 nerve root as synovial sarcoma using cytogenetic analysis that detected the chimeric SYT/SSX gene.
Gene_expression (detected) of SSX in nerve
4) Confidence 0.58 Published 2001 Journal Spine Section Body Doc Link 11224869 Disease Relevance 0 Pain Relevance 0
While all CT genes were frequently expressed in cell lines derived from pancreatic cancer, no expression of MAGE-3, SSX-1, SSX-2, NY-ESO-1 and CT-7 was detected in fresh tumor biopsies, and MAGE-4 (1/52), SSX-4 (1/39) and CT-8 (2/41) were only rarely expressed.
Gene_expression (expression) of SSX-2 associated with cancer, pancreatic cancer and testicular cancer
5) Confidence 0.48 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.78 Pain Relevance 0.28
In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines.
Spec (investigated) Gene_expression (expression) of SSX-2 in SCP associated with adenocarcinoma, pancreatic cancer, testicular cancer and chronic pancreatitis
6) Confidence 0.48 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.51 Pain Relevance 0.17

General Comments

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