INT94026

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 10.28
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPING1) extracellular region (SERPING1)
SERPING1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 91 97.82 Very High Very High Very High
headache 13 85.12 High High
abdominal pain 21 78.16 Quite High
Onset of action 2 59.32 Quite High
anesthesia 1 9.76 Low Low
b2 receptor 24 5.00 Very Low Very Low Very Low
antagonist 20 5.00 Very Low Very Low Very Low
Pain 19 5.00 Very Low Very Low Very Low
B1 receptor 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Angioedema 639 100.00 Very High Very High Very High
Renal Failure 6 100.00 Very High Very High Very High
Disease 63 99.96 Very High Very High Very High
Laryngeal Edema 57 99.48 Very High Very High Very High
Pressure And Volume Under Development 280 98.36 Very High Very High Very High
Membranous Glomerulonephritis 17 97.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 26 96.08 Very High Very High Very High
Disorder Of Lipid Metabolism 12 95.76 Very High Very High Very High
Hepatitis 45 95.68 Very High Very High Very High
Urticaria 12 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If antibodies are negative, the diagnosis of AAE is assumed when complete screening of C1-INH gene gives no evidence of mutations affecting C1-INH protein.
Regulation (affecting) of C1-INH associated with pressure and volume under development
1) Confidence 0.61 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2925362 Disease Relevance 0.73 Pain Relevance 0
Because the anabolic androgens are more reliably effective for the control of HAE, they were generally used in preference to antifibrinolytics in adult patients with the antifibrinolytic drugs often reserved for patients who didn't tolerate anabolic androgens.
Regulation (control) of HAE associated with hereditary angioedema
2) Confidence 0.52 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.67 Pain Relevance 0
The C1-INH concentrate was effective in all laryngeal edemas.
Regulation (effective) of C1-INH
3) Confidence 0.45 Published 2001 Journal Arch. Intern. Med. Section Body Doc Link 11231704 Disease Relevance 0.06 Pain Relevance 0
This group also examined the safety of C1-INH concentrate in these patients.
Spec (examined) Regulation (safety) of C1-INH
4) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.89 Pain Relevance 0.09
Based on over 20 years of data, including recently completed double-blind, placebo-controlled trials, C1-INH concentrate appears to be very effective in the treatment of acute HAE attacks.
Spec (appears) Regulation (effective) of C1-INH associated with hereditary angioedema
5) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.26 Pain Relevance 0
Also from that publication was a study on acute HAE attacks in which patients were randomly assigned to receive C1-INH concentrate versus placebo for acute treatment.
Regulation (receive) of C1-INH associated with hereditary angioedema
6) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.59 Pain Relevance 0
Bork and Barnstedt (2001) compiled data from HAE patients in Germany who received C1-INH concentrate for laryngeal edema and compared the length of attacks with patients who had laryngeal edema in the past, but did not receive C1-INH concentrate.
Neg (not) Regulation (receive) of C1-INH associated with hereditary angioedema and laryngeal edema
7) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 1.09 Pain Relevance 0.08
This could be anticipated based on the fact that in both forms angioedema is mediated by bradykinin episodically released by inappropriate activation of the contact-kinin system lacking its major physiologic regulator C1-INH [6,7].
Regulation (regulator) of C1-INH associated with pressure and volume under development and bradykinin
8) Confidence 0.39 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2925362 Disease Relevance 1.30 Pain Relevance 0.13
Beginning in the late 1970s, a number of investigators in Europe and the United States began demonstrating that replacement therapy with C1INH concentrates was effective in HAE.
Regulation (effective) of HAE associated with hereditary angioedema
9) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.76 Pain Relevance 0
The first was a crossover study involving prophylactic treatment of 6 severely affected HAE patients who received study drug every three days.
Regulation (affected) of HAE associated with hereditary angioedema
10) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.74 Pain Relevance 0
Thus, despite the unavoidable limitation of our study being uncontrolled, the comparison with these historical data for untreated or placebo-treated attacks nevertheless indicate the efficacy of C1-INH at the recommended dose of 20 U/kg in the treatment of laryngeal edema attacks.
Regulation (efficacy) of C1-INH associated with laryngeal edema
11) Confidence 0.27 Published 2010 Journal J Clin Immunol Section Body Doc Link PMC2970824 Disease Relevance 0.26 Pain Relevance 0
The effect of renal failure on HAE and vice versa is also unknown.
Regulation (effect) of HAE associated with renal failure
12) Confidence 0.16 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2577685 Disease Relevance 1.28 Pain Relevance 0.05
HAE affects 1:10,000 to 1:50,000 people and is caused by mutations in the C1 inhibitor gene[5].
Regulation (affects) of HAE associated with hereditary angioedema
13) Confidence 0.15 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 1.45 Pain Relevance 0
Oikine et al have reported that twice-daily administration of premixed insulin resulted in improved glycemic control after morning and evening meals, but a change in overall A1C values was not observed [49].
Regulation (change) of A1C
14) Confidence 0.01 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.18 Pain Relevance 0.03

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