INT94010

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 4.23
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
endothelial cells 6
platelet 6
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 14 99.98 Very High Very High Very High
agonist 21 99.84 Very High Very High Very High
antagonist 14 95.20 Very High Very High Very High
Sumatriptan 7 93.60 High High
Inflammation 43 92.52 High High
cytokine 12 91.68 High High
cocaine 2 54.72 Quite High
anakinra 4 51.36 Quite High
headache 11 46.96 Quite Low
Migraine 4 46.40 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 4 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 10 98.40 Very High Very High Very High
Acute Coronary Syndrome 72 98.12 Very High Very High Very High
INFLAMMATION 46 92.52 High High
Nicotine Addiction 9 91.52 High High
Thrombosis 6 89.40 High High
Infection 38 86.88 High High
Coagulation Disorder 4 84.68 Quite High
Malaria 68 75.12 Quite High
Syndrome 5 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin (5-hydroxytryptamine, 5-HT), a local transmitter substance released by activated platelets, has also recently been shown to induce the secretion of vWf.
Positive_regulation (induce) of Localization (secretion) of vWf in platelets associated with serotonin
1) Confidence 0.70 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.28
Together, these results suggest that in HUVEC 5-HT-induced secretion of vWf is mediated by a decrease in cyclic AMP levels and is independent of changes in cytoplasmic calcium levels.
Positive_regulation (mediated) of Localization (secretion) of vWf
2) Confidence 0.70 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.28
Stimulated secretion of vWf from these organelles is thought to be induced by agonists causing a transient increase in cytoplasmic calcium concentrations.
Positive_regulation (Stimulated) of Localization (secretion) of vWf associated with agonist
3) Confidence 0.70 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.22
Together, these results suggest that in HUVEC 5-HT-induced secretion of vWf is mediated by a decrease in cyclic AMP levels and is independent of changes in cytoplasmic calcium levels.
Positive_regulation (induced) of Localization (secretion) of vWf
4) Confidence 0.70 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.28
Serotonin-induced secretion of von Willebrand factor from human umbilical vein endothelial cells via the cyclic AMP-signaling systems independent of increased cytoplasmic calcium concentration.
Positive_regulation (induced) of Localization (secretion) of von Willebrand factor in endothelial cells associated with serotonin
5) Confidence 0.70 Published 1999 Journal Biochem. Pharmacol. Section Title Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.25
Stimulation of endothelial cells with the adenylate cyclase inhibitor, MDL-12 A330, led to the secretion of vWf as well.
Positive_regulation (led) of Localization (secretion) of vWf in endothelial cells
6) Confidence 0.47 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.30
Stimulated secretion of vWf from these organelles is thought to be induced by agonists causing a transient increase in cytoplasmic calcium concentrations.
Positive_regulation (induced) of Localization (secretion) of vWf associated with agonist
7) Confidence 0.47 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.23
Release of von Willebrand factor (vWF) may mediate this platelet adhesion [35].
Spec (may) Positive_regulation (mediate) of Localization (Release) of von Willebrand factor in platelet associated with adhesions
8) Confidence 0.31 Published 2009 Journal Malar J Section Body Doc Link PMC2794284 Disease Relevance 1.94 Pain Relevance 0.15
Release of von Willebrand factor (vWF) may mediate this platelet adhesion [35].
Spec (may) Positive_regulation (mediate) of Localization (Release) of vWF in platelet associated with adhesions
9) Confidence 0.31 Published 2009 Journal Malar J Section Body Doc Link PMC2794284 Disease Relevance 1.94 Pain Relevance 0.15
IL-1 has been shown to augment thrombin-induced release of vWF from human endothelial cells [35].


Positive_regulation (induced) of Localization (release) of vWF in endothelial cells
10) Confidence 0.18 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.36 Pain Relevance 0.34

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