INT94002

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 8.41
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lox) oxidoreductase activity (Lox) extracellular region (Lox)
proteinaceous extracellular matrix (Lox) nucleus (Lox)
Anatomy Link Frequency
blood 1
plasma 1
colon 1
neurons 1
Lox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 195 99.88 Very High Very High Very High
cINOD 5 97.76 Very High Very High Very High
qutenza 19 96.24 Very High Very High Very High
chemokine 3 95.44 Very High Very High Very High
Inflammatory response 10 92.16 High High
fibrosis 14 91.56 High High
addiction 2 84.56 Quite High
antagonist 4 83.88 Quite High
tetrodotoxin 2 67.28 Quite High
Spinal cord 12 60.72 Quite High
Disease Link Frequency Relevance Heat
Stress 28 99.90 Very High Very High Very High
INFLAMMATION 216 99.88 Very High Very High Very High
Infection 57 99.64 Very High Very High Very High
Cancer 236 99.40 Very High Very High Very High
Hypotension 2 98.52 Very High Very High Very High
Disease 35 98.12 Very High Very High Very High
Fibrosis 16 96.52 Very High Very High Very High
Bacterial Infection 6 96.48 Very High Very High Very High
Apoptosis 23 92.68 High High
Hypertension 28 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From the IPA analysis, we found a much higher up-regulation of lysyl oxidase than that reported in our previous study [10].
Regulation (regulation) of lysyl oxidase
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 1.38 Pain Relevance 0.31
Analysis of focus genes in networks, functional analysis, and canonical pathway analysis reinforced our previous findings related to the presence of up-regulated genes involved in tissue remodeling, such as lysyl oxidase, tropoelastin, TGF-?
Regulation (regulated) of lysyl oxidase
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688838 Disease Relevance 0.93 Pain Relevance 0.21
A number of studies have been conducted that support curcumin-mediated regulation of COX and LOX pathways, which is an important mechanism by which curcumin prevents a number of disease processes, including the cancer.
Regulation (regulation) of LOX associated with cancer and disease
3) Confidence 0.30 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17569213 Disease Relevance 0.72 Pain Relevance 0.22
In this review, we discuss evidence that supports the regulation of COX and LOX enzymes by curcumin as the key mechanism for its beneficial effects in preventing various inflammatory diseases.
Regulation (regulation) of LOX associated with inflammation and disease
4) Confidence 0.30 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17569213 Disease Relevance 0.61 Pain Relevance 0.23
The specific regulation of 5-LOX and COX-2 by curcumin is not fully established; however, existing evidence indicates that curcumin regulates LOX and COX-2 predominately at the transcriptional level and, to a certain extent, the posttranslational level.
Regulation (regulation) of LOX
5) Confidence 0.19 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17569213 Disease Relevance 0.70 Pain Relevance 0.22
Regulation of COX and LOX by curcumin.
Regulation (Regulation) of LOX
6) Confidence 0.11 Published 2007 Journal Adv. Exp. Med. Biol. Section Title Doc Link 17569213 Disease Relevance 0.62 Pain Relevance 0.16
Thus, the mitochondrial subunits may play a more important role in regulating cytochrome c oxidase protein amount and activity in neurons.
Regulation (regulating) of oxidase protein in neurons
7) Confidence 0.11 Published 2006 Journal Neuroscience Section Abstract Doc Link 16542778 Disease Relevance 0 Pain Relevance 0.12
Metabolic inhibitors had little effect on surface NAD(P)H-oxidase activity but inhibited trans-plasma membrane activity.
Neg (little) Regulation (effect) of H-oxidase in plasma
8) Confidence 0.04 Published 2000 Journal Antioxid. Redox Signal. Section Abstract Doc Link 11229532 Disease Relevance 0 Pain Relevance 0.13
Comparison of NAD(P)H-oxidase on the surface of viable cells with trans-membrane NADH-oxidoreductase, measured with WST-1 in the presence of 1-methoxy PMS, showed that cell-surface NAD(P)H-oxidase was differentially inhibited by the cell-impermeable thiol-blocking agent pCMBS, but was unaffected or stimulated by other thiol blocking agents.
Neg (unaffected) Regulation (unaffected) of H-oxidase
9) Confidence 0.03 Published 2000 Journal Antioxid. Redox Signal. Section Abstract Doc Link 11229532 Disease Relevance 0 Pain Relevance 0.14
Several studies showed NSAID played significant chemopreventive effects against H. pylori-induced gastric carcinogenesis through attenuating COX activities, but our study opens the possibility that LOX activity as much as COX activity might influence the inflammatory or carcinogenic activities related to its disasters associated with H. pylori infection, suggesting that modulation of activities of both COX and LOX will be quite beneficial in avoiding the deleterious outcomes of chronic H. pylori infection.


Regulation (modulation) of LOX associated with inflammation, cinod and infection
10) Confidence 0.02 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872224 Disease Relevance 0.66 Pain Relevance 0.18
Diosgenin also inhibits azoxymethane-induced aberrant colon crypt foci, has been shown to inhibit intestinal inflammation, and modulates the activity of LOX and COX-2.
Regulation (modulates) of LOX in colon associated with inflammation
11) Confidence 0.02 Published 2008 Journal Pharm Res Section Body Doc Link PMC2515569 Disease Relevance 1.13 Pain Relevance 0.18
The underlying mechanism of anti-oxidative blood pressure lowering effects of spironolactone can be explained through its potent inhibitory effects on NAD(P)H oxidase activity.
Regulation (effects) of H oxidase in blood associated with hypotension
12) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.75 Pain Relevance 0.10
The pro-inflammatory and pro-fibrotic effect of aldosterone induces target cell and organ to be damaged structurally, functionally and mechanically, in particular due to aldosterone induced oxidative stress via modulation of NAD(P)H oxidase (6).
Regulation (modulation) of H oxidase associated with stress, fibrosis and inflammation
13) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.92 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox