INT940

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 219
Total Number 222
Disease Relevance 104.34
Pain Relevance 95.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
brain 4
platelet 3
skin 3
colon 3
macrophage 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 935 100.00 Very High Very High Very High
COX2 75 100.00 Very High Very High Very High
cOX1 59 100.00 Very High Very High Very High
cINOD 1002 99.98 Very High Very High Very High
Paracetamol 244 99.92 Very High Very High Very High
agonist 220 99.92 Very High Very High Very High
cytokine 148 99.92 Very High Very High Very High
Potency 46 99.92 Very High Very High Very High
acular 44 99.92 Very High Very High Very High
dexamethasone 15 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1276 100.00 Very High Very High Very High
Pressure And Volume Under Development 190 99.92 Very High Very High Very High
Fever 23 99.92 Very High Very High Very High
Toxicity 94 99.84 Very High Very High Very High
Pain 224 99.72 Very High Very High Very High
Targeted Disruption 154 99.70 Very High Very High Very High
Disease 694 99.60 Very High Very High Very High
Cancer 750 99.58 Very High Very High Very High
Inflammatory Pain 10 99.34 Very High Very High Very High
Colon Cancer 86 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the present study was to develop a biochemical marker of inhibition of cyclooxygenase in the central nervous system following oral administration of cyclooxygenase inhibitors.
Negative_regulation (inhibition) of cyclooxygenase in central nervous system associated with central nervous system
1) Confidence 0.59 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2142085 Disease Relevance 0 Pain Relevance 0.24
Thus while cyclooxygenase inhibitors did not reduce normal prostaglandin E2 levels in brain, they did attenuate post-mortem increases in prostaglandin E2.
Negative_regulation (inhibitors) of cyclooxygenase in brain
2) Confidence 0.59 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2142085 Disease Relevance 0 Pain Relevance 0.30
METHODS: Non selective cyclooxygenase enzyme inhibitors (100 mg/kg acetylsalicylic acid, 10 mg/kg inhibitors (100 mg/kg acetylsalicylic acid, 10 mg/kg indomethacin, and 10 mg/kg diclofenac), a selective cyclooxygnase-1 inhibitor (10 mg/kg acetylsalicylic acid), and a selective cyclooxygnase-2 inhibitor (10 mg/kg celecoxib) of non steroidal anti-inflammatory drugs were individually pretreated to 15 and 24 groups of Albino mice for dose and time dependent models (n = 8, each treatment) before sleeping induced by diazepam (20 mg/kg, intraperitoneally).
Negative_regulation (inhibitors) of cyclooxygenase
3) Confidence 0.59 Published 2010 Journal Neurosciences (Riyadh) Section Body Doc Link 20672494 Disease Relevance 0.10 Pain Relevance 0
The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents.
Negative_regulation (inhibition) of cyclooxygenase associated with inflammation, cinod and antinociceptive
4) Confidence 0.59 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12564643 Disease Relevance 0.17 Pain Relevance 0.65
The results obtained in this study confirm that NSAIDs possess different abilities to induce inhibition of cyclooxygenase, and they can be indirectly assessed by their different antinociceptive activities, depending on the algesiometric assays that are used.
Negative_regulation (inhibition) of cyclooxygenase associated with cinod and antinociceptive
5) Confidence 0.58 Published 2001 Journal Pain Res Manag Section Abstract Doc Link 11854764 Disease Relevance 0.29 Pain Relevance 1.46
This effect seems to be related to cyclooxygenase inhibition.
Negative_regulation (inhibition) of cyclooxygenase
6) Confidence 0.58 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10678502 Disease Relevance 0.63 Pain Relevance 0.58
The original premise in these studies was that nonsteroidal anti-inflammatory drugs, through inhibition of cyclooxygenase activity, would suppress the attending generation of superoxide anions and reduce a synergism with oxygen radicals produced by redox cycling of doxorubicin.
Negative_regulation (inhibition) of cyclooxygenase associated with inflammation and cinod
7) Confidence 0.58 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2139234 Disease Relevance 0.52 Pain Relevance 0.51
Diclofenac has an antinociceptive activity that, in addition to cyclooxygenase inhibition, can be modulated by additive and supraadditive interactions with adrenergic drugs.
