INT93947

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 5.04
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
cartilage 4
TMJ 4
platelet 2
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 83 100.00 Very High Very High Very High
cINOD 3 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
rheumatoid arthritis 79 99.88 Very High Very High Very High
Snapping jaw 12 99.84 Very High Very High Very High
cytokine 25 99.62 Very High Very High Very High
Angina 1 99.00 Very High Very High Very High
Arthritis 49 97.76 Very High Very High Very High
Osteoarthritis 4 94.96 High High
Inflammation 25 88.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 20 100.00 Very High Very High Very High
Hypoxia 18 100.00 Very High Very High Very High
Thrombosis 1 100.00 Very High Very High Very High
Stroke 1 99.90 Very High Very High Very High
Rheumatoid Arthritis 79 99.88 Very High Very High Very High
Temporomandibular Joint Syndrome 12 99.84 Very High Very High Very High
Myocardial Infarction 1 99.66 Very High Very High Very High
Cv General 3 Under Development 1 99.00 Very High Very High Very High
Acute Coronary Syndrome 1 98.52 Very High Very High Very High
Arthritis 52 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced MMP production by RA FLS, altered the MMP/TIMP balance in favour of cartilage protection ex vivo, modulated synovial IL-1?
Regulation (altered) of Gene_expression (balance) of TIMP in cartilage associated with rheumatoid arthritis and metalloproteinase
1) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.00 Pain Relevance 0.72
The NFkappaB pathway is important in the control of cytokine synthesis and can modulate production of chemokines, matrix metalloproteinases and the inducible prostaglandin synthesis enzyme COX-2.
Regulation (modulate) of Gene_expression (production) of metalloproteinases associated with chemokine, metalloproteinase and cytokine
2) Confidence 0.01 Published 2001 Journal Reproduction Section Abstract Doc Link 11226025 Disease Relevance 0.26 Pain Relevance 0.50
Studies suggested a crucial role of cAMP on the development of acute coronary syndromes [(ACS); unstable angina, and acute myocardial infarction] and stroke, by modulating platelet aggregation and thrombus formation and the expression of metalloproteinases.
Regulation (modulating) of Gene_expression (expression) of metalloproteinases in platelet associated with acute coronary syndrome, angina, stroke, metalloproteinase, thrombosis and myocardial infarction
3) Confidence 0.00 Published 2010 Journal Curr Vasc Pharmacol Section Abstract Doc Link 19485905 Disease Relevance 1.15 Pain Relevance 0.23
The aim of this pilot clinical study was to examine the effects of a nonsteroidal anti-inflammatory drug, nimesulide, on the synthesis of matrix metalloproteinases (MMPs) which are important enzymes in cartilage proteolysis.
Spec (examine) Regulation (effects) of Gene_expression (synthesis) of metalloproteinases in cartilage associated with inflammation, metalloproteinase and cinod
4) Confidence 0.00 Published 2002 Journal Int J Clin Pract Suppl Section Abstract Doc Link 12166616 Disease Relevance 0.58 Pain Relevance 0.57
Role of hypoxia and interleukin-1beta in gene expressions of matrix metalloproteinases in temporomandibular joint disc cells.
Regulation (Role) of Gene_expression (expressions) of metalloproteinases in temporomandibular joint associated with snapping jaw, hypoxia and metalloproteinase
5) Confidence 0.00 Published 2005 Journal Arch. Oral Biol. Section Title Doc Link 15598420 Disease Relevance 1.14 Pain Relevance 0.73
The aim of this study was to test the hypothesis that hypoxia and interleukin-1 (IL-1)beta played a substantial role in gene expressions of matrix metalloproteinases (MMPs) in temporomandibular joint (TMJ) disc cells.
Regulation (role) of Gene_expression (expressions) of metalloproteinases in TMJ associated with snapping jaw, hypoxia and metalloproteinase
6) Confidence 0.00 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 15598420 Disease Relevance 0.91 Pain Relevance 0.67

General Comments

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