INT94029

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 58
Total Number 61
Disease Relevance 24.20
Pain Relevance 42.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
ACC 5
forebrain 3
pyramidal neurons 3
spines 2
neurons 2
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 1448 100.00 Very High Very High Very High
long-term potentiation 1179 100.00 Very High Very High Very High
Inflammation 213 100.00 Very High Very High Very High
Dorsal horn 111 100.00 Very High Very High Very High
nociceptor 35 100.00 Very High Very High Very High
depression 113 99.96 Very High Very High Very High
Morphine 680 99.84 Very High Very High Very High
Anterior cingulate cortex 1224 99.68 Very High Very High Very High
Pyramidal cell 128 99.52 Very High Very High Very High
Central grey 154 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 113 99.96 Very High Very High Very High
INFLAMMATION 203 99.72 Very High Very High Very High
Injury 176 99.56 Very High Very High Very High
Urological Neuroanatomy 158 99.36 Very High Very High Very High
Convulsion 21 99.16 Very High Very High Very High
Targeted Disruption 405 99.14 Very High Very High Very High
Pain 590 99.12 Very High Very High Very High
Morphine Dependence 27 99.12 Very High Very High Very High
Death 43 98.80 Very High Very High Very High
Inflammatory Pain 81 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.
Positive_regulation (Upregulation) of NR2B in forebrain associated with inflammation
1) Confidence 0.70 Published 2005 Journal J. Neurosci. Section Title Doc Link 16319310 Disease Relevance 0.61 Pain Relevance 0.86
Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation.
Positive_regulation (upregulation) of NR2B in ACC associated with inflammation and anterior cingulate cortex
2) Confidence 0.70 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.67 Pain Relevance 0.62
However, it is not known whether inflammation leads to the upregulation of NR2B receptors in these regions.
Spec (whether) Positive_regulation (upregulation) of NR2B associated with inflammation
3) Confidence 0.70 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.60 Pain Relevance 0.55
In addition, postsynaptic upregulation of NMDA receptor NR2B subunits in the ACC pyramidal neurons has also been reported after tissue inflammation [17].
Positive_regulation (upregulation) of NR2B in pyramidal neurons associated with inflammation, pyramidal cell, nmda receptor and anterior cingulate cortex
4) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.81 Pain Relevance 0.66
For example, peripheral inflammation at one hindpaw in adult mice increased the expression level of NR2B proteins in the ACC [17].
Positive_regulation (increased) of NR2B associated with inflammation and anterior cingulate cortex
5) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.69 Pain Relevance 0.56
Since the function of NR2B was upregulated in the ACC of morphine treated mice, we investigated whether LTP was also enhanced.
Positive_regulation (upregulated) of NR2B associated with long-term potentiation, anterior cingulate cortex and morphine
6) Confidence 0.68 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0 Pain Relevance 1.06
Upregulation of NMDA receptor NR2B subunit functions in chronic pain
Positive_regulation (Upregulation) of NR2B associated with lasting pain and nmda receptor
7) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.93 Pain Relevance 0.84
In a recent study we found that after persistent inflammation (the Complete Freund's Adjuvant (CFA) animal model for chronic inflammation), the expression of NMDA NR2B receptors in the ACC was increased over a long-period of time, thereby increasing the NR2B component in NMDA receptor mediated EPSCs [17] (see Figure 3A, B).
Positive_regulation (increasing) of NR2B associated with inflammation, nmda receptor and anterior cingulate cortex
8) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 1.08 Pain Relevance 1.15
M) blocked 34.1 ± 5.4% (n = 7) of the total train-induced NMDA current in saline treated mice (Figure 4C and 4D), while a significant increase in the NR2B component was again seen in morphine treated mice (53.7 ± 4.5%, n = 7, P < 0.05) (Figure 4C and 4D).
Positive_regulation (increase) of NR2B associated with morphine
9) Confidence 0.59 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0 Pain Relevance 1.10
Under these conditions, the NR2B subunit protein is up-regulated in the limbic forebrain of morphine-conditioned mice.
Positive_regulation (up-regulated) of NR2B in forebrain associated with morphine
10) Confidence 0.56 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11233291 Disease Relevance 0.22 Pain Relevance 1.15
In the present study, the increase in the protein level of NR2B was much higher than NR2A in the rdta mice.
Positive_regulation (increase) of NR2B
11) Confidence 0.55 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.08 Pain Relevance 0.30
The mechanism by which the NR2A/B ratio changes is determined by the length of dark exposure: short periods shift the ratio through increasing NR2B levels, whereas with longer periods NR2B protein levels return to normal and NR2A levels decrease (Chen & Bear 2007).
Positive_regulation (increasing) of NR2B
12) Confidence 0.55 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.06 Pain Relevance 0.21
Collectively, these data are consistent with an NMDAR hyperfunction upon knockout of native PrPC, which is not caused by an augmentation of NR2B-containing receptors.
Positive_regulation (augmentation) of NR2B-containing associated with targeted disruption
13) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.16 Pain Relevance 0.05
Previous in situ hybridization experiments have suggested that NR2A and NR2B but not NR1 mRNA may be upregulated in both young and adult PrP-null mice (Maglio et al., 2004, 2006), which is not supported by our semiquantitative PCR experiments.
Positive_regulation (upregulated) of NR2B
14) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.05 Pain Relevance 0.06
For example, enriched animals display better leaning, enhanced hippocampal LTP, increased NMDA receptor NR2B subunit mediated currents in the forebrain [9,10].
Positive_regulation (increased) of NR2B in forebrain associated with nmda receptor and long-term potentiation
15) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.30 Pain Relevance 0.87
Taken together, these results suggest that chronic morphine treatment increases both synaptic and extrasynaptic NR2B NMDA receptor activity.


Positive_regulation (increases) of NR2B associated with nmda receptor and morphine
16) Confidence 0.49 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0 Pain Relevance 1.12
Our results are consistent with an important role of NR2B subunits in triggering SD in the entorhinal cortex.
Positive_regulation (role) of NR2B in cortex associated with depression
17) Confidence 0.49 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 15201313 Disease Relevance 0.83 Pain Relevance 0.50
Subsequently, NMDA receptors including NR2A and NR2B can be activated, resulting in the elevation of intracellular Ca2+ in postsynaptic cells [4].
Positive_regulation (activated) of NR2B associated with nmda receptor
18) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.19 Pain Relevance 0.68
For example, presynaptic glutamate release is enhanced while postsynaptic NMDA NR2B subunit is upregulated in the ACC pyramidal neurons after peripheral inflammation [9,10].
Positive_regulation (upregulated) of NR2B in pyramidal neurons associated with glutamate, inflammation, pyramidal cell and anterior cingulate cortex
19) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.63 Pain Relevance 1.02
For example, presynaptic glutamate release is enhanced while postsynaptic NMDA NR2B subunit is upregulated in the ACC pyramidal neurons after peripheral inflammation [9,10].
Positive_regulation (upregulated) of NR2B in pyramidal neurons associated with glutamate, inflammation, pyramidal cell and anterior cingulate cortex
20) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.43 Pain Relevance 0.64

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