INT94042

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 13.52
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100A8) extracellular region (S100A8) plasma membrane (S100A8)
cytoskeleton (S100A8) cytoplasm (S100A8)
Anatomy Link Frequency
MIA PaCa-2 6
plaque 4
epithelial cell 2
PANC-1 2
S100A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 17 100.00 Very High Very High Very High
Chronic pancreatitis 17 99.64 Very High Very High Very High
peptic ulcer disease 2 99.42 Very High Very High Very High
Angina 5 98.60 Very High Very High Very High
Inflammation 33 79.44 Quite High
Arthritis 3 79.00 Quite High
Pain 4 75.08 Quite High
cytokine 3 70.32 Quite High
abdominal pain 7 69.08 Quite High
anakinra 4 66.00 Quite High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 16 100.00 Very High Very High Very High
Atherosclerotic Plaque 3 100.00 Very High Very High Very High
Pancreatic Cancer 56 99.96 Very High Very High Very High
Cancer 55 99.92 Very High Very High Very High
Prostate Cancer 46 99.84 Very High Very High Very High
Pancreatitis 38 99.84 Very High Very High Very High
Disease 58 99.42 Very High Very High Very High
Myocardial Infarction 4 99.40 Very High Very High Very High
Ulcers 2 99.26 Very High Very High Very High
Duodenitis 2 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced expression of S100A8/A9 in atherosclerotic plaque of patients with unstable angina pectoris (UAP) has been demonstrated, but its profile in acute myocardial infarction (AMI) has not been clarified.
Positive_regulation (Enhanced) of Gene_expression (expression) of S100A8 in plaque associated with atherosclerotic plaque, angina and myocardial infarction
1) Confidence 0.67 Published 2010 Journal Circ. J. Section Abstract Doc Link 20190427 Disease Relevance 0.47 Pain Relevance 0.20
Reverse transcription-PCR analysis confirmed p8 mRNA overexpression (tumor/nontumor ratio >2) in 75% (3 of 4) of PCs. p8 was overexpressed also in human pancreatic cancer cell lines (MIA PaCa-2 and PANC-1).
Positive_regulation (overexpression) of Gene_expression (overexpression) of p8 in MIA PaCa-2 associated with cancer and pancreatic cancer
2) Confidence 0.49 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.97 Pain Relevance 0.09
Reverse transcription-PCR analysis confirmed p8 mRNA overexpression (tumor/nontumor ratio >2) in 75% (3 of 4) of PCs. p8 was overexpressed also in human pancreatic cancer cell lines (MIA PaCa-2 and PANC-1).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of p8 in MIA PaCa-2 associated with cancer and pancreatic cancer
3) Confidence 0.49 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.95 Pain Relevance 0.09
We investigated p8 expression in 72 human pancreatic tissues, including 38 pancreatic cancers (PCs), by immunohistochemistry. p8 was overexpressed (positive cells >25% in 1,000 cells) in 71% (27 of 38) of PCs, but in only 17% (3 of 18) of chronic pancreatitis cases.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of p8 associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.49 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.94 Pain Relevance 0.10
The p8 overexpression rate in PC was significantly higher than that in other conditions (P < 0.05).
Positive_regulation (overexpression) of Gene_expression (overexpression) of p8
5) Confidence 0.49 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.97 Pain Relevance 0.10
The p8 gene is a recently identified gene with mitogenic activity. p8 expression is induced in acute pancreatitis, pancreatic development, and regeneration.
Positive_regulation (induced) of Gene_expression (expression) of p8 associated with pancreatitis
6) Confidence 0.49 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.64 Pain Relevance 0.07
OBJECTIVE: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA.
