INT9397

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Context Info
Confidence 0.60
First Reported 1982
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 8.36
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
plasma 1
CAR 1
neurons 1
pituitary 1
epithelial cells 1
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 281 100.00 Very High Very High Very High
Opioid 93 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
opiate 7 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
Paracetamol 3 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
Lasting pain 29 99.56 Very High Very High Very High
dexamethasone 3 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 309 100.00 Very High Very High Very High
Cancer 263 99.96 Very High Very High Very High
Disease 19 99.84 Very High Very High Very High
Infection 60 98.70 Very High Very High Very High
Fever 4 98.56 Very High Very High Very High
Syndrome 72 98.32 Very High Very High Very High
Paraganglioma 8 97.84 Very High Very High Very High
Stress 7 97.20 Very High Very High Very High
Peripheral Arterial Disease 22 96.88 Very High Very High Very High
Renal Cancer 138 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Met-enk and SP levels in GPL were unchanged in PD.
Neg (unchanged) Regulation (unchanged) of Met in GPL associated with disease and substance p
1) Confidence 0.60 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 7504224 Disease Relevance 0.42 Pain Relevance 0.66
On the other hand, the serum levels of Met-enk, epinephrin, CRF, cortisol and CD57 were not significantly different between the two groups.
Neg (not) Regulation (different) of Met
2) Confidence 0.44 Published 2000 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11072598 Disease Relevance 0.06 Pain Relevance 0
The aim of the study was to evaluate the effect of the guanyl derivative of the opioid analogue D-ala2,MePhe4-Met-enkephalin-(o)-ol (G-DAMME) on pituitary secretion in healthy elderly men.
Regulation (effect) of Met in pituitary associated with enkephalin and opioid
3) Confidence 0.44 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1414144 Disease Relevance 0 Pain Relevance 0.27
[Sensitivity of hypothalamic neurons to beta-endomorphin, met-enkephalin, and thyroliberin].
Regulation ([Sensitivity) of met in neurons associated with enkephalin
4) Confidence 0.44 Published 1982 Journal Biull Eksp Biol Med Section Title Doc Link 6279210 Disease Relevance 0 Pain Relevance 0.77
In the present study we have examined the response of endogenous opiates (beta-EP and Met-enk) and ACTH to a particular type of thermal stimulus such as sauna in 8 young healthy subjects.
Spec (examined) Regulation (response) of Met associated with opiate
5) Confidence 0.44 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 2155166 Disease Relevance 0.31 Pain Relevance 0.17
This means that the COMTval158met polymorphism could affect the response to opioid drugs which was previously observed in a clinical setting including a group of cancer patients [10]–[13].
Regulation (affect) of COMTval158met associated with cancer and opioid
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695541 Disease Relevance 0.76 Pain Relevance 1.36
The different responses of ACTH, beta-EP and Met-enk to heat exposure indicate that hyperthermia represents a form of stress, which can trigger off a well-defined neuroendocrine reaction.
Regulation (responses) of Met associated with stress and fever
7) Confidence 0.26 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 2155166 Disease Relevance 0.37 Pain Relevance 0.16
Our conclusion from the statistical analysis is that the influence of COMTval158met on pain sensitivity is not affected by sex.
Neg (not) Regulation (affected) of COMTval158met associated with pain
8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695541 Disease Relevance 0.82 Pain Relevance 1.25
The effects of a potent opioid peptide agonist [D-ala2-Phe4, Met(0)ol5-enkephalin (FK 33-824) on the magnitude of the oestradiol-induced LH surge and on basal plasma LH concentrations were examined in intact and chronically-ovariectomized ewes during the late-anoestrous period.
Spec (examined) Regulation (effects) of Met in plasma associated with agonist, enkephalin and opioid
9) Confidence 0.19 Published 1990 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 2369818 Disease Relevance 0 Pain Relevance 0.36
The effects of Met-enkephalin (Met-Enk), a delta receptor binding opioid peptide, and its more stable synthetic analogs, Tyr-D-Ala-Gly-MePhe-Met-NHC3H7-iso (1), Tyr-D-Ala-Gly-MePhe-Gly-NHC3H7-iso (2) and Tyr-D-Ala-Gly-MePhe-Gly-NHCH2C6H5 (3), on human T-cell transformation and natural killer (NK) cell cytotoxicity have been evaluated.
Regulation (effects) of Met-Enk in T-cell associated with enkephalin and opioid
10) Confidence 0.14 Published 1995 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7558515 Disease Relevance 0 Pain Relevance 0.27
The low values of limits of detection (LOD) for PAR, SOT, MTZ, MET, SAL, PRO, PRE, CAR, DEX and KET were achieved: 106 ng L(-1), 1,048 ng L(-1), 2.48 ng L(-1), 2.17 ng L(-1), 16.5 ng L(-1), 1.10 ng L(-1), 160 ng L(-1), 6.62 ng L(-1), 76.5 ng L(-1) and 45.2 ng L(-1), respectively.
Regulation (values) of MET in CAR associated with paracetamol and dexamethasone
11) Confidence 0.12 Published 2009 Journal Water Sci. Technol. Section Abstract Doc Link 19633387 Disease Relevance 0.08 Pain Relevance 0.69
The second hypothesis concerned a moderation of the effect of the Met allele by chronic pain complaints (pain status).
Regulation (effect) of Met associated with pain and lasting pain
12) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.92 Pain Relevance 0.92
Thus, it is probable that in our sample, of which approximately half were methamphetamine dependent, the putative protective effect of the Met/Met genotype is diminished and propensity to sexual risk behavior enhanced.
Regulation (effect) of Met
13) Confidence 0.07 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.08 Pain Relevance 0.07
Thus, it is probable that in our sample, of which approximately half were methamphetamine dependent, the putative protective effect of the Met/Met genotype is diminished and propensity to sexual risk behavior enhanced.
Regulation (effect) of Met
14) Confidence 0.07 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.08 Pain Relevance 0.07
these disorders have been identified by positional cloning including the VHL gene, the MET
Regulation (identified) of MET
15) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 2.77 Pain Relevance 0
With respect to OPN expression, transcript levels were fourfold higher in the Met tumor versus the Db tumor.
Regulation (higher) of Met associated with cancer
16) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.01 Pain Relevance 0
This decrease in OPN protein expression was associated with a threefold decrease in the number of cells that migrated, as compared with the vector-transfected Met control.
Regulation (control) of Met
17) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.51 Pain Relevance 0
Recent studies have shown that infection of gastric epithelial cells by the bacterial pathogen H. pylori targets the c-Met receptor and provokes some c-Met-related cellular responses [6].
Regulation (targets) of c-Met in epithelial cells associated with infection
18) Confidence 0.01 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.18 Pain Relevance 0
We restricted our network model explicitly to the signal transduction events that arise from stimulation or modulation of the c-Met receptor.
Regulation (modulation) of c-Met
19) Confidence 0.01 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0 Pain Relevance 0

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