INT93956

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 8.86
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HBM)
Anatomy Link Frequency
plasma 2
erythrocytes 1
lymphocyte 1
brain 1
urine 1
HBM (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 4 99.12 Very High Very High Very High
antagonist 51 98.60 Very High Very High Very High
ischemia 31 93.24 High High
Pain 193 82.44 Quite High
headache 11 77.96 Quite High
palliative 2 70.84 Quite High
Lasting pain 4 70.16 Quite High
cva 47 66.32 Quite High
Serotonin 2 64.80 Quite High
cytokine 38 63.28 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 76 99.84 Very High Very High Very High
Tricuspid Valve Insufficiency 51 99.76 Very High Very High Very High
Myoglobinuria 4 99.24 Very High Very High Very High
Hemolysis 12 98.66 Very High Very High Very High
Obesity 41 98.00 Very High Very High Very High
Injury 97 96.88 Very High Very High Very High
Sickle Cell Anemia 66 96.88 Very High Very High Very High
Hemorrhagic Shock 48 96.60 Very High Very High Very High
Renal Failure 16 95.80 Very High Very High Very High
Hypertension 28 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diaspirin cross-linked hemoglobin (DCLHb), administered at doses ranging from approximately 20-1000 ml, has been investigated in a number of clinical trials in patients undergoing orthopedic, abdominal aortic repair, major abdominal surgery, cardiac surgery and in critically ill patients with septic shock.
hemoglobin Binding (linked) of associated with critical illness and sepsis
1) Confidence 0.35 Published 1999 Journal Crit Care Section Abstract Doc Link PMC137240 Disease Relevance 0.33 Pain Relevance 0.05
AWT, TKG, and CLH conceived the study design, TKG conducted the statistical analysis, HBM and CLH interpreted the results, HBM drafted the manuscript, and all authors read and approved the final manuscript.



HBM Binding (interpreted) of
2) Confidence 0.35 Published 2008 Journal J Foot Ankle Res Section Body Doc Link PMC2553780 Disease Relevance 0.22 Pain Relevance 0.14
CLH, TKG and AWT conceived the study design, TKG conducted the statistical analysis, CLH and HBM interpreted the results and drafted the manuscript, and all authors read and approved the final manuscript.



HBM Binding (interpreted) of
3) Confidence 0.35 Published 2008 Journal J Foot Ankle Res Section Body Doc Link PMC2547889 Disease Relevance 0.60 Pain Relevance 0.49
The Cronbach’s alpha coefficients for the HBM categories were: perceived susceptibility (HBM1) ?
HBM1 Binding (susceptibility) of
4) Confidence 0.34 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872324 Disease Relevance 0 Pain Relevance 0
Calculating Pearson's correlation coefficient, a significant, positive association was found between the benefit component of the HBM and prisoners not engaging in HIV high-risk behaviors.


HBM Binding (engaging) of associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.31 Published 2008 Journal Harm Reduct J Section Abstract Doc Link PMC2443130 Disease Relevance 0.51 Pain Relevance 0
When hemoglobin is within the red blood cells, NO is removed as it dissolves into the plasma and ultimately interacts with hemoglobin.
hemoglobin Binding (interacts) of in plasma
6) Confidence 0.14 Published 1997 Journal Crit Care Section Body Doc Link PMC28996 Disease Relevance 0.67 Pain Relevance 0
Hemoglobin affinity for oxygen is altered by pH, temperature, and high altitude, making oxygen more readily available to the tissues.
Hemoglobin Binding (affinity) of
7) Confidence 0.05 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11226087 Disease Relevance 0 Pain Relevance 0.05
Reductions in hemoglobin, with decreases from baseline, occurred more often in the group receiving bosentan plus dacarbazine than the group receiving placebo plus dacarbazine: hemoglobin decreased to >8 and ?
hemoglobin Binding (occurred) of
8) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2856553 Disease Relevance 0.44 Pain Relevance 0
Hemoglobin oxygen saturation did not have a significant independent association with tricuspid regurgitation velocity after adjustment for the hemolytic component, VEGF, PDGF and interleukin-6 in the logistic regression model.
Hemoglobin Binding (association) of associated with tricuspid valve insufficiency
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 0.45 Pain Relevance 0
The resultant decrease in affinity of hemoglobin for oxygen makes more O2 available to the tissues.[21]

