INT94

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Context Info
Confidence 0.46
First Reported 1976
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.97
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
hypothalamus 2
blood 2
sympathetic 2
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 9 100.00 Very High Very High Very High
Hippocampus 6 100.00 Very High Very High Very High
MU agonist 2 99.22 Very High Very High Very High
ischemia 1 99.00 Very High Very High Very High
Serotonin 1 90.84 High High
noradrenaline 4 88.72 High High
anesthesia 7 87.28 High High
halothane 2 86.28 High High
opioid receptor 9 85.48 High High
agonist 1 82.84 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 1 99.00 Very High Very High Very High
Pressure Volume 2 Under Development 3 97.70 Very High Very High Very High
Injury 1 97.56 Very High Very High Very High
Myocardial Infarction 2 92.40 High High
Bordatella Infection 1 90.76 High High
Hypoxia 1 87.52 High High
Glioma 2 75.00 Quite High
Hypertension 2 55.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present paper we show that cell exposure to opioid agonists during DMI treatment counteracted DMI-induced beta-receptor loss.
Positive_regulation (induced) of Negative_regulation (loss) of beta-receptor associated with mu agonist
1) Confidence 0.46 Published 1987 Journal Brain Res. Section Abstract Doc Link 2823987 Disease Relevance 0.15 Pain Relevance 0.59
The hemodynamic responses to blood loss amounting to 25 per cent of estimated blood volume, and its subsequent replacement, were studied before and after induction of beta-receptor blockade.
Positive_regulation (induction) of Negative_regulation (blockade) of beta-receptor in blood associated with pressure volume 2 under development
2) Confidence 0.39 Published 1976 Journal Anesthesiology Section Abstract Doc Link 9020 Disease Relevance 0.34 Pain Relevance 0.37
In myocardial ischemia, when the sympathetic activity is increased, the inhibition of beta-AR stimulation by kappa-opioid stimulation is also enhanced, thus reducing the workload, oxygen consumption and cardiac injury.
Positive_regulation (enhanced) of Negative_regulation (inhibition) of beta-AR in sympathetic associated with coronary artery disease, ischemia, injury and opioid
3) Confidence 0.35 Published 2001 Journal J. Biomed. Sci. Section Abstract Doc Link 11455191 Disease Relevance 0.48 Pain Relevance 0.64
Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4.
Positive_regulation (increased) of Negative_regulation (numbers) of Beta adrenoceptor in hypothalamus associated with hippocampus
4) Confidence 0.23 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 7505893 Disease Relevance 0 Pain Relevance 0.55

General Comments

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