INT93967

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 6.81
Pain Relevance 10.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
substantia nigra pars compacta 3
striatum 2
substantia nigra 1
brain 1
synapse 1
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1145 100.00 Very High Very High Very High
midbrain 36 99.98 Very High Very High Very High
cocaine 566 99.74 Very High Very High Very High
fluoxetine 19 99.30 Very High Very High Very High
Endep 8 98.90 Very High Very High Very High
Substantia nigra 28 98.72 Very High Very High Very High
dopamine receptor 21 96.40 Very High Very High Very High
monoamine 55 95.28 Very High Very High Very High
Nucleus accumbens 56 94.24 High High
addiction 14 94.16 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 237 99.80 Very High Very High Very High
Clinical Trials And Case Reports 6 99.52 Very High Very High Very High
Targeted Disruption 59 97.52 Very High Very High Very High
Drug Dependence 16 94.80 High High
Manic Depressive Disorder 8 92.72 High High
Alcohol Addiction 4 90.88 High High
Parkinson's Disease 74 86.28 High High
Catalepsy 8 84.48 Quite High
Tremor 21 83.52 Quite High
Ocular Toxicity (including Many Sub-types) 29 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, cocaine elevates extracellular DA by simply binding to DAT and inhibiting DA reuptake.
DAT Binding (binding) of associated with dopamine and cocaine
1) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.19 Pain Relevance 0.77
Cook [48] summarized the results of an additional 11 family-based studies in a meta analysis and concluded that the association between the DAT gene and ADHD was highly significant (p < .0001).
DAT gene Binding (association) of associated with attention deficit hyperactivity disorder and clinical trials and case reports
2) Confidence 0.40 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.69 Pain Relevance 0.51
Amitriptyline, but not fluoxetine, increased striatal [3H]GBR 12935 binding to the dopamine transporter, whereas its mRNA level in the substantia nigra pars compacta was decreased in fluoxetine, compared to vehicle- or amitriptyline-treated transgenic mice.
dopamine transporter Binding (binding) of in substantia nigra pars compacta associated with targeted disruption, dopamine, substantia nigra, endep and fluoxetine
3) Confidence 0.39 Published 2001 Journal Neuroscience Section Abstract Doc Link 11226678 Disease Relevance 0.56 Pain Relevance 0.93
The DAT-KO and DAT-CI mice were generated using ES cells from 129Sv/J mice and crossed with C57BL6 mice, thus they have a mixed genetic background [17].
DAT-KO Binding (crossed) of
4) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.20 Pain Relevance 0.42
The DAT-KO and DAT-CI mice were generated using ES cells from 129Sv/J mice and crossed with C57BL6 mice, thus they have a mixed genetic background [17].
DAT-CI Binding (crossed) of
5) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.20 Pain Relevance 0.42
In contrast, in homozygous DAT-KO mice DAT is completely lacking.
DAT Binding (lacking) of
6) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.52
In contrast, in homozygous DAT-KO mice DAT is completely lacking.
DAT-KO Binding (lacking) of
7) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.52
Tamoxifen at 50 microg reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mRNA levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mRNA levels.
dopamine transporter Binding (binding) of in substantia nigra associated with dopamine and substantia nigra
8) Confidence 0.36 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17825264 Disease Relevance 0.22 Pain Relevance 0.61
Subjects homozygous for the 10-repeat allele showed significantly lower dopamine transporter binding than carriers of the 9-repeat allele [47].
dopamine transporter Binding (binding) of associated with dopamine
9) Confidence 0.35 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.73 Pain Relevance 0.40
The interaction of psychostimulating drugs with the DAT is thought to be critically important for many of the actions of these drugs, including the reward and locomotor stimulating effects.
DAT Binding (interaction) of
10) Confidence 0.35 Published 2004 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 15765018 Disease Relevance 0.27 Pain Relevance 0.55
Only E was able to prevent loss of DAT binding in the lateral striatum and to attenuate the MA-induced increase in striatal PPE mRNA levels (at 1 or 40 microg).
DAT Binding (binding) of in striatum
11) Confidence 0.35 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16446547 Disease Relevance 0.21 Pain Relevance 0.27
Binding to DAT was unchanged throughout brain.
DAT Binding (Binding) of in brain
12) Confidence 0.34 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 18406571 Disease Relevance 0.22 Pain Relevance 0.74
To minimize interference with DAT function by preservation of both DAT alleles, Cre recombinase expression was driven from the 3?
DAT Binding (minimize) of
13) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.16 Pain Relevance 0.25
Amphetamine is known to increase dopamine (DA) release by acting directly on dopamine transporters (DAT), primarily through a mechanism that is independent of impulse flow.
DAT Binding (acting) of associated with dopamine
14) Confidence 0.31 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15056292 Disease Relevance 0 Pain Relevance 0.54
It is commonly believed that the reinforcing properties of cocaine depend upon interaction with the DAT, however, cocaine is still reinforcing in mice with a genetic deletion of the DAT (DAT-KO mice).
DAT Binding (interaction) of associated with cocaine
15) Confidence 0.31 Published 2004 Journal J. Neurosci. Methods Section Abstract Doc Link 15589348 Disease Relevance 0 Pain Relevance 0.96
The DA-depleted DAT-KO mice (DDD mice) become akinetic almost immediately after treatment, in contrast to the essentially normal motor function displayed by ?
DAT-KO Binding (-) of associated with dopamine
16) Confidence 0.30 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.34 Pain Relevance 0.45
In contrast, autoradiography of striatal [3H]GBR 12935 binding to the dopamine transporter was decreased and the mRNA levels of this transporter, measured by in situ hybridization, remained unchanged in the substantia nigra pars compacta.
dopamine transporter Binding (binding) of in substantia nigra pars compacta associated with dopamine and substantia nigra
17) Confidence 0.29 Published 2001 Journal Neuroscience Section Abstract Doc Link 11226678 Disease Relevance 0.48 Pain Relevance 0.62
It has been recently reported that the mixed DAT and NET inhibitor nomifensine can also potently activate TA1 receptor whereas the selective DAT blocker GBR12909 completely lacks the ability to interact with TA1 receptor [42].
DAT Binding (interact) of
18) Confidence 0.29 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.08 Pain Relevance 0.09
Moreover, inheritance and allelic variant studies show an
   association between DAT, the dopamine transporter gene which is involved in
   transporting dopamine back into the neuron after it has been released into the synapse, and ADHD
    40, 50. 
DAT Binding (association) of in synapse associated with dopamine and attention deficit hyperactivity disorder
19) Confidence 0.21 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 1.11 Pain Relevance 0.20
The scale correlated with the striatal volume reduction (r(2)=0.57) and striatal cell loss (r(2)=0.87) but not with the loss of striatal dopaminergic terminals (dopamine transporter binding).
dopamine transporter Binding (binding) of associated with dopamine
20) Confidence 0.16 Published 2002 Journal Neuroscience Section Abstract Doc Link 12379255 Disease Relevance 0.27 Pain Relevance 0.25

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