Tissue changes

hemoglobin Binding (affinity) of
10) Confidence 0.02 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 0.48 Pain Relevance 0
ACE: Angiotensin converting enzyme; Ang II: plasma concentration of angiotensin II; EDTA: ethylenediaminetetraacetate; NIRS: near infrared spectroscopy; PRA: plasma renin activity; RAS: Renin-Angiotensin System; RIA: radioimmune assay; SOFA: Sequential Organ Failure Assessment score; SpO2: percent oxygen saturation of arterial hemoglobin: as measured with pulse oximetry; StO2: percent oxygen saturation of microvascular (tissue) hemoglobin: as measured with NIRS.


hemoglobin Binding (saturation) of in plasma
11) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.58 Pain Relevance 0.08
With regard to bivariate and multivariate analyses, the linear correlation indicated that survival was associated with albumin (r = 0.489, P = 0.001) and hemoglobin (r = 0.300, P = 0.008) but not with age, weight, BMI, lymphocyte count, or cholesterol [84].
hemoglobin Binding (associated) of in lymphocyte associated with obesity
12) Confidence 0.02 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.07 Pain Relevance 0.15
It binds oxygen with an affinity between that of myoglobin and hemoglobin [3,4].
hemoglobin Binding (binds) of
13) Confidence 0.02 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.30 Pain Relevance 0.10
It is possible that hemoglobin modulates the behavior of canids by interaction with CO and NO signaling.
hemoglobin Neg (NO) Binding (interaction) of
14) Confidence 0.01 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1858698 Disease Relevance 0.05 Pain Relevance 0
Second, besides the well known role as an oxygen transport molecule, hemoglobin also binds carbon monoxide (CO) and nitric oxide (NO) with high affinity, and acts as an extra-cellular scavenger of these signaling molecules in the mammalian brain [20].
hemoglobin Binding (binds) of in brain
15) Confidence 0.01 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.21 Pain Relevance 0.03
In perhaps, the most extensive investigation of the phenomenon to date, Sabbioni (36) tested 32 compounds in rats for their ability to bind to hemoglobin in a manner that is demonstrative of the generation of N-hydroxylamines in vivo.
hemoglobin Binding (bind) of
16) Confidence 0.01 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0
Surprisingly, an interim analysis of clinical application of the long-term favorite HBOC diaspirin-crosslinked hemoglobin (HemAssist™; Baxter Healthcare, Round Lake, IL, USA) for treatment of severe trauma-hemorrhagic shock [115] demonstrated increased rates of 24-hour and 48-hour mortality; therefore, the trauma study was discontinued.
hemoglobin Binding (crosslinked) of associated with injury and hemorrhagic shock
17) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 1.03 Pain Relevance 0.11
Decreases in hemoglobin concentration have also been recognized as a class effect associated with ERAs (Galie et al 2005a).
hemoglobin Binding (recognized) of associated with antagonist
18) Confidence 0.01 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.11 Pain Relevance 0.05
Hemolysis causes the release of hemoglobin from erythrocytes, and this free hemoglobin binds with NO, reducing NO bioavailability and resulting in the formation of reactive oxygen species, which are potentially damaging to the pulmonary vasculature.
hemoglobin Neg (NO) Binding (binds) of in erythrocytes associated with hemolysis and bioavailability
19) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.73 Pain Relevance 0.23
A urine dipstick is a quick way to screen for myoglobinuria, as the reagent on the dipstick that reacts with hemoglobin also reacts with myoglobin [18].
hemoglobin Binding (reacts) of in urine associated with myoglobinuria
20) Confidence 0.00 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 1.07 Pain Relevance 0

General Comments

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