Spec (whether) Positive_regulation (upregulated) of Spec (whether) Gene_expression (expression) of S100A8 in plaques
7) Confidence 0.49 Published 2008 Journal Heart Section Body Doc Link 18308864 Disease Relevance 0.19 Pain Relevance 0
Moreover, in AfricanAmerican patients undergoing endoscopy: (1) HP infection was inversely related to the number of years the patients have been living in the USA; (2) HP infection rates were higher in patients diagnosed with duodenitis and peptic ulcer disease versus other disorders; (3) expression of the CagA gene was not associated with any specific gastroduodenal disorder; and (4) there was little allelic heterogeneity with respect to VacA and IceA subtypes.
Neg (not) Positive_regulation (associated) of Gene_expression (expression) of CagA associated with peptic ulcer disease, duodenitis, disease and infection
8) Confidence 0.49 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12141819 Disease Relevance 1.13 Pain Relevance 0.17
Mutations in the cationic trypsinogen gene, pancreatic secretory trypsin inhibitor, and the cystic fibrosis conductance regulator gene do not account for the chronic pancreatitis noted in most patients with idiopathic chronic pancreatitis.
Neg (not) Positive_regulation (account) of Gene_expression (Mutations) of cystic fibrosis associated with fibrosis, cystic fibrosis and chronic pancreatitis
9) Confidence 0.49 Published 2004 Journal Rev Esp Enferm Dig Section Abstract Doc Link 15506908 Disease Relevance 0.82 Pain Relevance 0.63
G542X is a Class I mutation that results in the complete failure to synthesize functional cystic fibrosis transmembrane conductance regulator (CFTR) and is usually associated with pancreatic insufficiency.
Positive_regulation (conductance) of Neg (failure) Gene_expression (synthesize) of cystic fibrosis associated with fibrosis, exocrine pancreatic insufficiency and cystic fibrosis
10) Confidence 0.49 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936924 Disease Relevance 1.39 Pain Relevance 0.35
Enhanced expression of the S100A8/A9 complex in acute myocardial infarction patients.
Positive_regulation (Enhanced) of Gene_expression (expression) of S100A8 associated with myocardial infarction
11) Confidence 0.49 Published 2010 Journal Circ. J. Section Title Doc Link 20190427 Disease Relevance 0.37 Pain Relevance 0.18
This apparent discrepancy might be explained by a compensatory increase in S100A8 and S100A9 expression by a non-epithelial cell type, as suggested by Tieu et al. [36], but this awaits further clarification.
Positive_regulation (increase) of Gene_expression (expression) of S100A8 in epithelial cell
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.77 Pain Relevance 0.07
Reverse transcription-PCR analysis confirmed p8 mRNA overexpression (tumor/nontumor ratio >2) in 75% (3 of 4) of PCs. p8 was overexpressed also in human pancreatic cancer cell lines (MIA PaCa-2 and PANC-1).
Positive_regulation (overexpressed) of in PANC-1 Gene_expression (overexpressed) of p8 in MIA PaCa-2 associated with cancer and pancreatic cancer
13) Confidence 0.17 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.95 Pain Relevance 0.09
Reverse transcription-PCR analysis confirmed p8 mRNA overexpression (tumor/nontumor ratio >2) in 75% (3 of 4) of PCs. p8 was overexpressed also in human pancreatic cancer cell lines (MIA PaCa-2 and PANC-1).
Positive_regulation (overexpression) of in PANC-1 Gene_expression (overexpression) of p8 in MIA PaCa-2 associated with cancer and pancreatic cancer
14) Confidence 0.17 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.97 Pain Relevance 0.09
Trp-p8 is mainly detected in the prostate and shows an overexpression in PCa of early stages and low grades [34, 51].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p8 associated with prostate cancer
15) Confidence 0.09 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.21 Pain Relevance 0
Other potential markers of SoJIA have also been reported; serum levels of the myeloid-related proteins 8 and 14 (MRP-8 and MRP-14) were significantly higher in SoJIA patients than in healthy or other disease controls [23].
Positive_regulation (higher) of Gene_expression (levels) of MRP-8 associated with disease
16) Confidence 0.06 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948378 Disease Relevance 0.79 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox