INT9401

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 110
Total Number 113
Disease Relevance 72.76
Pain Relevance 41.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 8
macrophages 4
blood 3
T cells 3
monocytes 2
tnf-alpha (Salmo salar)
Pain Term Frequency Confidence Heat
antagonist 25 100.00 Very High Very High Very High
Inflammation 176 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
tricyclic antidepressant 1 100.00 Very High Very High Very High
cytokine 296 100.00 Very High Very High Very High
cINOD 25 100.00 Very High Very High Very High
Inflammatory marker 6 100.00 Very High Very High Very High
beta blocker 1 100.00 Very High Very High Very High
Pain 52 100.00 Very High Very High Very High
agonist 21 100.00 Very High Very High Very High
Disease Term Frequency Confidence Heat
Acromegaly 2 100.00 Very High Very High Very High
INFLAMMATION 221 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Insulin Resistance 2 100.00 Very High Very High Very High
Spinal Cord Diseases 1 100.00 Very High Very High Very High
Obesity 4 100.00 Very High Very High Very High
Cancer 14 100.00 Very High Very High Very High
Syndrome 8 99.96 Very High Very High Very High
Apoptosis 37 99.96 Very High Very High Very High
Pressure And Volume Under Development 80 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H. pylori lipopolysaccharide elicited within 2 days a pattern of acute mucosal inflammatory responses accompanied by a massive epithelial cell apoptosis, and a marked increase in the expression of membrane-bound and soluble forms of TNF-alpha.
Gene_expression (expression) of TNF-alpha in epithelial cell associated with inflammatory response and apoptosis
1) Confidence 0.75 Published 2001 Journal J. Endotoxin Res. Section Abstract Doc Link 11581571 Disease Relevance 1.16 Pain Relevance 0.62
This detrimental influence of aspirin appears to result from up-regulation in the mucosal expression of soluble form of TNF-alpha, which leads to the amplification of apoptotic events that potentiate gastric mucosal inflammatory reaction to H. pylori.
Gene_expression (expression) of TNF-alpha associated with aspirin, inflammation and apoptosis
2) Confidence 0.75 Published 2001 Journal J. Endotoxin Res. Section Abstract Doc Link 11581571 Disease Relevance 0.91 Pain Relevance 0.43
In contrast, administration of indomethacin evoked only a marginal increase (5-7%) in apoptosis, and caused no discernible changes in the severity of gastric mucosal involvement and the expression of TNF-alpha forms elicited by H. pylori lipopolysaccharide.
Gene_expression (expression) of TNF-alpha associated with apoptosis
3) Confidence 0.75 Published 2001 Journal J. Endotoxin Res. Section Abstract Doc Link 11581571 Disease Relevance 0.85 Pain Relevance 0.50
Alternatively TNF alpha production may represent the result of the neuroendocrine response such as cortisol and norepinephrine, to the surgical/anaesthetic trauma which could be blocked by subarachnoid anaesthesia.
Gene_expression (production) of TNF alpha associated with injury
4) Confidence 0.74 Published 1998 Journal Ann Ital Chir Section Abstract Doc Link 11995034 Disease Relevance 0.10 Pain Relevance 0.14
Anti-TNF-alpha treatment: a possible promoter in endogenous uveitis?
Gene_expression (treatment) of TNF-alpha associated with uveitis
5) Confidence 0.65 Published 2010 Journal Curr. Eye Res. Section Title Doc Link 20673052 Disease Relevance 0.55 Pain Relevance 0.34
[Therapeutic use of anti-TNF-alpha agents in spondyloarthropathies].
Gene_expression (agents) of TNF-alpha
6) Confidence 0.56 Published 2003 Journal Presse Med Section Title Doc Link 14534471 Disease Relevance 0.69 Pain Relevance 0.50
Predisposition of infliximab-treated individuals, as occurs with other anti-TNF-alpha agents, to cause an increase of conventional pyogenic infections (of the skin and soft tissues, respiratory tract, genitourinary tracts and bacteriemias) and an increase in granulomatous and opportunistic infections due to invasive or intracellular pathogens (such as Mycobacterium tuberculosis), has been well established and quantified in the last five years.
Gene_expression (agents) of anti-TNF-alpha in skin associated with mycobacterial infection, opportunistic infections, infliximab and infection
7) Confidence 0.50 Published 2008 Journal Actas Dermosifiliogr Section Abstract Doc Link 19080987 Disease Relevance 2.22 Pain Relevance 0.41
We presently know that the initiation of screening strategies of latent infections (especially tuberculosis) in the host candidate to receive anti-TNF-alpha drugs, with their corresponding early treatment to avoid reactivations, and other prophylaxis, hygiene and vaccination measures have not only minimized these risks of suffering infections but also have practically reduced and equalized the different capacity to trigger infections belonging to each one of the biological agents individually.
Gene_expression (drugs) of anti-TNF-alpha associated with mycobacterial infection and infection
8) Confidence 0.50 Published 2008 Journal Actas Dermosifiliogr Section Abstract Doc Link 19080987 Disease Relevance 1.78 Pain Relevance 0.28
[Does TNF-alpha contribute to liver disease physiopathology?].