Negative_regulation (inhibition) of cyclooxygenase associated with antinociceptive and diclofenac
8) Confidence 0.58 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11473875 Disease Relevance 0.08 Pain Relevance 1.44
Inhibition of cyclooxygenase and its metabolites may have been involved in the mechanism of action of this plant, considering previous studies reporting the anti-inflammatory and analgesic activity for the identified lignans, as well as anti-inflammatory activity for lupeol.
Negative_regulation (Inhibition) of cyclooxygenase associated with inflammation and analgesic
9) Confidence 0.58 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17725859 Disease Relevance 0.62 Pain Relevance 0.62
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Negative_regulation (inhibition) of cyclooxygenase associated with aspirin, inflammation and cinod
10) Confidence 0.58 Published 1993 Journal J. Biol. Chem. Section Title Doc Link 8454631 Disease Relevance 0.19 Pain Relevance 0.64
ID50 values were determined for a panel of common NSAIDs by measuring instantaneous inhibition of cyclooxygenase activity using an oxygen electrode.
Negative_regulation (inhibition) of cyclooxygenase associated with cinod
11) Confidence 0.58 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8454631 Disease Relevance 0.16 Pain Relevance 0.60
Among common NSAIDs tested, indomethacin, sulindac sulfide, and piroxicam preferentially inhibited PGH synthase-1; ibuprofen, flurbiprofen, and meclofenamate inhibited both enzymes with comparable potencies; and 6-methoxy-2-naphthylacetic acid preferentially inhibited PGH synthase-2.
Negative_regulation (inhibited) of PGH synthase-1 associated with cinod
12) Confidence 0.58 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8454631 Disease Relevance 0.16 Pain Relevance 0.59
A correlation between the activity in the three tests has been found for most NSAID studied, and the results point to inhibition of cyclooxygenase as a common mechanism of action.
Negative_regulation (inhibition) of cyclooxygenase associated with cinod
13) Confidence 0.58 Published 1979 Journal Agents Actions Suppl. Section Abstract Doc Link 115259 Disease Relevance 0.36 Pain Relevance 0.38
The antinociceptive activity of nonsteroidal anti-inflammatory drugs (NSAIDs) has been explained mainly on the basis of their inhibition of the enzyme cyclooxygenase (COX); however, this inhibition is not enough to completely explain the analgesic efficacy of these drugs.
Negative_regulation (inhibition) of enzyme cyclooxygenase associated with inflammation, analgesic, cinod and antinociceptive
14) Confidence 0.58 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12909285 Disease Relevance 0.17 Pain Relevance 0.95
Conversely, inhibition of PGHS-1 is believed to cause the toxic effects of NSAIDs, such as gastric and renal damage.
Negative_regulation (inhibition) of PGHS-1 associated with cinod
15) Confidence 0.58 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023270 Disease Relevance 0.17 Pain Relevance 0.49
When calcium ionophore A23187 was used to mobilize endogenous AA, acetylsalicylic acid and indomethacin equipotently inhibited both PGHS-1 and PGHS-2 isozymes.
Negative_regulation (inhibited) of PGHS-1 associated with aspirin
16) Confidence 0.58 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023270 Disease Relevance 0.31 Pain Relevance 0.70
NS-398 remained highly selective for PGHS-2 in 10T1/2 and AS52 cells but also effectively (100%) inhibited PGHS-1 in AS52 cells.
Negative_regulation (inhibited) of PGHS-1 in AS52
17) Confidence 0.58 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023270 Disease Relevance 0.32 Pain Relevance 0.71
When exogenous AA was used, acetylsalicylic acid was a 5- to 10-fold more potent inhibitor of PGHS-1, whereas indomethacin was a 4- to 5-fold more potent inhibitor of PGHS-2.
Negative_regulation (inhibitor) of PGHS-1 associated with aspirin
18) Confidence 0.58 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023270 Disease Relevance 0.22 Pain Relevance 0.57
Accordingly, it may be considered that the actions of mofezolac are due to the inhibition of cyclooxygenase.
Negative_regulation (inhibition) of cyclooxygenase
19) Confidence 0.58 Published 1990 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 2109726 Disease Relevance 0.24 Pain Relevance 0.35
Using this model of nociception, it is possible to identify the site of action of analgesic drugs which reduce prostaglandin release in central tissues through inhibition of cyclooxygenase.
Negative_regulation (inhibition) of cyclooxygenase associated with nociception and analgesic
20) Confidence 0.57 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20645177 Disease Relevance 0.70 Pain Relevance 0.49

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