INT93951

Context Info Confidence 0.00 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.51

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1) nucleus (Nfkb1)

Nfkb1 (Mus musculus) Timp1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 9 100.00 chemokine 2 100.00 metalloproteinase 1 100.00 Inflammation 1 71.60 Dismenorea 1 63.76 cINOD 2 60.40 Inflammatory response 1 45.44

Disease Link Frequency Relevance Heat INFLAMMATION 4 71.60 Reprotox - General 1 2 65.04 Targeted Disruption 2 25.00 Leukemia 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The NFkappaB pathway is important in the control of cytokine synthesis and can modulate production of chemokines, matrix metalloproteinases and the inducible prostaglandin synthesis enzyme COX-2.

NFkappaB Regulation (modulate) of Gene_expression (production) of metalloproteinases associated with chemokine, metalloproteinase and cytokine

1) Confidence 0.00 Published 2001 Journal Reproduction Section Abstract Doc Link 11226025 Disease Relevance 0.26 Pain Relevance 0.51

General Comments

This test has worked.