Gene_expression (contribute) of TNF-alpha in liver associated with liver disease
9) Confidence 0.46 Published 2000 Journal Acta Gastroenterol. Latinoam. Section Title Doc Link 10975018 Disease Relevance 0.56 Pain Relevance 0.23
Levels of IL-6 and TNF-alpha in pericardial effusion were extremely higher than those in serum.
Gene_expression (Levels) of TNF-alpha associated with pressure and volume under development
10) Confidence 0.29 Published 2008 Journal Lupus Section Abstract Doc Link 18852229 Disease Relevance 0.93 Pain Relevance 0.11
In each patients serum levels of TNF alpha and IL-10 were measured according to the special protocol by ELISA.
Gene_expression (levels) of TNF alpha
11) Confidence 0.28 Published 1999 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 10948700 Disease Relevance 1.20 Pain Relevance 0.39
[Proposal of Croatian Society for Rheumatology for anti-TNF-alpha therapy in adult patients with spondyloarthritides].
Gene_expression (therapy) of TNF-alpha
12) Confidence 0.26 Published 2007 Journal Reumatizam Section Title Doc Link 18450273 Disease Relevance 0.43 Pain Relevance 0.18
[A case of meningeal carcinomatosis showing myelopathy--detection of TNF-alpha in infiltrating CSF cells and brain tissue sections of cerebellum].
Gene_expression (myelopathy--detection) of TNF-alpha in brain associated with spinal cord diseases and meningeal carcinomatosis
13) Confidence 0.26 Published 1993 Journal Rinsho Shinkeigaku Section Title Doc Link 8319390 Disease Relevance 1.09 Pain Relevance 0.22
This paper reviews data supporting the treatment of sleep apnoea with various pharmacological agents, including intranasal corticosteroids, decongestant sprays, nicotine therapy, opiate antagonists, methylxanthine derivatives, oestrogen and progesterone, testosterone, thyroid hormone, growth hormone therapy for acromegaly, beta-blockers, alpha-adrenergic agonists, angiotensin-converting enzyme inhibitors, glutamate antagonists, acetazolamide, selective serotonin re-uptake inhibitors, tricyclic antidepressants, physostigmine, modafinil and TNF-alpha antagonists, in addition to supplemental oxygen, and carbon dioxide inhalation.
Gene_expression (therapy) of TNF-alpha in thyroid associated with acromegaly, apnoea, corticosteroid, nicotine, tricyclic antidepressant, glutamate, beta blocker, antagonist, agonist, opiate and serotonin
14) Confidence 0.26 Published 2006 Journal Expert Opin Pharmacother Section Abstract Doc Link 16370918 Disease Relevance 0.82 Pain Relevance 0.59
This prompted further exploration into other signalling mechanisms possibly involved in TNF-alpha action and production, notably the p38 MAPK and the PI3K pathway.
Gene_expression (production) of TNF-alpha
15) Confidence 0.22 Published 2006 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17026837 Disease Relevance 0.28 Pain Relevance 0.16
Therefore, by counteracting the properties of TNF-alpha and/or its production, the imidazo[1,2-alpha]quinoxalines could be considered as potential anti-inflammatory drugs.
Gene_expression (production) of TNF-alpha associated with inflammation and cinod
16) Confidence 0.22 Published 2006 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17026837 Disease Relevance 0.33 Pain Relevance 0.18
Impairment of TNF-alpha production and action by imidazo[1,2- alpha] quinoxalines, a derivative family which displays potential anti-inflammatory properties.
Gene_expression (production) of TNF-alpha associated with inflammation
17) Confidence 0.22 Published 2006 Journal Int J Immunopathol Pharmacol Section Title Doc Link 17026837 Disease Relevance 0.23 Pain Relevance 0.15
Moreover, when the effect of the 8-series on TNF-alpha production was investigated using gamma9delta2 T cells, it was observed that these compounds impaired the TCR:CD3-triggered TNF-alpha production.
Gene_expression (production) of TNF-alpha in T cells
18) Confidence 0.22 Published 2006 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17026837 Disease Relevance 0.31 Pain Relevance 0.14
CONCLUSIONS: Under the present study design anesthetic technique did not affect IL-6 or TNF-alpha concentrations in parturients undergoing elective cesarean section.
Gene_expression (concentrations) of TNF-alpha
19) Confidence 0.20 Published 2009 Journal Int J Obstet Anesth Section Body Doc Link 19026531 Disease Relevance 0 Pain Relevance 0
Moreover, when the effect of the 8-series on TNF-alpha production was investigated using gamma9delta2 T cells, it was observed that these compounds impaired the TCR:CD3-triggered TNF-alpha production.
Gene_expression (production) of TNF-alpha in T cells
20) Confidence 0.19 Published 2006 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 17026837 Disease Relevance 0.32 Pain Relevance 0.15

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