INT93948

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 48
Total Number 50
Disease Relevance 27.77
Pain Relevance 16.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 16
dendritic cells 6
bone marrow 2
nucleus 2
Spleen 2
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 955 100.00 Very High Very High Very High
agonist 305 100.00 Very High Very High Very High
Pain 30 99.92 Very High Very High Very High
psoriasis 78 99.80 Very High Very High Very High
withdrawal 26 99.80 Very High Very High Very High
Morphine 43 99.70 Very High Very High Very High
antagonist 92 99.68 Very High Very High Very High
Inflammatory response 61 99.20 Very High Very High Very High
Delta-9-tetrahydrocannabinol 9 98.90 Very High Very High Very High
Cannabinoid receptor 4 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 755 100.00 Very High Very High Very High
Weight Loss 10 100.00 Very High Very High Very High
Pain 27 99.92 Very High Very High Very High
Psoriasis 102 99.80 Very High Very High Very High
Apoptosis 82 99.56 Very High Very High Very High
Hypersensitivity 73 99.36 Very High Very High Very High
Infection 973 99.30 Very High Very High Very High
Toxicity 37 99.18 Very High Very High Very High
INFLAMMATION 681 99.02 Very High Very High Very High
Osteoporosis 40 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Damgo and U-50488 at the concentrations of 10(-6) and 10(-8) M decreased the production of IL-12 without affecting IL-10.
Negative_regulation (decreased) of Gene_expression (production) of IL-12
1) Confidence 0.55 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.72
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.


Spec (whether) Negative_regulation (reduced) of Gene_expression (expression) of IL-12 in keratinocytes associated with psoriasis and apoptosis
2) Confidence 0.51 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.54 Pain Relevance 0.21
However, a mild toxicity was observed in mice treated with plant-expressed IL-12 as well as recombinant IL-12, according to a slight weight loss in both treatments (data not shown).
Negative_regulation (loss) of Gene_expression (expressed) of IL-12 associated with toxicity and weight loss
3) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.55 Pain Relevance 0.04
These results suggest that THC-induced suppression of serum IL-12 is partly due to a suppression of IL-12 production by dendritic cells and that G(i) signaling and cannabinoid receptors, but not TRPV1, are involved in this suppressive effect.
Negative_regulation (suppression) of Gene_expression (production) of IL-12 in dendritic cells associated with cannabinoid receptor and delta-9-tetrahydrocannabinol
4) Confidence 0.40 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.24 Pain Relevance 0.84
Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists.
Negative_regulation (Stimulation) of Gene_expression (production) of interleukin-12 in macrophages associated with agonist
5) Confidence 0.39 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.41
Yohimbine and 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)4,5-dihydro-1H-imidazole (RX821002), alpha(2)-adrenoceptor antagonists, significantly blocked agonist-induced interleukin-12 production and p38 MAPK activation, indicating that the effects of the agonists were mediated through alpha(2)-adrenoceptor.
Negative_regulation (blocked) of Gene_expression (production) of interleukin-12 associated with antagonist and agonist
6) Confidence 0.39 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.64
In addition, protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and chelerythrine, significantly inhibited guanfacine-induced interleukin-12 production and p38 MAPK in a concentration-dependent manner.
Negative_regulation (inhibited) of Gene_expression (production) of interleukin-12 associated with kinase c
7) Confidence 0.39 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.60
However, a mild toxicity was observed in mice treated with plant-expressed IL-12 as well as recombinant IL-12, according to a slight weight loss in both treatments (data not shown).
Negative_regulation (loss) of Gene_expression (expressed) of IL-12 associated with toxicity and weight loss
8) Confidence 0.37 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.55 Pain Relevance 0.04
They also exhibited impaired IL-12 expression and did not produce IL-10 after LPS stimulation.
Negative_regulation (impaired) of Gene_expression (expression) of IL-12
9) Confidence 0.29 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.13 Pain Relevance 0.41
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of Gene_expression (levels) of IL-12 in Spleen associated with withdrawal
10) Confidence 0.28 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.50
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Negative_regulation (decreased) of Gene_expression (production) of IL-12 in nucleus
11) Confidence 0.27 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.75
In HSV corneal infections in KO mice, IL-12 was shown to participate in the immune pathogenesis [393], but in another study utilizing IL-12 encoding plasmid DNA, corneal expression of IL-12 reduced the angiogenesis, and thus the pathology of the infection [394].
Negative_regulation (reduced) of Gene_expression (expression) of IL-12 associated with cold sores and infection
12) Confidence 0.22 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.73 Pain Relevance 0
Phagocytosis of apoptotic cells by macrophages inhibits production of IL-12, a regulatory mechanism which seems to be important in restriction of the damages induced by uncontrolled defence mechanisms [254].
Negative_regulation (inhibits) of Gene_expression (production) of IL-12 in macrophages associated with apoptosis
13) Confidence 0.22 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.34 Pain Relevance 0.24
Among these IL-10 holds a crucial position as an inhibitor of IL-12 production, an effect which is also conducted by transforming growth factor-?
Negative_regulation (inhibitor) of Gene_expression (production) of IL-12
14) Confidence 0.22 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.17 Pain Relevance 0.24
They also exhibited impaired IL-12 expression and did not produce IL-10 after LPS stimulation.
Negative_regulation (exhibited) of Gene_expression (expression) of IL-12
15) Confidence 0.21 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.14 Pain Relevance 0.44
Inhibitors of IL-12 gene expression, including retinoids, acetyl
Negative_regulation (Inhibitors) of Gene_expression (expression) of IL-12
16) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.20 Pain Relevance 0.34
Therefore, it was the aim of the current studies to develop an in vitro model to examine the process of morphine withdrawal and to understand the signaling mechanisms that withdrawal may use to effect IL-12 production through the use of this model.
Negative_regulation (effect) of Gene_expression (production) of IL-12 associated with withdrawal and morphine
17) Confidence 0.20 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.90
Many individuals with genetic defects of IL-12/23-IFN-?
Negative_regulation (defects) of Gene_expression (/) of IL-12
18) Confidence 0.18 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.77 Pain Relevance 0.17
agonist 15d-PGJ2 inhibits production of IL-12 and
Negative_regulation (inhibits) of Gene_expression (production) of IL-12 associated with agonist
19) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.64 Pain Relevance 0.33
Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice.
Negative_regulation (reduced) of Gene_expression (production) of IL-12 in macrophage associated with cytokine and morphine
20) Confidence 0.16 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.18 Pain Relevance 0.95

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