INT9398

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 2.34
Pain Relevance 7.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
vesicles 2
Hepatocyte 1
adrenal medulla 1
pituitary 1
heart 1
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 43 100.00 Very High Very High Very High
Catecholamine 32 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
ischemia 7 99.84 Very High Very High Very High
Nicotine 17 99.82 Very High Very High Very High
Opioid 13 99.52 Very High Very High Very High
Somatostatin 8 99.04 Very High Very High Very High
Neuropeptide 8 98.88 Very High Very High Very High
medulla 5 96.92 Very High Very High Very High
narcan 21 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Coronary Artery Disease 2 99.84 Very High Very High Very High
Hypertension 8 97.68 Very High Very High Very High
Pheochromocytoma 4 96.44 Very High Very High Very High
Cv Unclassified Under Development 5 91.52 High High
Alzheimer's Dementia 4 75.00 Quite High
Disease 3 73.52 Quite High
Cancer 2 66.84 Quite High
Peripheral Arterial Disease 1 59.28 Quite High
Pain 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nicotine (10(-7) M to 10(-4) M) stimulated simultaneous secretion of CAs and Met-enk from the cultured human Ph cells.
Localization (secretion) of Met associated with catecholamine and nicotine
1) Confidence 0.78 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 3788413 Disease Relevance 0.19 Pain Relevance 0.71
Met-enk, however, was not secreted in proportion to either epinephrine (E), norepinephrine (NE) or total CAs (E + NE).
Neg (not) Localization (secreted) of Met associated with catecholamine
2) Confidence 0.78 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 3788413 Disease Relevance 0.19 Pain Relevance 0.72
In 6, Ph cells were cultured, and the modes of secretion of CAs and Met-enk were examined.
Localization (secretion) of Met associated with catecholamine
3) Confidence 0.78 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 3788413 Disease Relevance 0.15 Pain Relevance 0.49
In chromaffin cells, calcium-dependent secretion of KPI/APP with PTP and (Met)enkephalin demonstrated the colocalization of these components in functional secretory vesicles.
Localization (secretion) of Met in vesicles associated with enkephalin
4) Confidence 0.78 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 9915856 Disease Relevance 0.15 Pain Relevance 0.27
Thus, it appears that there is no Met-enk extraction from the coronary circulation during provoked myocardial ischemia and no Met-enk release from the ischemic heart.
Localization (release) of Met in heart associated with coronary artery disease and ischemia
5) Confidence 0.78 Published 2001 Journal Peptides Section Abstract Doc Link 11445249 Disease Relevance 0.35 Pain Relevance 0.37
The ultrastructural localization of substance P (SP), met-enkephalin (MENK), and somatostatin (SS) in the lamina X area surrounding the central canal of the macaque monkey was examined by the indirect peroxidase-antiperoxidase method.
Spec (examined) Localization (localization) of met in central canal associated with somatostatin, enkephalin and substance p
6) Confidence 0.78 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1711056 Disease Relevance 0 Pain Relevance 0.59
These findings go against a direct action of beta h-End, Met-Enk and DALA on TSH secretion.
Localization (secretion) of Met
7) Confidence 0.73 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2412379 Disease Relevance 0 Pain Relevance 0.62
Tissue contents of CAs and Met-enk varied from patient to patient, but larger amounts of Met-enk were found in medullary Phs than extramedullary ones, regardless of the secreting CA type.
Localization (secreting) of Met associated with catecholamine
8) Confidence 0.73 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 3788413 Disease Relevance 0.18 Pain Relevance 0.62
Among the various biologically active peptides tested, the purified enzyme releases efficiently the N-terminal dipeptide moiety from enkephalins, Trp-Met-Asp-Phe-NH2 (CCK4), and Gly-Trp-Met-Asp-Phe-NH2 (CCK5).
Localization (releases) of Met associated with enkephalin
9) Confidence 0.68 Published 1986 Journal Biochemistry Section Abstract Doc Link 3814577 Disease Relevance 0 Pain Relevance 0.37
In chromaffin cells, calcium-dependent secretion of KPI/APP with PTP and (Met)enkephalin demonstrated the colocalization of these components in functional secretory vesicles.
Localization (colocalization) of Met in vesicles associated with enkephalin
10) Confidence 0.68 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 9915856 Disease Relevance 0.15 Pain Relevance 0.27
The aim of the study was to evaluate the effect of the guanyl derivative of the opioid analogue D-ala2,MePhe4-Met-enkephalin-(o)-ol (G-DAMME) on pituitary secretion in healthy elderly men.
Localization (secretion) of Met in pituitary associated with enkephalin and opioid
11) Confidence 0.68 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1414144 Disease Relevance 0 Pain Relevance 0.27
These findings are consistent with the hypothesis that Met-Enk may be a noncholinergic, excitatory transmitter released by field stimulation of nerves or intra-arterial motilin in the canine intestine.
Localization (released) of Met in intestine
12) Confidence 0.68 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3618779 Disease Relevance 0 Pain Relevance 0.39
Immunohistochemical studies for multiple peptide-immunoreactivities and co-localization of Met-enkephalin-Arg6-Gly7-Leu8, neuropeptide Y and somatostatin in human adrenal medulla and pheochromocytomas.
Localization (co-localization) of Met in adrenal medulla associated with medulla, somatostatin, neuropeptide, enkephalin and pheochromocytoma
13) Confidence 0.68 Published 1987 Journal Peptides Section Title Doc Link 2883635 Disease Relevance 0.42 Pain Relevance 0.48
In addition, these compounds inhibited the f-Met-Leu-Phe (FMLP)-induced MPO release from PMN.
Localization (release) of Met in PMN associated with urological neuroanatomy
14) Confidence 0.68 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.44 Pain Relevance 0.49
Furthermore, expression of cathepsin L with PE resulted in increased amounts of nicotine-induced secretion of (Met)enkephalin.
Localization (secretion) of Met associated with nicotine and enkephalin
15) Confidence 0.68 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 1.02
Hepatocyte growth factor is secreted by vascular endothelial cells and smooth muscle cells, and the hepatocyte growth factor receptor, c-met, was also observed in these vascular cells.
Localization (secreted) of c-met in Hepatocyte
16) Confidence 0.04 Published 2005 Journal Expert Rev Cardiovasc Ther Section Abstract Doc Link 15889978 Disease Relevance 0.13 Pain Relevance 0

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