INT94045

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 3.56
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Cacna1a) plasma membrane (Cacna1a) nucleus (Cacna1a)
neurological system process (Cacna1a) transmembrane transport (Cacna1a) cytoplasm (Cacna1a)
Cacna1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 30 99.34 Very High Very High Very High
Cluster headache 7 99.28 Very High Very High Very High
Calcium channel 4 96.52 Very High Very High Very High
Neurotransmitter 1 90.92 High High
corticosteroid 105 85.44 High High
headache 1 58.64 Quite High
tolerance 9 47.80 Quite Low
Glutamate 6 15.12 Low Low
spastic colon 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 3 99.78 Very High Very High Very High
Headache 15 99.34 Very High Very High Very High
Cluster Headache 7 99.28 Very High Very High Very High
Migraine With Aura 15 98.36 Very High Very High Very High
Disease 6 75.00 Quite High
Insulin Resistance 6 73.72 Quite High
Neurological Disease 1 72.56 Quite High
Primary Headache Disorders 1 59.00 Quite High
Exsanguination 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to investigate the involvement of the CACNA1A and ATP1A2 gene in a population-based sample of sporadic hemiplegic migraine (SHM).
Spec (investigate) Regulation (involvement) of CACNA1A associated with migraine
1) Confidence 0.42 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18513263 Disease Relevance 0.59 Pain Relevance 0.59
Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura.
Regulation (Involvement) of CACNA1A associated with epilepsy and migraine
2) Confidence 0.25 Published 2001 Journal Neurology Section Title Doc Link 11320173 Disease Relevance 0.20 Pain Relevance 0.29
Affected sib-pair analysis in families with migraine with and without aura indicates involvement of the CACNA1A gene in these more frequent types of migraine.
Regulation (involvement) of CACNA1A gene associated with epilepsy and migraine
3) Confidence 0.25 Published 2001 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 11236374 Disease Relevance 0.86 Pain Relevance 0.87
We conclude that an importance of the CACNA1A gene in sporadic CH is unlikely.
Regulation (importance) of CACNA1A associated with cluster headache
4) Confidence 0.24 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11843866 Disease Relevance 0.89 Pain Relevance 0.78
Further studies with additional families will be necessary to reveal the importance of both CACNA1A and ATP1A2 genes on the pathogeneses of FHM in Brazil and to test the third gene (SCN1A) in these FHM families.
Regulation (importance) of CACNA1A associated with migraine
5) Confidence 0.20 Published 2006 Journal Arq Neuropsiquiatr Section Abstract Doc Link 17119788 Disease Relevance 0.74 Pain Relevance 0.67
Class 1 and Class 4A were the simplest regulation patterns apparent amongst all the classes.
Regulation (regulation) of Class
6) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.14 Pain Relevance 0.07
Class 1 and Class 4A were the simplest regulation patterns apparent amongst all the classes.
Regulation (regulation) of Class
7) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.14 Pain Relevance 0.07
Acute dosing of MPL causes down-regulation for this class of genes which can be captured by Model F where DR(N) inhibits the production rate (ksyn, Enzm) of the mRNA.
Regulation (regulation) of class
8) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox